Angiogenesis in Cancer Therapy
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell and Gene Therapy".
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 3224
Special Issue Editors
Interests: angiogenesis; endothelial cells; integrins; extracellular matrix; cell adhesion; tumor progression; vascular biology; signal transduction in endothelium and platelets; oxidative stress and vasculature; toll-like receptors in angiogenesis
Interests: angiogenesis; tumor angiogenesis; innate immunity of vasculature; toll-like receptors in angiogenesis; endothelial cells; extracellular matrix; endothelial mechanosensing
Special Issue Information
Dear Colleagues,
As human longevity continues to increase and a significant portion (>25%) of the world population is already aged over 50, neoplasm incident rates are expected to climb and pose a significant public health and economic burden. While it is already well established that tumors must acquire pro-angiogenic properties in order to facilitate growth and metastasize, exciting new research is linking interplay between tumor growth, vascular biology, and immunology. It is becoming evident that not only is the immune system capable of either suppressing or promoting tumor growth, but it is also capable of modulating the endothelium in order to achieve these results. Indeed, both anti-angiogenics and immunotherapies have had variable successes in clinical trials. As a result, studies that seek to elucidate interactions between the immune system and the endothelium in the context of the tumor microenvironment are of considerable interest to the future of disease treatment. However, current underpinnings of myeloid cell–endothelial cell interactions that promote disease remain poorly defined.
This Special Issue aims to summarize the current knowledge of the role of the immune system in modulating angiogenesis in tumor microenvironments and the wider implications that this may have in future therapies.
We look forward to your correspondence.
Prof. Tatiana V. Byzova
Dr. Michael G. McCoy
Guest Editor
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