Exclusive Review Papers in Cellular Metabolism: From Basic to Clinical Metabolic Research

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 2102

Special Issue Editor


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Guest Editor
Department of Physiology, Medical University of Bialystok, Mickiewicza 2C Street, 15-222 Bialystok, Poland
Interests: obesity; mesenchymal stem cells; insulin resistance; diabetes mellitus; cardiovascular diseases; adipocytes; skeletal muscle; metabolic syndrome; lipid metabolism; fatty acid handling proteins, cellular metabolism
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Special Issue Information

Dear Colleagues,

Cellular metabolism plays a crucial role in all living organisms, and it is based on the interplay of many genes, proteins, and metabolites. Evidently numerous human diseases stem from perturbations of homeostasis that lead to severe tissue dysfunction.

This Special Issue aims to provide a comprehensive overview of cell metabolism underlying physiological homeostasis and disturbances thereof in pathological conditions in different cells, organs, and systems. Authors are invited to submit review articles, meta-analyses and systematic reviews with new insights into cellular and molecular homeostatic processes. These include, but are not limited to, mesenchymal stem cell biology, adipose tissue biology, cardiovascular biology, pancreatic beta cell function, mitochondria and other metabolic organelles biology, glucose metabolism, lipid metabolism, and exercise metabolism. Submissions related to both existing and future therapies for metabolic disease (e.g., type 1 and 2 diabetes, cardiovascular disease, obesity, lipid disorders) are also welcome.

Dr. Agnieszka Mikłosz
Guest Editor

Manuscript Submission Information

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Keywords

  • cell metabolism
  • mesenchymal stem cell biology
  • adipose tissue biology
  • cardiovascular biology
  • pancreatic beta cell function
  • glucose metabolism
  • lipid metabolism
  • exercise metabolism
  • obesity
  • type 2 diabetes mellitus
  • metabolic syndrome

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Published Papers (1 paper)

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Review

30 pages, 2334 KiB  
Review
Receptors and Signaling Pathways Controlling Beta-Cell Function and Survival as Targets for Anti-Diabetic Therapeutic Strategies
by Stéphane Dalle and Amar Abderrahmani
Cells 2024, 13(15), 1244; https://doi.org/10.3390/cells13151244 - 24 Jul 2024
Viewed by 1412
Abstract
Preserving the function and survival of pancreatic beta-cells, in order to achieve long-term glycemic control and prevent complications, is an essential feature for an innovative drug to have clinical value in the treatment of diabetes. Innovative research is developing therapeutic strategies to prevent [...] Read more.
Preserving the function and survival of pancreatic beta-cells, in order to achieve long-term glycemic control and prevent complications, is an essential feature for an innovative drug to have clinical value in the treatment of diabetes. Innovative research is developing therapeutic strategies to prevent pathogenic mechanisms and protect beta-cells from the deleterious effects of inflammation and/or chronic hyperglycemia over time. A better understanding of receptors and signaling pathways, and of how they interact with each other in beta-cells, remains crucial and is a prerequisite for any strategy to develop therapeutic tools aimed at modulating beta-cell function and/or mass. Here, we present a comprehensive review of our knowledge on membrane and intracellular receptors and signaling pathways as targets of interest to protect beta-cells from dysfunction and apoptotic death, which opens or could open the way to the development of innovative therapies for diabetes. Full article
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