Extracellular Vesicles as Diagnostic and Therapeutic Tools in Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: 28 April 2025 | Viewed by 34
Special Issue Editor
Interests: EVs in cancer drug resistance and therapy escape; mechanisms underlying EV uptake and cargo utilization
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The concept of extracellular vesicles representing a mediator of intercellular communication has sparked new interest regarding their roles both in physiological processes and in disease processes. EVs are tiny membrane-bound vesicles, with a diameter in the range of 50–1000 nm, that can carry cargo including RNAs—both mRNAs and small RNAs—proteins, glycoproteins, and lipids. They are produced ubiquitously by most cells and secreted into the extracellular space; from here, they can make their way into the bodily fluids and blood stream, thus accessing both neighbouring and distant cells. Research has increased over the last two decades and has provided evidence of their involvement in numerous facets of cancer, including initiation, progression including invasion and metastasis, and response to treatment. They have also been shown to comprise a means of communication between tumour cells and the other cellular and acellular components of the tumour microenvironment. The possibility that these facets of EVs could be harnessed in cancer diagnosis and therapy is fuelling further research in this area. For this Special Issue, we are inviting original papers and review articles on the following topics: I) EV cargo as biomarkers indicating the initiation, progression, or therapeutic behaviours of cancer; II) EV mediation in crosstalk with non-malignant cells; III) the role of EVs in the progression of cancer, including metastasis, and IV) EVs as therapeutic tools.
Dr. Priya Samuel
Guest Editor
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Keywords
- extracellular vesicles
- tumour microenvironment
- cancer
- biomarkers
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