Role of Cell Organelles in Normal Aging, Senescence, and Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 15 March 2025 | Viewed by 184
Special Issue Editors
Interests: cancer stem cells; cancer metabolism; tumour recurrence and metastasis; drug resistance; clinical trials
Special Issues, Collections and Topics in MDPI journals
2. Center for Translational Imaging, Georgetown University Medical Center, Washington, DC 20057, USA
3. Department of Radiology, Georgetown University Medical Center, Washington, DC 20057, USA
Interests: cancer biology; drug resistance; GI cancers; imaging sciences; magnetic resonance imaging (MRI); neurologic; brain; CNS cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organismal and cellular aging is a chronological process that may be the result of accumulated damage, including REDOX-related modifications of DNA, RNA and lipids, as well as protein aggregation, resulting in cellular dysfunction. However, the root cause of aging remains a debated topic and is an area of great interest to the research community. The number of aging-associated diseases is high, and these include cancer, diabetes and heart disease, as well as dementia and other neuro-degenerative disorders.
One of the hallmarks of aging is the appearance of senescent cells. These cells undergo cell cycle arrest mostly due to the up-regulation of cyclin-dependent kinase inhibitors (p16, p19-ARF and p21-WAF), and increase their biosynthetic production of inflammatory mediators that are part of the SASP (senescence-associated secretory phenotype), such as IL-1-beta, IL-6, and IL-8, etc.
Senescent cells also show characteristic morphological and functional organellar changes in their nuclei, mitochondria, lysosomes and endocytic capacity.
This Special Issue will explore the fundamental role of cell organelles in senescence, the aging process and senescence escape in cancer cells. Comprehensive reviews and original articles are both welcome. There will also be a focus on the mitochondrial–lysosomal axis of aging.
Dr. Michael Lisanti
Dr. Christopher Albanese
Guest Editors
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Keywords
- aging
- accumulated damage
- ROS-induced damage
- protein aggregation
- senescence
- cancer
- senescence escape
- cell organelles
- mitochondria
- lysosomes
- SASP
- inflammation
- IL1-beta/IL-6/IL-8
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