Metabolic Hallmarks in Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 165
Special Issue Editors
Interests: cancer stem cells; cancer metabolism; tumour recurrence and metastasis; drug resistance; clinical trials
Special Issues, Collections and Topics in MDPI journals
Interests: metabolic interactions in the tumor microenvironment; mechanisms through which oxidative stress induces cancer cells to proliferate and resistance to cell death; the role of autophagy in cancer cell aggressiveness
Interests: cancer stem cells; cancer metabolism; tumor recurrence and metastasis; drug resistance; drug discovery
Special Issue Information
Dear Colleagues,
Cancer is a complex disease that disrupts the delicate balance of cellular processes, with metabolic reprogramming being a central hallmark. This reprogramming is a result of the intricate interplay between cellular and molecular mechanisms that enable cancer cells to adapt, survive, and proliferate in a nutrient-limited and hypoxic tumor microenvironment. The cellular and molecular aspects of cancer metabolism involve a shift in energy production pathways, alterations in biosynthetic processes, and the exploitation of metabolic intermediates for the synthesis of macromolecules essential for tumor growth.
This Special Issue will explore the fundamental metabolic adaptations that cancer cells undergo, such as the Warburg effect, the reverse Warburg effect, glutamine addiction, and the pentose phosphate pathway's role in nucleotide synthesis. By focusing on these cellular and molecular aspects, we aim to provide insights into the metabolic pathways that are uniquely altered in cancer and how these changes contribute to the disease's progression, offering potential targets for novel therapeutic interventions.
Both comprehensive reviews and original articles are welcome.
Dr. Michael Lisanti
Dr. Ubaldo Martinez-Outshoorn
Dr. Marta Mauro-Lizcano
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- metabolic reprogramming
- metabolic adaptation
- cancer energy metabolism
- glycolysis
- the Warburg effect
- the reverse Warburg effect
- glutamine addiction
- the pentose phosphate pathway
- cellular and molecular mechanisms
- tumor microenvironment
- novel therapeutic interventions
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