Lipids and Lipidomics in Neurodegenerative Diseases

Dear Colleagues,

Neurodegenerative diseases represent one of the major health emergencies and one of the leading causes of death worldwide. Millions of individuals are impacted by neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, or amyotrophic lateral sclerosis. Multiple pathological processes contribute to the progression of these diseases, including neuroinflammation, oxidative stress, endoplasmic reticulum stress, and neuronal death, although the precise causes and chronology of these events have not yet been established. It is nevertheless accepted that the disruption of lipid homeostasis contributes greatly to the pathogenesis of neurodegenerative diseases, particularly due to the high lipid content of brain tissue. Lipids are active biomolecules that play key roles in various cerebral cellular processes, such as neuronal membrane dynamics, interactions with membrane proteins, and the consequences for their functionality, signaling and gene regulation, and endo/exocytosis. Understanding their role in the development of neurodegenerative diseases is therefore essential and must be based on relevant fundamental research. In this context, lipidomics represents a major research tool for understanding the mechanisms, discovering prognostic or diagnostic biomarkers, and identifying therapeutic targets, given the wide diversity of lipid molecular species involved.

To date, the treatment and cure of neurodegenerative disease remain a significant challenge because of an incomplete understanding of the events that lead to the selective neurodegeneration of brains. The aim of this Special Issue is to provide an overview of the current knowledge of molecular and cellular lipid pathways involved in neurodegenerative diseases, lipid alterations associated with neurodegenerative diseases, the interest of lipids in the treatment of neurodegenerative diseases, and lipidomics in the prevention, diagnosis, and treatment of neurodegenerative diseases.

This Special Issue welcomes submissions of original studies and reviews.

Dr. Nathalie Bernoud-Hubac
Dr. Catherine Malaplate
Guest Editors

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• lipids
• lipidomics
• neurodegenerative disease diagnosis, prevention, or treatment
• cellular and molecular mechanisms