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Cells
Special Issues
Hypoxia and Cancer: New Aspects 2.0
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Hypoxia and Cancer: New Aspects 2.0

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1432

Special Issue Editors

Prof. Dr. Francesco Pezzella

E-Mail Website
Guest Editor
Nuffield Division of Clinical Laboratory Science, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Interests: relationship between cancer cells and blood vessels
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Mahvash Tavassoli

E-Mail Website
Guest Editor
King’s College, Guy’s Hospital, London, UK
Interests: apoptin; apoptosis; prognostic biomarkers; combination therapy; head and neck cancer; tumour hypoxia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Interest in the effect of hypoxia, both on cancer and non-neoplastic cells, has continued to grow in recent years, as evidenced by the large number of publications on the topic according to PubMed. Another, small, testimonial of this interest is our first Special Issue on Cancer and Hypoxia. In this first collection, papers looking at basic physiological mechanisms, effects on pathways in cancer cells, and the role played in resistance to treatment and effects on the immune system were published, showing how broad this field is. The latter is one of the areas of investigation that has been recently expanding as the interaction between levels of cellular oxygenation and the immune system is becoming increasingly important in cancer. The oxygen level of cancer cells is also being recognized as affecting the behavior of the tumor-associated stroma. The study of hypoxia in both cancer cells and associated stroma is another emerging area where epigenetics is becoming an important component. Alongside this, the study of hypoxia in physiology, such as adaptation to high altitudes, is providing a wealth of data useful for cancer research.

All this considered, we have decided it would be a good idea to launch a second edition of the Special Issue on Cancer and Hypoxia and invite the scientific community to send us more data on hypoxia and cancer, from basic science to translational application. However, we also invite work on the physiology of hypoxia in non-neoplastic conditions, as dialogue between the cancer and non-cancer communities would certainly benefit both.

Thanks to all of you!

Prof. Dr. Francesco Pezzella
Prof. Dr. Mahvash Tavassoli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypoxia
  • cancer
  • physiology

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Published Papers (1 paper)

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Review

14 pages, 1036 KiB  
Review
Affinity of PET-MRI Tracers for Hypoxic Cells in Breast Cancer: A Systematic Review
by Ioana-Claudia Costin and Loredana G. Marcu
Cells 2024, 13(12), 1048; https://doi.org/10.3390/cells13121048 - 17 Jun 2024
Viewed by 881
Abstract
Tumour hypoxia is a known microenvironmental culprit for treatment resistance, tumour recurrence and promotion of metastatic spread. Despite the long-known existence of this factor within the tumour milieu, hypoxia is still one of the greatest challenges in cancer management. The transition from invasive [...] Read more.
Tumour hypoxia is a known microenvironmental culprit for treatment resistance, tumour recurrence and promotion of metastatic spread. Despite the long-known existence of this factor within the tumour milieu, hypoxia is still one of the greatest challenges in cancer management. The transition from invasive and less reliable detection methods to more accurate and non-invasive ways to identify and quantify hypoxia was a long process that eventually led to the promising results showed by functional imaging techniques. Hybrid imaging, such as PET-CT, has the great advantage of combining the structural or anatomical image (offered by CT) with the functional or metabolic one (offered by PET). However, in the context of hypoxia, it is only the PET image taken after appropriate radiotracer administration that would supply hypoxia-specific information. To overcome this limitation, the development of the latest hybrid imaging systems, such as PET-MRI, enables a synergistic approach towards hypoxia imaging, with both methods having the potential to provide functional information on the tumour microenvironment. This study is designed as a systematic review of the literature on the newest developments of PET-MRI for the imaging of hypoxic cells in breast cancer. The analysis includes the affinity of various PET-MRI tracers for hypoxia in this patient group as well as the correlations between PET-specific and MRI-specific parameters, to offer a broader view on the potential for the widespread clinical implementation of this hybrid imaging technique. Full article
(This article belongs to the Special Issue Hypoxia and Cancer: New Aspects 2.0)
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