Behind and beyond Neuroinflammation: State of the Art and New Perspectives
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 2083
Special Issue Editors
Interests: neuroinflammation; astrocyte-microglia interplay; neurodegeneration; amyloid proteins; cell membrane
Special Issues, Collections and Topics in MDPI journals
Interests: blood–brain barrier; vitamin D; cadmium toxicity; cannabidiol; neuroprotection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroinflammation is currently considered a hallmark of most neurological disorders, consisting of the collective dynamic response of glial cells to impaired nervous tissue homeostasis. The reactivities of astrocytes and
microglia are characterized by a wide spectrum of phenotypes that, in chronic diseases, may shift from neuroprotective to neurotoxic. It is known that the reactivity of glial cells is modulated by environmental conditions, including both the chemical and physical properties of the extracellular matrix, and
intense signaling reverberating among different cell types. According to an emerging idea, all cells in the nervous system are, indeed, connected by an intricate network of mutual influences and interdependencies, where intercellular interactions represent links and nodes. A deeper knowledge of the properties of this network, including the mechanisms that promote collective responses to different challenges, in both normal and pathological conditions, could help to understand some of the most controversial features of neuroinflammation.
This Special Issue fits this two-fold perspective; it is dedicated to research that can increase the current knowledge of cell interactions in neuroinflammation and their role in normal conditions. In addition, studies regarding how these interactions are affected by, or may affect, the extracellular matrix will also be considered for publication. This could inspire the concept of the nervous tissue as a microsystem, whose properties are affected by lifespan adaptations to a changing microenvironment.
Dr. Daniele Nosi
Dr. Jacopo Junio Valerio Branca
Guest Editors
Manuscript Submission Information
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Keywords
- astrocytes
- microglia
- neurons
- intercellular interactions
- neurodegeneration
- neuroprotection
- extracellular matrix
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Related Special Issue
- Frontiers in Neuroinflammation in Cells (15 articles)
