Friends or Foes: Innate Immune Cells and Soluble Mediators in Mucosal Inflammation
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 8801
Special Issue Editors
Interests: asthma; autoimmunity; BTK; epigenetics; immune signaling; lymphocytes
Special Issues, Collections and Topics in MDPI journals
2. Department of Cell Biology, Erasmus MC Rotterdam PO Box 2040, NL 3000 CA Rotterdam, The Netherlands
Interests: lymphocytes,; neutrophils; chemokines; leukocyte migration; immunological memory; auto-inflammation & autoimmunity
Special Issue Information
Dear Colleagues,
Mucosal barrier tissues—such as the lungs and intestines—are the first contact sites for potentially harmful substances present in the external environment. These complex cellular landscapes are tasked with maintaining tissue homeostasis by tolerating harmless (self)antigens while eliminating pathogenic threats.
Optimal host protection at mucosal surfaces initially depends on dynamic cooperation between epithelial cells and dedicated innate immune cells. Epithelial cells form the first line of defense by providing a physical and biochemical barrier. Resident innate immune cells, including dendritic cells and macrophages, act as sentinels by sensing pathogen- or danger-associated signals. Following activation, they secrete an array of soluble factors, including cytokines, chemokines and growth factors, that act in concert with epithelium-derived mediators to activate innate lymphoid cells (ILCs) and recruit neutrophils and monocytes into the tissue. Instructed by the local cytokine and chemokine milieu, innate immune cells not only activate the adaptive arm to provide a specific long-lasting response, but also directly contribute to pathogen elimination and are involved in regaining tissue homeostasis after pathogen clearance.
Correct fine-tuning of mucosal immune responses is vital for health, as intrinsic defects in innate immune mechanisms feed into susceptibility to infections or malignancies, whereas excessive activation may cause chronic inflammation and tissue damage.
With this Special Issue, we wish to provide new insights into the role of innate immune cells and soluble mediators such as cytokines and chemokines in mucosal immunology in health and disease. We invite you to contribute original research articles, reviews or shorter perspective articles related to this topic.
Dr. Rudi Hendriks
Dr. Mieke Metzemaekers
Dr. Lisette Krabbendam
Guest Editors
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Keywords
- innate immunity
- mucosal immunology
- homeostasis
- inflammation
- cytokines
- chemokines
- innate leukocytes
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