Mechanism of Nuclear Hormone Receptors in Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: closed (14 July 2022) | Viewed by 7045
Special Issue Editors
Interests: hormone-dependent cancers; steroid hormone receptors; estrogen; androgen
Special Issues, Collections and Topics in MDPI journals
Interests: estrogen receptor; breast cancer; osteoporosis; vitamin K
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The relationship between hormones and cancer has a long history. It can be traced back to the 19th century when Dr. Beatson treated a breast cancer patient by ovariectomy in 1896. In 1941, Dr. Huggins performed orchidectomy and administered estrogen to a prostate cancer patient, which lead to his receipt of the Nobel Prize in 1966. In 1971, tamoxifen came into clinical use as an endocrine therapy for breast cancer. Interestingly, the clinical use of tamoxifen preceded the molecular cloning of the estrogen receptor in 1986. Now, we understand the importance of the estrogen receptors and the androgen receptor as transcription factors in the pathogenesis of breast cancer and prostate cancer. Investigations of novel mechanisms of these receptors, such as nongenomic actions or post-transcriptional modifications, are ongoing.
The estrogen receptors and the androgen receptor belong to the nuclear receptor superfamily. Several members of this superfamily are classified as steroid or other hormone receptor subfamily. In relation with malignancies, their ligands including glucocorticoids and retinoic acid are clinically used for lymphoma and leukemia. In addition, it has been suggested that nuclear receptors without corresponding steroid ligands or orphan nuclear receptors whose endogenous ligands have not been discovered are involved in the mechanism of cancer development.
This Special Issue aims to summarize the current knowledge of the nuclear hormone receptors in relationship with cancer biology. We invite experts in this field to submit original research papers or reviews on the various nuclear receptors in human cancers. A wide range of studies from basic to clinical studies are welcome.
Prof. Dr. Satoshi Inoue
Dr. Kotaro Azuma
Guest Editors
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Keywords
- hormone
- nuclear receptor
- genetics
- transcription
- RNA regulation
- epigenetics
- protein modification
- cancer
- metabolomics
- breast
- prostate
- uterus
- ovary
- testis
- endocrine-related cancer
- hormone therapy
- refractory cancer
- CRPC
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