Recent Advances of Endothelial Progenitor Cells in Vascular Endothelial Function and Tissue Repair

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".

Deadline for manuscript submissions: closed (15 July 2024) | Viewed by 2030

Special Issue Editors


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Guest Editor
1. Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, National and Kapodistrian University of Athens, 106 75 Athens, Greece
2. Cardiac Surgery ICU, Onassis Cardiac Surgery Center, 176 74 Athens, Greece
Interests: critical care medicine; CPET applications; cardiopulmonary rehabilitation; rehabilitation in critical ill patients; microcirculation; exercise training; near-infrared spectroscopy; lung sonography; CHF; pulmonary arterial hypertension; left ventricle assist device; ECMO

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Guest Editor
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, 1st Critical Care Medicine Department, Evangelismos Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece
Interests: heart failure; endothelial progenitor cells; endothelium; myocardial infarction; revascularization; cardiopulmonary resuscitation; myocarditis; cardiopulmonary exercise testing; exercise training; rehabilitation
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Special Issue Information

Dear Colleagues,

This Special Issue entitled “Recent Advances of Endothelial Progenitor Cells in Vascular Endothelial Function and Tissue Repair” focuses on the most updated knowledge in the field of Endothelial Progenitor Cells and, most specifically, on the:

  1. Review of the existing methods or new proposals for identification and quantification;
  2. Potential pathophysiological mechanisms of mobilization, differentiation, vascular protection and tissue repair in a wide spectrum of diseases and clinical syndromes;
  3. Clinical translation of the existing findings of original research;
  4. Future perspectives and potential clinical indications of Endothelial Progenitor Cells.

We are pleased to invite authors to submit their original research, recommendation articles, and/or reviews covering all aspects of Endothelial Progenitor Cells. Participation in this Special Issue through the submission of a manuscript could be an excellent opportunity for senior researchers to enrich their CVs, for doctoral or post-doctoral trainees to gain experience in writing reviews and for institutions to present their original research in a high-quality journal.

Dr. Stavros Dimopoulos
Dr. Christos Kourek
Guest Editors

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Keywords

  • endothelial progenitor cells
  • endothelium
  • vascular endothelial function
  • tissue repair
  • regeneration
  • vascular homeostasis
  • infusion
  • mobilization
  • differentiation
  • translational research

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Published Papers (1 paper)

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Review

16 pages, 860 KiB  
Review
Cellular and Noncellular Approaches for Repairing the Damaged Blood–CNS–Barrier in Amyotrophic Lateral Sclerosis
by Larai Manora, Cesario V. Borlongan and Svitlana Garbuzova-Davis
Cells 2024, 13(5), 435; https://doi.org/10.3390/cells13050435 - 29 Feb 2024
Viewed by 1643
Abstract
Numerous reports have demonstrated the breakdown of the blood–CNS barrier (B-CNS-B) in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Re-establishing barrier integrity in the CNS is critical to prevent further motor neuron degeneration from harmful components in systemic circulation. Potential therapeutic strategies [...] Read more.
Numerous reports have demonstrated the breakdown of the blood–CNS barrier (B-CNS-B) in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Re-establishing barrier integrity in the CNS is critical to prevent further motor neuron degeneration from harmful components in systemic circulation. Potential therapeutic strategies for repairing the B-CNS-B may be achieved by the replacement of damaged endothelial cells (ECs) via stem cell administration or enhancement of endogenous EC survival through the delivery of bioactive particles secreted by stem cells. These cellular and noncellular approaches are thoroughly discussed in the present review. Specific attention is given to certain stem cell types for EC replacement. Also, various nanoparticles secreted by stem cells as well as other biomolecules are elucidated as promising agents for endogenous EC repair. Although the noted in vitro and in vivo studies show the feasibility of the proposed therapeutic approaches to the repair of the B-CNS-B in ALS, further investigation is needed prior to clinical transition. Full article
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