Biology of Retinal Ganglion Cells
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 3029
Special Issue Editor
Special Issue Information
Dear Colleagues,
In neuroscience, retinal ganglion cells (RGCs) have played a major role in the establishment of the fundamental principles governing patterned neuronal network formation and maturation in the central nervous system (CNS). In addition, the use of retinal ganglion cells has been instrumental in the elucidation of the mechanisms responsible for neuronal cell death and for the inhibition of axonal regeneration in the injured CNS of mammals. The extraordinary importance of retinal ganglion cells in neuroscience is in great part due to their accessibility in the eye, allowing for relatively simple assessment of experimental treatments with pharmacological compounds, viral vectors, blocking antibodies, etc. In addition, the degeneration of retinal ganglion cells and their axon in the optic nerve is involved in the visual function deficits associated with prevalent and incurable diseases such as glaucoma or multiple sclerosis. For these reasons, RGCs have received particular attention from basic scientists and clinicians. Tremendous progress has been accomplished in recent years with the identification of RGC subpopulations, several of which are anatomically well-characterized, and their role in visual and non-visual functions, in addition to their differential vulnerability to injury.
In this Special Issue of Cells, I invite you to contribute with original research articles, reviews, or shorter perspective articles in regard to all aspects related to the theme of the “Biology of Retinal Ganglion Cells”. Expert articles describing mechanistic, functional, cellular, biochemical, or general aspects of retinal ganglion cells are highly welcome. Relevant topics include but are not limited to
- RGC function
- Axonal regeneration
- Neuronal survival
- Gene therapy
- Neuroinflammation
- Neuronal development
- Retinogenesis
- Retinotectal projection
- The optic nerve
- Glaucoma
- Multiple sclerosis
- Gene therapy
- Cell therapy
Dr. Vincent Pernet
Guest Editor
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Keywords
- retinal ganglion cells
- vision
- optic nerve
- development
- retinal diseases
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