Cellular and Molecular Dysregulations of Solid Tumors
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1786
Special Issue Editor
Interests: molecular oncology; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer continues to take a toll on global public health systems, accounting for an estimated 8.7 million deaths annually. In 2015, 17.5 million incident cases were diagnosed worldwide, and this is projected to spiral to 22.2 million by 2030.
Despite tremendous progress in reducing mortality rates from cancer and transformative shifts in therapeutic paradigms over the past few years, investigation of the molecular and cellular aspects of solid tumor remains an urgent priority.
Solid tumors commonly arise from genetic mutations in driver oncogenes and tumor suppressor genes that have profound consequences on cell differentiation, proliferation, survival, and genomic stability. During cancer progression, tumor cells alter normal developmental processes to orchestrate a supportive but overtly immunosuppressive tumor microenvironment (TME) comprised of immune cells, fibroblasts, and endothelial cells, often embedded within a robust extracellular matrix (ECM). Characterizing the complex composition of cellular and molecular aspects of solid tumors is fundamental for understanding tumor initiation, progression and metastasis. In this Special Issue, we invite investigators to contribute original research or review articles that highlight recent important advances in cellular and molecular dysregulations of solid tumors. Potential topics include but are not limited to the following:
- Genomic and proteomic characteristics of solid tumors
- Tumor microenvironment and its role in tumor development, growth, and metastasis
- Cancer stem cells and their roles in tumor development, drug resistance, and metastasis
- Dysregulation of signaling pathways and their role in promoting cancer and drug resistance
- Novel mechanisms underlying tumor development
Dr. Raheleh Roudi
Guest Editor
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Keywords
- solid tumors
- signaling pathways
- genetic dysregulations
- cellular abnormalities
- cancer treatment
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