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Advances in Chemosensors Technologies for Monitoring and Diagnostics

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A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "(Bio)chemical Sensing".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 17394

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Special Issue Editors

Dr. Anirban Paul

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Guest Editor

Department of Bioengineering, University of Texas at Dallas, 800 W Campbell Rd., Richardson, TX 75080, USA
Interests: electrochemical sensor; microelectrode; analytical electrochemistry; RTIL

Prof. Dr. Giuseppe Maruccio

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Guest Editor

Omnics Research Group, Department of Mathematics and Physics "Ennio De Giorgi", University of Salento, Institute of Nanotechnology CNR-Nanotec, INFN Sezione di Lecce, Via per Monteroni, 73100 Lecce, Italy
Interests: lab on chip; organ on chip; biosensors; diagnostics; drug screening
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Special Issue Information

Dear Colleagues,

The advancement of chemosensor technology is considered to be one of the emerging fields in science due to its wide application in healthcare, industry, environmental monitoring, and many more. Chemosensor is a platform which provides meaningful signal output due to selective chemical interactions. Chemosensors have a direct application in day-to-day human activity, from monitoring to diagnosis. Chemosensors generally consist of unique transducers which enable them to convert chemical signal to meaningful signal output viz. optical, electrical, electrochemical etc. Along with its unique feasibility, the technology can also be employed to miniaturization along with point of care setting. There is a huge array of chemosensor technologies that have emerged based on various modes of operation, which include colorimetry, field effect transistor, -omics, -onics, electrochemical etc. The applications of these technologies are also huge. Monitoring and diagnostic application is one of the prime applications of such chemosensors. The use of chemosensors in environmental monitoring provides a useful solution to tackle pollution. Chemosensors are a very popular choice for indoor industry set up, to avoid any possible occupational hazard. One of the important applications in such a regime is the detection of harmful chemicals, gases and VOCs related to indoor industry setup. Air quality monitoring is also one of the most important applications that chemosensors are able to perform. The use of sensors for monitoring soil health is also an emerging topic, and chemosensory response helps one to understand soil behaviour. As well as this, soil, food, and pharma industries are also equally utilizing the potential of chemo sensing technology for monitoring food samples, as well as pharma samples respectively.

Disease diagnosis is currently considered one of the most important aspects of healthcare management. It is an ancient practice, and it has helped to provide crucial information for clinical decisions that influence outcomes for serious acute illnesses. Moreover, mankind has truly understood the importance of diagnosis/testing in the middle of this global pandemic when testing has been proven to be the major key factor to solve this puzzle. There are several technologies that have been introduced decades ago to analyze human health, and a huge amount of infrastructure and expenditure has been adopted by several governments retrospectively. Current advancements in diagnostic technology have enabled easy-to-use point of care biomedical devices. Wearables, Internet of Things (IoT) platforms constitute an emerging field of chemosensory application.

This Special Issue aims to serve larger perspectives for the advancement of chemosensor application in monitoring and diagnosis. Recent advancements include newer materials and newer technologies for chemosensor application. Monitoring and diagnosis application includes industrial application, environmental management, healthcare monitoring, disease diagnosis wearables, etc.

Dr. Anirban Paul
Dr. Giuseppe Maruccio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

chemosensor
environmental monitor
health care management
industrial application
disease diagnosis

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Published Papers (6 papers)

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Research

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18 pages, 6582 KiB

Open AccessArticle

Application of Molecularly Imprinted Microelectrode as a Promising Point-of-Care Biosensor for Alanine Aminotransferase Enzyme

by Mostafa Ahmed Samy, Muhammed Abdel-Hamied Abdel-Tawab, Nour. T. Abdel-Ghani and Rasha M. El Nashar

Chemosensors 2023, 11(5), 262; https://doi.org/10.3390/chemosensors11050262 - 27 Apr 2023

Cited by 3 | Viewed by 1978

Abstract

Alanine amino transaminase (ALT) is an enzyme that can be used as a biomarker for liver injury and other diseases. In this work, we report the development of the first microelectrode based on a molecularly imprinted pyruvate oxidase enzyme to be applied as an electrochemical biosensor for ALT detection. The biosensor is based on pyruvate oxidase enzyme (POx), imprinted using 4-aminophenol (functional monomer-on-platinum microelectrode modified (PME)) with platinum nanoparticles and 4-aminoantypirine (4-AAP)/sodium pyruvate as an electrochemical indicator. The operational conditions of the biosensor were optimized and characterized morphologically using scanning electron microscopy (SEM) and electrochemically using electrochemical impedance spectroscopy (EIS). The biosensor was found to have a fast response towards ALT within a linear range of 25–700 U/L and a limit of detection of 2.97 U/L. The biosensor did not exhibit cross-reactivity towards other tested enzymes, including nicotinamide adenine dinucleotide (Beta-NAD), catalase (CAT), glutathione peroxidase (GPx), and L-glutathione reduced (GSH) enzymes. The biosensor was efficiently applied for the assay of ALT in plasma samples; with recovery values ranging from 99.80–103.82% and RSD of values 0.27–2.01% and these results were found to be comparable to those of the reference diagnostic kits, without any need for complicated procedures or protein extraction. In addition to being highly sensitive, low cost, and portable, the use of microelectrodes allows the application of the proposed sensor for point-of-care diagnostics of liver function and online monitoring of ALT levels in hospitalized patients without the need for withdrawing samples, which indicates the promising applicability of the presented ALT sensor for point-of-care diagnostics. Full article

(This article belongs to the Special Issue Advances in Chemosensors Technologies for Monitoring and Diagnostics)

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13 pages, 5477 KiB

Open AccessArticle

Room-Temperature NO₂ Gas Sensors Based on Granulated Carbon Nanofiber Material

by Alexander G. Bannov, Nikita I. Lapekin, Pavel B. Kurmashov, Arina V. Ukhina and Anton Manakhov

Chemosensors 2022, 10(12), 525; https://doi.org/10.3390/chemosensors10120525 - 10 Dec 2022

Cited by 6 | Viewed by 2232

Abstract

Room-temperature gas sensors based on granulated carbon nanofiber material were investigated for the detection of NO₂. The granulated material consisting of intertwined carbon nanofibers was synthesized by the decomposition of CH₄ over the Ni/Al₂O₃ catalyst in a vibro-fluidized bed reactor. Carbon material was investigated using transmission electron microscopy, Raman spectroscopy, low-temperature nitrogen adsorption, and X-ray photoelectron spectroscopy. Investigation of the gas sensors towards NO₂ at room temperature (25 ± 2 °C) was carried out in a dynamic flow-through setup in the range from 1 to 500 ppm. A comparison of the sensitivity gas sensor to NH₃ and CH₄ was also given. The sensor based on non-treated carbon nanofiber material showed the response ΔR/R₀ of 5.1 % to 10 ppm of NO₂. It was found that the sensor response to NO₂ decreased when increasing the relative humidity. The effect of the relative humidity was more pronounced for low concentrations of nitrogen dioxide and decreases with a further increase in them. Full article

(This article belongs to the Special Issue Advances in Chemosensors Technologies for Monitoring and Diagnostics)

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27 pages, 10139 KiB

Open AccessArticle

Development of a Portable and Modular Gas Generator: Application to Formaldehyde Analysis

by Anaïs Becker, Nathaly Lohmann, Christophe A. Serra and Stéphane Le Calvé

Chemosensors 2022, 10(4), 131; https://doi.org/10.3390/chemosensors10040131 - 31 Mar 2022

Cited by 3 | Viewed by 3574

Abstract

This work aims at developing and validating under laboratory-controlled conditions a gas mixture generation device designed for easy on-site or laboratory calibration of analytical instruments dedicated to air monitoring, such as analysers or sensors. This portable device, which has been validated for formaldehyde, is compact and is based on the diffusion of liquid formaldehyde through a short microporous interface with an air stream to reach non-Henry equilibrium gas–liquid dynamics. The geometry of the temperature-controlled assembly has been optimised to allow easy change of the aqueous solution, keeping the microporous tube straight. The formaldehyde generator has been coupled to an on-line formaldehyde analyser to monitor the gas concentration generated as a function of the liquid formaldehyde concentration, the temperature, the air gas flow rate, and the microporous tube length. Our experimental results show that the generated gaseous formaldehyde concentration increase linearly between 10 and 1740 µg m⁻³ with that of the aqueous solution ranging between 0 and 200 mg L⁻¹ for all the gas flow rates studied, namely 25, 50 and 100 mL min⁻¹. The generated gas phase concentration also increases with increasing temperature according to Henry’s law and with increasing the gas–liquid contact time either by reducing the gas flow rate from 100 to 25 mL min⁻¹ or increasing the microporous tube length from 3.5 to 14 cm. Finally, the performances of this modular formaldehyde generator are compared and discussed with those reported in the scientific literature or commercialised by manufacturers. The technique developed here is the only one allowing to operate with a low flow rate such as 25 to 100 mL min⁻¹ while generating a wide range of concentrations (10–1000 µg m⁻³) with very good accuracy. Full article

(This article belongs to the Special Issue Advances in Chemosensors Technologies for Monitoring and Diagnostics)

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13 pages, 3350 KiB

Open AccessArticle

A Novel Truncated DNAzyme Modified Paper Analytical Device for Point-of-Care Test of Copper Ions in Natural Waters

by Jiayi Wu, Ming Wang, Huanhuan Hong, Jianyuan Lin, Ning Gan and Wenchao Bi

Chemosensors 2022, 10(2), 72; https://doi.org/10.3390/chemosensors10020072 - 10 Feb 2022

Cited by 4 | Viewed by 3262 | Correction

Abstract

On-site determination of trace copper ions in natural waters is of great significance to environmental monitoring, and how to develop accurate and specific point-of-care test methods is one critical issue. In the study, a paper-based analytical device (PAD) being modified with a new truncated DNAzyme (CLICK-T, which was derived from a reported DNAzyme-CLICK-17) was developed for Cu ions detection. The detection mechanism was based on Cu(II)-catalyzed azide-alkyne cycloaddition (Cu(II)AAC) reaction. It can directly conduct on-site analysis of Cu(II) ions based on fluorescent signals detected using a mobile phone. In the assay, the CLICK-T was firstly modified on the PADs. Then, water samples containing Cu ions mixed with 3-azido-7-hydroxycoumarin and 3-butyn-1-ol were instantly dripped on PADs and incubated for 20 min. Finally, the PADs were excited at 365 nm and emitted fluorescence which could be analyzed on site using smart phones. The Cu(II) concentration could be quantified through RGB analysis with the aid of iPhone APP software. The limit of detection is 0.1 µM by the naked eye due to the fact that CLICK-T exhibited a good catalytic effect on Cu(II)AAC. The Cu(II) concentration could also be directly detected without using reductant, such as ascorbic acid, which is prone to be oxidized in air. This simplifies the PDA detection process improves its efficiency. The PAD is convenient for the on-site analysis of Cu ions in natural waters. Full article

(This article belongs to the Special Issue Advances in Chemosensors Technologies for Monitoring and Diagnostics)

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Review

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18 pages, 1596 KiB

Open AccessReview

Development of Electrochemical Sensors/Biosensors to Detect Natural and Synthetic Compounds Related to Agroalimentary, Environmental and Health Systems in Argentina. A Review of the Last Decade

by Adrian M. Granero, Héctor Fernández, María A. Zon, Sebastián N. Robledo, Gastón D. Pierini, Aylen Di Tocco, Roodney A. Carrillo Palomino, Sabrina Maccio, Walter I. Riberi and Fernando J. Arévalo

Chemosensors 2021, 9(11), 294; https://doi.org/10.3390/chemosensors9110294 - 20 Oct 2021

Cited by 7 | Viewed by 2729

Abstract

Electrochemical sensors and biosensors are analytical tools, which are in continuous development with the aim of generating new analytical devices which are more reliable, cheaper, faster, sensitive, selective, and robust than others. In matrices related to agroalimentary, environmental, or health systems, natural or synthetic compounds occur which fulfil specific roles; some of them (such as mycotoxins or herbicides) may possess harmful properties, and others (such as antioxidants) beneficial ones. This imposes a challenge to develop new tools and analytical methodologies for their detection and quantification. This review summarises different aspects related to the development of electrochemical sensors and biosensors carried out in Argentina in the last ten years for application in agroalimentary, environmental, and health fields. The discussion focuses on the construction and development of electroanalytical methodologies for the determination of mycotoxins, herbicides, and natural and synthetic antioxidants. Studies based on the use of different electrode materials modified with micro/nanostructures, functional groups, and biomolecules, complemented by the use of chemometric tools, are explored. Results of the latest reports from research groups in Argentina are presented. The main goals are highlighted. Full article

(This article belongs to the Special Issue Advances in Chemosensors Technologies for Monitoring and Diagnostics)

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