Advances in Molecular Biology Methods in Hepatology Research
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 2599
Special Issue Editors
Interests: molecular biology; liver fibrosis; drug discovery and development; advanced in vitro models
Interests: liver fibrosis; liver cell subpopulations; organoids; animal models; TGF-β; PDGF; metals; mass spectrometry; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent advances in molecular biology methods have profound implications for deciphering the complexities of hepatology research, specifically in understanding liver function, disease development and novel therapies. The integration of genomic technologies such as Next-Generation Sequencing (NGS), single-cell sequencing, CRISPR-Cas9 and epigenetic studies allow for a more comprehensive analysis of the liver's genomic landscape. Similarly, advancements in single-cell proteomic techniques, including sensitive mass spectrometry and high-throughput proteomics, have made it possible to identify and quantify liver proteins at the cellular level. These technologies enable scientists understand the molecular pathways involved in liver injury, fibrosis, and regeneration. In addition to advances in genomic techniques, the development of advanced hepatic in vivo models and liver tissue engineering, utilizing technologies such as CRISPR-Cas9, places a clear emphasis on creating humanized organoid models. These technologies, such as hepatic organoids, are scalable for high-throughput screening and can replicate complex cellular interactions, providing further insights into the mechanisms underlying liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD), hepatitis, and liver fibrosis. By creating patient-derived organoids, researchers can personalize disease models and thus uncover individualized disease mechanisms and precision therapeutics. Overall, these advancements in molecular biology have propelled hepatology research to the next level, offering additional opportunities for efficient diagnosis, treatment, and prevention strategies for hepatic diseases.
Dr. Dileep G. Nair
Prof. Dr. Ralf Weiskirchen
Guest Editors
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Keywords
- hepatic diseases
- molecular biology methods
- single-cell genomics
- single-cell proteomics
- hepatic organoids
- biomarkers
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