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Molecular Linkage between Immune System Disorders and Cardiovascular Diseases

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 3015

Special Issue Editor


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Guest Editor
1. Interdisciplinary Center for Clinical Research (IZKF), 52056 Aachen, Germany
2. Institute for Molecular Cardiovascular Research (IMCAR), 52056 Aachen, Germany
3. Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), 52056 Aachen, Germany
4. Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität (LMU) München, 80337 Munich, Germany
Interests: cardiovascular disease; atherosclerosis; chemokines; lipids; inflammation
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Special Issue Information

Dear Colleagues,

The immune system is a complex network of cells, tissues and organs that helps defend our bodies against infections. The immune system is composed of two major compartments: the innate and adaptive immune system, which work in synergy to ensure proper immunity.

However, this immune system can malfunction in various manners; it may be weakened, or acquired immune deficiency might occur. Both lead to immune system disorders that leave us vulnerable to infections. On the other hand, the immune system can also overreact, causing an allergic reaction or autoimmune disease, among other issues.

Since the immune system plays a key and driving role in the development of cardiovascular diseases, several of these immune system disorders have already been shown to contribute to the development of various cardiovascular diseases, e.g., atherosclerosis and heart failure. However, many of these interactions and their underlying mechanisms remain elusive.

This Special Issue will collect manuscripts that provide novel insights into the ways in which immune system disorders contribute to cardiovascular diseases.

Dr. Emiel P.C. van der Vorst
Guest Editor

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Published Papers (1 paper)

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36 pages, 1372 KiB  
Review
Molecular Linkage between Immune System Disorders and Atherosclerosis
by Katarzyna Napiórkowska-Baran, Oskar Schmidt, Bartłomiej Szymczak, Jakub Lubański, Agata Doligalska and Zbigniew Bartuzi
Curr. Issues Mol. Biol. 2023, 45(11), 8780-8815; https://doi.org/10.3390/cimb45110552 - 1 Nov 2023
Cited by 4 | Viewed by 2661
Abstract
A strong relationship exists between immune dysfunction and cardiovascular disease. Immune dysregulation can promote the development of cardiovascular diseases as well as exacerbate their course. The disorders may occur due to the presence of primary immune defects (currently known as inborn errors of [...] Read more.
A strong relationship exists between immune dysfunction and cardiovascular disease. Immune dysregulation can promote the development of cardiovascular diseases as well as exacerbate their course. The disorders may occur due to the presence of primary immune defects (currently known as inborn errors of immunity) and the more common secondary immune deficiencies. Secondary immune deficiencies can be caused by certain chronic conditions (such as diabetes, chronic kidney disease, obesity, autoimmune diseases, or cancer), nutritional deficiencies (including both lack of nutrients and bioactive non-nutrient compounds), and medical treatments and addictive substances. This article unravels the molecular linkage between the aforementioned immune system disorders and atherosclerosis. Full article
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