Molecular Insights into Skeletal Muscle Homeostasis and Metabolism
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 1878
Special Issue Editors
2. Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: skeletal muscle; myogenesis; regeneration; cell culture; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Interests: neuromuscular disorders; muscle regeneration; myokines; skeletal muscle; muscle biology; muscle damage; muscle proteins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Homeostasis is the ability of muscular tissue to maintain a stable and constant internal environment and is essential for its proper functioning. This process plays a crucial role in health and requires maintaining a dynamic balance between muscle growth, repairing/regeneration as a response to injury stimuli, and tissue breakdown. Maintaining the cytoplasmic calcium homeostasis in skeletal muscle, for example, is very important for intracellular signaling activity and metabolism.
Metabolism plays a crucial role in maintaining a good and correct functioning of the skeletal muscle. It refers to the chemical processes occurring in cells to convert nutrients into energy and other essential molecules. The energy demands of skeletal muscle are high as it is the responsibility of physical movement, posture, regulation of body energy, and protein metabolism. Exercise and physical activity may have a significant impact on skeletal muscle metabolism, promoting energy expenditure and metabolic adaptations. More of this, maintaining a normal muscle mass helps in therapy involving pathological states of other organs, such as various forms of cancer with muscle cachexia, some neurodegenerative diseases, and others. The cross-talking between skeletal muscle and other tissues and organs involves the releasing of myokines which have anti-inflammatory, metabolic, and regenerative effects.
In pathological conditions, the homeostasis and metabolism of skeletal muscle are severely affected, and we believe that the papers in this Special Issue, addressing specific aspects of these processes, will help researchers to gather a better understanding of underlying mechanisms and signaling pathways, to highlight more appropriate therapeutic approaches to improve muscle physiology to counteract various myopathology and more.
Potential topics include, but are not limited to:
- Niche satellite cells and cells communication in muscle homeostasis and metabolism dysregulations;
- Myofiber regeneration/repair in different pathological conditions;
- Muscle wasting disorders (myopathies, sarcopenia, cachexia, and others);
- Skeletal muscle inflammatory response;
- Exercise in skeletal muscle mass maintenance, role of myokines, and other aspects;
- Cytoplasmic calcium homeostasis dysregulation, mitochondrion response, and endoplasmic reticulum stress.
We would also like to thank Dr. Gisela Gaina for her contribution and support for this special issue.
Dr. Laura Cristina Ceafalan
Dr. Emilia Manole
Guest Editors
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Keywords
- skeletal muscle
- muscle metabolism
- rhabdomyolysis
- storage diseases
- neuromuscular weakness
- mitochondrial myopathies
- myofiber regeneration/repair
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