Bioadhesion on Laser Functionalized Surfaces

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: 25 July 2025 | Viewed by 985

Special Issue Editors


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Guest Editor
Department of Mechanical Engineering, School of Engineering, The University of Birmingham, Birmingham B15 2TT, UK
Interests: laser surface functionalization; surface texturing; superhydrophobic surfaces; anti-biofouling; microfluidics and heat transfer; ultrafast lasers; laser micromachining; surface science and laser–material interactions

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Guest Editor
Department of Mechanical Engineering, University of Birmingham, Edgbaston B15 2TT, UK
Interests: laser micro-processing; laser surface texturing; laser pattterning; laser polishing; laser based powder bed fusion

Special Issue Information

Dear Colleagues,

Bioadhesion denotes the intrinsic capacity of biological entities, including cells, proteins, or organisms, to adhere to various surfaces. The strategic implementation of surface texturing can exercise profound influence over the adhesion characteristics of these biological entities to a given substrate. Understanding bioadhesion is of paramount significance, serving as a unifying nexus for interdisciplinary collaboration among researchers in the domains of biology, materials science, medicine, and engineering. This collective understanding facilitates the judicious design and manufacturing of highly efficient medical devices and marine equipment. Laser processing technology has emerged as a powerful tool for the fabrication of micro and nano topographies on metals, ceramics and polymers. Laser processing techniques, such as laser direct writing, direct laser interference patterning, and two-photon polymerization, are not only used to create micro and nanoscale features but also to modify the surface properties of the substrates. Pulsed lasers can selectively modify the surface properties of materials to make them biocompatible. This is critical when developing medical devices, implants, or drug delivery systems that need to interact with biological tissues without causing adverse reactions.

This Special Issue will provide an academic and scholarly platform for the dissemination of the latest technical accomplishments and for the elucidation of pivotal concerns and complexities poised to shape the trajectory of the field's future development.

The research topics within this Special Issue will include, but are not limited to, the following:

  • Laser textured surfaces for anti-fouling applications.
  • Protein adsorption on laser nanotextured surfaces.
  • Cell and bacterial attachment on laser-induced periodic surface structures (LIPSS).
  • Dynamic bioadhesion on laser micro/nano textures.
  • Biocompatibility and cytotoxicity of laser functionalised surfaces.
  • Modelling the role of surface topography and chemistry in bioadhesion.
  • Process chains involving laser surface modification for manufacturing medical devices.

Acknowledgments: 

Dr. Himani Sharma  <[email protected]>

Dr. Anvesh Gaddam
Dr. Pavel Penchev
Guest Editors

Manuscript Submission Information

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Keywords

  • anti-biofouling
  • biocompatibility
  • cell attachment
  • femtosecond laser
  • LIPSS
  • nanosecond laser
  • picosecond laser
  • protein adhesion
  • surface texturing
  • superhydrophilic
  • superhydrophobic.

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Published Papers (1 paper)

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Research

15 pages, 5737 KiB  
Article
Guidance of Osteoblast Migration Using Femtosecond Laser-Induced Hierarchical Structures
by Johannes Heitz, Simon Glachs, Lukas Wagner, Christoph Wolf, Cristina Plamadeala, Martina Muck, Karoline Seibert, Christian Maier, Romy Marek, Agnes Weth and Werner Baumgartner
Coatings 2025, 15(2), 127; https://doi.org/10.3390/coatings15020127 - 23 Jan 2025
Viewed by 628
Abstract
The adhesion and alignment of osteoblasts and fibroblasts on titanium alloy (Ti-6Al-4V) surfaces can be adjusted over a wide range by femtosecond laser treatment and anodization. The great differences in cell behavior between different experimental conditions raised further questions about the role of [...] Read more.
The adhesion and alignment of osteoblasts and fibroblasts on titanium alloy (Ti-6Al-4V) surfaces can be adjusted over a wide range by femtosecond laser treatment and anodization. The great differences in cell behavior between different experimental conditions raised further questions about the role of cell migration, which will be addressed in this study. For that, Ti-6Al-4V surfaces were laser-structured to obtain a surface covered with ripples, i.e., laser-induced periodic surface structures (LIPSS), or micro-cones superimposed with ripples. Then, cells were seeded either directly onto the non-structured or laser-structured areas on the titanium alloy samples or beside such samples where they can reach the surface by cell migration. After two weeks in culture, the cell coverage of the samples was evaluated by scanning electron microscopy (SEM). The results showed that cells directly seeded onto the non-structured or laser-structured areas covered the surface nearly completely and eventually aligned along the ripple direction for the laser-structured areas. In contrast, for cell-seeding beside the samples, the laser-structured areas remain nearly cell-free while the non-structured areas were covered with cells in a similar non-oriented manner as for direct cell-seeding. These results on reduced osteoblast migration due to laser structuring are in line with the findings in animal experiments. There, the new bone formation of laser-processed samples was 26.1% ± 16.9% lower in comparison to untreated samples of the same type, which can be explained by hindered cell migration on the laser-processed areas of the screws. Full article
(This article belongs to the Special Issue Bioadhesion on Laser Functionalized Surfaces)
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