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Hydroxyapatite Base Nanocomposites (Volume II)
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Hydroxyapatite Base Nanocomposites (Volume II)

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Hybrid and Composite Crystalline Materials".

Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 33314

Special Issue Editors

Dr. Réka Barabás

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Guest Editor
Faculty of Chemistry and Chemical Engineering，Babeş-Bolyai University(UBB), Cluj Napoca, Romania
Interests: Hap composites, bioceramics, bio-nanomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Liliana Bizo

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Guest Editor
Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania
Interests: oxide materials, biomaterials, optoelectronic materials, characterization methods (X-ray powder diffraction-XRPD)
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Graziella-Liana Turdean

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Guest Editor
Faculty of Chemistry and Chemical Engineering, Department of Chemical Engineering, Babes-Bolyai University, Arany Janos Street, No. 11, 400028 Cluj-Napoca, Romania
Interests: nano/materials for electrodes; supramolecular and nanostructured redox bio/systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue engineering is a very important research field in terms of the development of new structural materials for implants. Hydroxyapatite-based nanocomposites are promising materials for tissue engineering applications. Hydroxyapatite (Hap), which has excellent biocompatibility, could be combined with materials with other favorable properties, such as enhanced mechanical properties, flexibility, adsorption capacity, or porosity.

The nanosized constituent materials of the composites have certain advantages. For example, the constituent materials interact at a molecular level, they can be used to build self-assembled structures, and the specific surfaces of the nanocomposites are higher, meaning the adsorption capacity is enhanced.

As future materials for next-generation implants, Hap-based nanocomposites have enhanced mechanical properties, such as higher load-bearing capacity and flexibility as compared to natural bones.

On the other hand, nanocomposites can be used as coating materials for implants, meaning their adsorption capacity and porosity are essential factors in the adsorption of active substances with anti-inflammatory effects or in terms of the porosity of new bone tissue.

As drug carriers, Hap-based nanocomposites facilitate the trapping of active substances. These special structures, which can be built using different crosslinking agents, could retain the active substances inside of the composites and help adsorb different materials on the nanocomposites’ surfaces.

We invite researchers to contribute to this Special Issue on "Hap-Based Nanocomposites", which is intended to serve as a multidisciplinary forum covering broad aspects of science, technology, and the applications of Hap-based nanocomposites.

The main topics are as follows:

  • Preparation and characterization of bio-nanocomposites;
  • Applications of Hap-based nanocomposites;
  • Special structures of nanocomposites as drug carriers;
  • Interdependence of the structures and properties of nanocomposites;
  • Adsorption and desorption kinetics of Hap-based nanocomposites.

Dr. Réka Barabás
Dr. Liliana Bizo
Prof. Dr. Graziella-Liana Turdean
Guest Editors

Manuscript Submission Information

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Related Special Issue

Published Papers (7 papers)

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Research

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15 pages, 3371 KiB  
Article
Preparation of Hydroxyapatite-Titanium Dioxide Composite from Eggshell by Hydrothermal Method: Characterization and Antibacterial Activity
by Atiek Rostika Noviyanti, Efa Nur Asyiah, Muhamad Diki Permana, Dina Dwiyanti, Suryana and Diana Rakhmawaty Eddy
Crystals 2022, 12(11), 1599; https://doi.org/10.3390/cryst12111599 - 10 Nov 2022
Cited by 11 | Viewed by 2994
Abstract
Hydroxyapatite (HA) has been widely used in biomedical applications. HA is prepared from natural sources of eggshell. The obtained HA is composited with TiO2 using the hydrothermal method at a temperature of 230 °C. The structure and morphology of HA-TiO2 composites [...] Read more.
Hydroxyapatite (HA) has been widely used in biomedical applications. HA is prepared from natural sources of eggshell. The obtained HA is composited with TiO2 using the hydrothermal method at a temperature of 230 °C. The structure and morphology of HA-TiO2 composites are characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and a scanning electron microscope (SEM). Meanwhile, its antibacterial activity was tested on Staphylococcus aureus and Escherichia coli bacteria. The formation of the HA-TiO2 composite is evidenced by typical peaks on the XRD pattern for HA and TiO2. The FTIR spectrum shows that no bond formed between TiO2 and HA which indicates the formation of composites. The smallest crystallite size and the highest specific surface area were obtained from the composite with the composition of HA-TiO2 30:70. In addition, the composition of the composite also shows the smallest particle size distribution. Therefore, the presence of TiO2 plays a significant role in determining the HA properties formed. Furthermore, the HA-TiO2 composite showed good antibacterial activity using disk diffusion and optical density (OD) methods. These results indicate that the synergistic combination of HA from eggshell with TiO2 has favorable properties for antibacterial activity. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites (Volume II))
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17 pages, 3448 KiB  
Article
Calcium Carbonate Originating from Snail Shells for Synthesis of Hydroxyapatite/L-Lysine Composite: Characterization and Application to the Electroanalysis of Toluidine Blue
by Jimmy Julio Kouanang Ngouoko, Kevin Yemele Tajeu, Cyrille Ghislain Fotsop, Arnaud Kamdem Tamo, Giscard Doungmo, Ranil Clément Tonleu Temgoua, Théophile Kamgaing and Ignas Kenfack Tonle
Crystals 2022, 12(9), 1189; https://doi.org/10.3390/cryst12091189 - 24 Aug 2022
Cited by 4 | Viewed by 3316
Abstract
Snail shells (Anadora Fulica) calcined at different temperatures were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermal analyses (TG-DTG), scanning electron microscopy (SEM) and N2 adsorption–desorption experiments (surface area measurements were found using the coupled BET/BJH method). [...] Read more.
Snail shells (Anadora Fulica) calcined at different temperatures were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermal analyses (TG-DTG), scanning electron microscopy (SEM) and N2 adsorption–desorption experiments (surface area measurements were found using the coupled BET/BJH method). The principal objective was to identify different forms of calcium carbonate and calcium hydroxide in snail shells as raw materials. The calcium hydroxide thus obtained was used in the synthesis of the hydroxyapatite/L-lysine (HA/Lys) composite. The composite used to chemically modify a glassy carbon electrode (GCE) was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). It appeared that the developed sensor Lys/HA/GCE facilitated electronic transfer compared to the pristine electrode. In a strongly acid medium, this surface protonated and therefore became positively charged, which allowed it to have a good affinity with [Fe(CN)6]3-. An application in toluidine blue (TB) electroanalysis in the phosphate buffer was carried out. Optimal sensor performances were obtained using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The performance of the sensor was determined in the concentration range 1 to 10 µM of TB, and the limit of detection (LOD) obtained by the S/N = 3 method was 2.78 × 10−7 M. The sensor was also used to detect the TB in spring water at 96.79% recovery. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites (Volume II))
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7 pages, 2771 KiB  
Communication
Incorporation of Iron(II) and (III) in Hydroxyapatite—A Theoretical Study
by Olga Nikolaevna Makshakova, Daria Vladimirovna Shurtakova, Alexey Vladimirovich Vakhin, Peter Olegovich Grishin and Marat Revgerovich Gafurov
Crystals 2021, 11(10), 1219; https://doi.org/10.3390/cryst11101219 - 9 Oct 2021
Cited by 15 | Viewed by 2902
Abstract
Hydroxyapatite (Ca10(PO4)6(OH)2, HAp) doped with various transition metals has generated great interest in view of its potential application in a wide variety of fields, including in catalysis as a support with a series of attractive [...] Read more.
Hydroxyapatite (Ca10(PO4)6(OH)2, HAp) doped with various transition metals has generated great interest in view of its potential application in a wide variety of fields, including in catalysis as a support with a series of attractive properties. Despite a large number of experimental works devoted to the synthesis and application of iron-substituted hydroxyapatites, problems concerning the location, introduced defects, and charge compensation schemes for Fe2+ and/or Fe3+ cations in the crystal structure of HAp remain unclear. This paper is devoted to the comprehensive analysis of iron (II) and (III) introduction into the HAp lattice by density functional theory (DFT) calculations. We show that the inclusion of Fe2+ in the Ca(1) and Ca(2) positions of HAp is energetically comparable. For the Fe3+, there is a clear preference to be included in the Ca(2) position. The inclusion of iron results in cell contraction, which is more pronounced in the case of Fe3+. In addition, Fe3+ may form a shorter linkage to oxygen atoms. The incorporation of both Fe2+ and Fe3+ leads to notable local reorganization in the HAp cell. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites (Volume II))
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17 pages, 5329 KiB  
Article
Hydroxyapatite and Silicon-Modified Hydroxyapatite as Drug Carriers for 4-Aminopyridine
by Laura Marincaș, Graziella Liana Turdean, Monica Toșa, Zsolt Kovács, Béla Kovács, Réka Barabás, Noémi-Izabella Farkas and Liliana Bizo
Crystals 2021, 11(9), 1124; https://doi.org/10.3390/cryst11091124 - 15 Sep 2021
Cited by 9 | Viewed by 3059
Abstract
Adsorption and desorption properties of nano-hydroxyapatite (HAP) and silicon-modified hydroxyapatite (Si–HAP) were investigated with 4-aminopyridine (fampridine-4AP). The novelty of this research is the investigation of the suitability of the previously mentioned carriers for drug-delivery of 4AP. UV-VIS spectrophotometric results showed that the presence [...] Read more.
Adsorption and desorption properties of nano-hydroxyapatite (HAP) and silicon-modified hydroxyapatite (Si–HAP) were investigated with 4-aminopyridine (fampridine-4AP). The novelty of this research is the investigation of the suitability of the previously mentioned carriers for drug-delivery of 4AP. UV-VIS spectrophotometric results showed that the presence of silicon in the carrier did not significantly affect its adsorption capacity. The success of the adsorption was confirmed by thermal analysis (TG/DTA), scanning electron microscopy (SEM)/energy dispersive X-ray (EDX), Fourier transform infrared (FTIR) spectroscopy, and X-ray powder diffraction (XRPD). Drug release experiments, performed in simulated body fluid (SBF), revealed a drug release from Si–HAP that was five times slower than HAP, explained by the good chemical bonding between the silanol groups of the carrier and the 4AP functional groups. The electrochemical measurements showed a value of the polarization resistance of the charge transfer (Rct) more than five times smaller in the case of Si–HAP coating loaded with 4AP, so the charge transfer process was hindered. The electrochemical impedance results revealed that electron transfer was inhibited in the presence of 4AP, in concordance with the previously mentioned strong bonds. The silicon substitution in HAP leads to good chemical bonding with the drug and a slow release, respectively. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites (Volume II))
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7 pages, 676 KiB  
Communication
Using DFT to Calculate the Parameters of the Crystal Field in Mn2+ Doped Hydroxyapatite Crystals
by Daria Vladimirovna Shurtakova, Peter Olegovich Grishin, Marat Revgerovich Gafurov and Georgy Vladimirovich Mamin
Crystals 2021, 11(9), 1050; https://doi.org/10.3390/cryst11091050 - 31 Aug 2021
Cited by 9 | Viewed by 3400
Abstract
Crystal field parameters for two nonequivalent positions Ca (I) and Ca (II) for hydroxyapatite (HAp) crystals from the density functional theory (DFT) are calculated. Calculations are compared with the experimental electron paramagnetic resonance (EPR) spectra (registered at two microwave frequencies) for the synthesized [...] Read more.
Crystal field parameters for two nonequivalent positions Ca (I) and Ca (II) for hydroxyapatite (HAp) crystals from the density functional theory (DFT) are calculated. Calculations are compared with the experimental electron paramagnetic resonance (EPR) spectra (registered at two microwave frequencies) for the synthesized Mn-HAp powders Ca9.995Mn0.005(PO4)6(OH)2. It is found that in the investigated species, the manganese is redistributed between both calcium sites with prevalence in Ca (I). Agreement between the calculated and experimental data proves that crystal field parameters in HAp can be calculated in the classical DFT model using the distributed electron density. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites (Volume II))
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14 pages, 3454 KiB  
Article
Photoluminescent Properties of Hydroxyapatite and Hydroxyapatite/Multi-Walled Carbon Nanotube Composites
by Edna X. Figueroa-Rosales, Javier Martínez-Juárez, Esmeralda García-Díaz, Daniel Hernández-Cruz, Sergio A. Sabinas-Hernández and Maria J. Robles-Águila
Crystals 2021, 11(7), 832; https://doi.org/10.3390/cryst11070832 - 17 Jul 2021
Cited by 24 | Viewed by 3972
Abstract
Hydroxyapatite (HAp) and hydroxyapatite/multi-walled carbon nanotube (MWCNT) composites were obtained by the co-precipitation method, followed by ultrasound-assisted and microwave radiation and thermal treatment at 250 °C. X-ray diffraction (XRD) confirmed the presence of a hexagonal phase in all the samples, while Fourier-transform infrared [...] Read more.
Hydroxyapatite (HAp) and hydroxyapatite/multi-walled carbon nanotube (MWCNT) composites were obtained by the co-precipitation method, followed by ultrasound-assisted and microwave radiation and thermal treatment at 250 °C. X-ray diffraction (XRD) confirmed the presence of a hexagonal phase in all the samples, while Fourier-transform infrared (FTIR) spectroscopy elucidated the interaction between HAp and MWCNTs. The photoluminescent technique revealed that HAp and the composite with non-functionalized MWCNTs present a blue luminescence, while the composite with functionalized MWCNTs, under UV-vis radiation shows an intense white emission. These findings allowed presentation of a proposal for the use of HAp and HAp with functionalized MWCNTs as potential materials for optoelectronic and medical applications. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites (Volume II))
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Review

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19 pages, 1732 KiB  
Review
Dental Applications of Systems Based on Hydroxyapatite Nanoparticles—An Evidence-Based Update
by Silvia Balhuc, Radu Campian, Anca Labunet, Marius Negucioiu, Smaranda Buduru and Andreea Kui
Crystals 2021, 11(6), 674; https://doi.org/10.3390/cryst11060674 - 11 Jun 2021
Cited by 56 | Viewed by 12070
Abstract
Hydroxyapatite is one of the most studied biomaterials in the medical and dental field, because of its biocompatibility; it is the main constituent of the mineral part of teeth and bones. In dental science, hydroxyapatite nanoparticles (HAnps) or nano-hydroxyapatite (nano-HA) have been studied, [...] Read more.
Hydroxyapatite is one of the most studied biomaterials in the medical and dental field, because of its biocompatibility; it is the main constituent of the mineral part of teeth and bones. In dental science, hydroxyapatite nanoparticles (HAnps) or nano-hydroxyapatite (nano-HA) have been studied, over the last decade, in terms of oral implantology and bone reconstruction, as well in restorative and preventive dentistry. Hydroxyapatite nanoparticles have significant remineralizing effects on initial enamel lesions, and they have also been used as an additive material in order to improve existing and widely used dental materials, mainly in preventive fields, but also in restorative and regenerative fields. This paper investigates the role of HAnps in dentistry, including recent advances in the field of its use, as well as their advantages of using it as a component in other dental materials, whether experimental or commercially available. Based on the literature, HAnps have outstanding physical, chemical, mechanical and biological properties that make them suitable for multiple interventions, in different domains of dental science. Further well-designed randomized controlled trials should be conducted in order to confirm all the achievements revealed by the in vitro or in vivo studies published until now. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites (Volume II))
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