Heterocycles in Drug Discovery
A topical collection in Drugs and Drug Candidates (ISSN 2813-2998). This collection belongs to the section "Medicinal Chemistry and Preliminary Screening".
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Interests: chemistry of heterocyclic compounds; microwave-assisted chemistry; sustainable methodologies; green chemistry applied to bioactive compounds: kinase inhibitors; Alzheimer's disease; down syndrome; cancer
Special Issues, Collections and Topics in MDPI journals
2. APHM, Pharmacy Department, Service Central de la Qualité et de l'Information Pharmaceutiques, 147 Bd Baille, 13005 Marseille, France
Interests: medicinal chemistry; heterocyclic chemistry; Plasmodium; Leishmania; Trypanosoma; nitroheterocycles
Special Issues, Collections and Topics in MDPI journals
Topical Collection Information
Dear Colleagues,
Heterocycles are crucial in drug discovery due to their high prevalence in biologically active compounds and pharmaceuticals. These ring structures, containing at least one atom other than carbon (commonly nitrogen, oxygen, or sulfur), constitute a unique opportunity to modulate diverse chemical and physical properties that enhance the interaction with biological targets. Their versatility allows for the design of molecules with improved potency, selectivity, and pharmacokinetic profiles. Many drugs, including antibiotics, antivirals, anticancer agents, and CNS drugs, feature heterocyclic moiety, underscoring their importance in the drug discovery process for developing effective and innovative therapeutics.
Prof. Dr. Thierry Besson
Dr. Nicolas Primas
Guest Editors
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Keywords
- drug discovery
- heterocycles
- medicinal chemistry
- bioisosteres
- physicochemical properties
- ADMET
- pharmacophore
- drug design
