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Diagnostics
Special Issues
Application of PET/CT in Diagnosis and Treatment of Cancers
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Application of PET/CT in Diagnosis and Treatment of Cancers

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1816

Special Issue Editor

Dr. Alberto Miceli

E-Mail Website
Guest Editor
Nuclear Medicine Unit, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy
Interests: PET; PET/CT; prostate cancer; tumor

Special Issue Information

Dear Colleagues,

PET/CT technology is a medical imaging technique that combines positron emission tomography (PET) and computed tomography (CT) to simultaneously provide functional and anatomical information. It has significant application value in cancer diagnosis and treatment.

On one hand, PET/CT can accurately locate a tumor’s position, size, and metastasis. Because PET/CT can detect metabolic activity in tumors, it has high sensitivity and specificity for early-stage tumors that are difficult to detect using conventional imaging techniques, such as lung cancer and lymphoma. On the other hand, PET/CT plays an important role in evaluating the therapeutic effect of tumors and adjusting treatment plans. By comparing the results of PET/CT scans before and after treatment, doctors can determine whether the tumor has responded to treatment and whether the treatment plan needs to be adjusted. In addition, PET/CT can also be used to look for signs of tumor recurrence and monitor the patient's condition changes.

18F-FDG is the commonly used tracer for PET imaging and has a wide range of applications in the diagnosis of various tumors. Other innovative tracers, such as fibroblast activation protein inhibitor (FAPI) or prostate-specific membrane antigen (PSMA), labeled with Gallium-68 or Fluor-18, can be complementary with 18F-FDG or be very accurate alone in certain types of tumors. In this Special Issue, we hope to show the latest progress in the application of various tracers in tumor diagnosis and treatment. We look forward to your submissions and participation in this exciting Special Issue.

Dr. Alberto Miceli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PET/CT
  • 18F-FDG
  • cancers
  • diagnosis
  • cancer treatment
 

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Published Papers (2 papers)

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Research

12 pages, 4246 KiB  
Article
Predictive Value of Quantitative Parameters of 18F-FDG PET/CT in Patients with Liposarcoma
by Lucia Martiniova, Serageldin Kamel, Kalevi Kairemo, Robert Benjamin, Neeta Somaiah, Gregory Ravizzini and Elise F. Nassif Haddad
Diagnostics 2024, 14(18), 2021; https://doi.org/10.3390/diagnostics14182021 - 12 Sep 2024
Viewed by 485
Abstract
The purpose of this study was to evaluate the predictive features of baseline F-18-fluorodeoxy-D-glucose positron emission tomography (18F-FDG PET)/computed tomography (CT) parameters in patients with dedifferentiated liposarcomas (DDLPSs) and well-differentiated liposarcomas (WDLPSs) receiving systemic treatment. A total of 24 patients with [...] Read more.
The purpose of this study was to evaluate the predictive features of baseline F-18-fluorodeoxy-D-glucose positron emission tomography (18F-FDG PET)/computed tomography (CT) parameters in patients with dedifferentiated liposarcomas (DDLPSs) and well-differentiated liposarcomas (WDLPSs) receiving systemic treatment. A total of 24 patients with liposarcoma who underwent longitudinal 18F-FDG PET/CT in systemic therapy were included. All volumetric segmentation of each tumor section and semiquantitative imaging parameters were extracted from the axial field of view from both PET and CT images. Maximum, mean, and minimum standardized uptake values (SUVmax, SUVmean, and SUVmin), Hounsfield units (HUs), and their respective changes from baseline and posttreatment were calculated. The voxel values from unenhanced CT images were correlated with PET-derived parameters. The 18F-FDG uptake decreased by more than 56% on average in responders for both SUVmax and SUVmean in DDLPS. There was a decrease in HUmax in DDLPS among responders. Using AUC > 0.8 as a reasonable predictor, we found that the ratios of SUVmaxD/HUmean, SUVmaxD/HUmedian, and SUVmeanD/HUmedian at baseline were significant indicators of the response to treatment in patients with liposarcoma. The changes in SUVmean and not just SUVmax parameters could be considered as accurate tumor response indicators. For the first time, we introduced baseline SUV/HU ratios as a valuable diagnostic tool in predicting liposarcoma treatment outcomes. This ability was not revealed by classic semiquantitative PET or CT parameters at baseline. Full article
(This article belongs to the Special Issue Application of PET/CT in Diagnosis and Treatment of Cancers)
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15 pages, 5601 KiB  
Article
18F-FDG PET/CT- and MRI-Based Locally Advanced Cervical Cancer Early-Response Assessment after Concurrent Chemo- and Radiotherapy—Impact on Patient Outcomes and Survival Prediction
by Silvija Lucic, Milena Spirovski, Dragana Stojanovic, Andrea Peter, Jelena Licina, Olivera Ivanov, Natasa Milenovic and Milos A. Lucic
Diagnostics 2024, 14(13), 1432; https://doi.org/10.3390/diagnostics14131432 - 4 Jul 2024
Viewed by 1046
Abstract
With one third of patients with locally advanced cervical cancer (LACC) expected to develop cancer recurrence in the first two years after therapy, accurate assessment of the response and timely detection of cancer recurrence after concurrent chemo- and radiotherapy (CCRT) treatment is of [...] Read more.
With one third of patients with locally advanced cervical cancer (LACC) expected to develop cancer recurrence in the first two years after therapy, accurate assessment of the response and timely detection of cancer recurrence after concurrent chemo- and radiotherapy (CCRT) treatment is of great importance. Although there is neither definite consensus about the preferred imaging modality, nor the time interval until the first diagnostic examination after CCRT, the National Comprehensive Cancer Network (NCCN) recommends the use of MRI and 18F-FDG PET/CT as a post-treatment LACC response-assessment imaging tools. In this study, we tried to appraise the early therapy response in LACC patients by both 18F-FDG PET/CT and MRI in regard to the follow-up imaging results and their mutual interrelationship, and to ascertain if the post-treatment 18F-FDG PET/CT and MRI results were related to the progression-free and overall survival rate in women with LACC after CCRT. We also aimed to estimate the early and follow-up diagnostic imaging impact on further therapy management. Based on our results, we concluded that 18F-FDG PET/CT did surpass MRI in the early assessment of therapeutic response in LACC patients after CCRT. Both modalities provided information that may serve as predictive biomarkers of outcome and LACC patients’ survival. Full article
(This article belongs to the Special Issue Application of PET/CT in Diagnosis and Treatment of Cancers)
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