Diagnosis and Management of Immunological, Allergic and Inflammatory Disorders

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 680

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue entitled “Diagnosis and Management of Immunological, Allergic and Inflammatory Disorders” focuses on recent advances in diagnosing and treating dysfunctions of the immune system. These pathologies comprising, among others, autoimmune, immunodeficiency and autoinflammatory syndromes, allergic diseases, and inflammatory disorders represent a considerable burden on individuals and societies alike.

In most people, a wide array of immune abnormalities can be found, not necessarily of clinical relevance but still representing real diagnostic challenge. Some of these disorders, however, can be life-threatening and should be diagnosed early to enable effective treatment. Unfortunately, for the time being, proper diagnosis cannot always be achieved easily, and thus, novel approaches to the diagnosis of immune system diseases are warranted.

This Special Issue aims to focus on topics dealing with the diagnostic challenges of these disorders and syndromes. Both original research articles and reviews are welcome.

Prof. Dr. Zenon Brzoza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • diagnostics
  • treatment
  • allergic diseases
  • autoimmune, immunodeficiency and autoinflammatory syndromes
  • inflammatory disorders

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Published Papers (1 paper)

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Review

17 pages, 1263 KiB  
Review
Integrative Cross-Talk in Asthma: Unraveling the Complex Interactions Between Eosinophils, Immune, and Structural Cells in the Airway Microenvironment
by Andrius Januskevicius, Egle Vasyle, Airidas Rimkunas and Kestutis Malakauskas
Diagnostics 2024, 14(21), 2448; https://doi.org/10.3390/diagnostics14212448 - 31 Oct 2024
Viewed by 569
Abstract
Asthma is a chronic inflammatory process that leads to airway narrowing, causing breath loss followed by spasms, wheezing, and shortness of breath. Within the asthmatic lungs, interaction among various immune cells and structural cells plays a significant role in orchestrating an inflammatory response [...] Read more.
Asthma is a chronic inflammatory process that leads to airway narrowing, causing breath loss followed by spasms, wheezing, and shortness of breath. Within the asthmatic lungs, interaction among various immune cells and structural cells plays a significant role in orchestrating an inflammatory response in which eosinophils hold central importance. In these settings, allergens or other environmental exposures commonly drive the immune response to recruit eosinophils to the airways. The appearance of eosinophils in the airways indicates a dynamic interplay of various cell types within lung tissue and does not represent a passive effect of inflammation. The cellular cross-talk causes the persistence of eosinophilic inflammation, and if left untreated, it results in long-term damage to the airway structure and function. Further exacerbation of the condition occurs because of this. We discuss how this complex interplay of eosinophils, immune, and structural cells within the airway microenvironment leads to the distinct pathophysiological features in asthma, the variability in disease severity, and the response to biological treatments. Full article
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