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Diagnostics
Special Issues
Screening and Diagnostic Testing of Keratoconus
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Screening and Diagnostic Testing of Keratoconus

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 973

Special Issue Editors

Dr. Cristina Nicula

E-Mail Website
Guest Editor
Department of Oral-Maxilo-Facial Surgery, Faculty of Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
Interests: cataract extraction; eye diseases; cataract; dry eye syndromes; presbyopia; blepharitis; keratoconjunctivitis sicca; keratoconus
Prof. Dr. Adriana Elena Bulboaca

E-Mail Website
Guest Editor
Pathophysiology Department, Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca, Cluj Napoca, Romania
Interests: nanomedicine; oxidative and nitrosative stress; inflammation; neuroophthalmology; ocular surface disorders mechanisms; retinal diseases mechanisms; nutraceuticals; translational medicine; personalized medicine

Special Issue Information

Dear Colleagues,

Keratoconus is a bilateral, asymmetric, ectatic corneal disorder characterized by progressive corneal thinning and steepening that may result in significant visual loss in the later stages. The disease onset is seen during the second decade of life, with fast evolution during this period. That is why the early detection and screening of keratoconus are crucial for disease management. To date, corneal topography has been the “gold standard” method of diagnosis. Moreover, corneal tomography is considered a better option for screening for the illness because it gives information on both the anterior and posterior surface of the cornea. Lately, corneal biomechanics provided by the Corvis device have highlighted the option for subclinical keratoconus diagnosis in the early stages of the illness.

Dr. Cristina Nicula
Prof. Dr. Adriana Elena Bulboaca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • keratoconus
  • eye diseases
  • vision problems
  • visual acuity test
  • refraction test
  • slit-lamp examination
  • tonometry
  • dilated fundus examination
  • visual field testing
  • anterior segment imaging
  • posterior segment imaging

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Published Papers (1 paper)

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Research

13 pages, 1879 KiB  
Article
Relationship between Choroidal Thickness and Anterior Scleral Thickness in Patients with Keratoconus
by Neus Burguera-Giménez, M.ª Amparo Díez-Ajenjo, Celeste Briceno-Lopez, Noemí Burguera, M.ª José Luque-Cobija and Cristina Peris-Martínez
Diagnostics 2024, 14(20), 2280; https://doi.org/10.3390/diagnostics14202280 - 14 Oct 2024
Viewed by 682
Abstract
Purpose: To evaluate the relationship between choroidal thickness (CT) and anterior scleral thickness (AST) in patients with subclinical keratoconus (SKC) and established keratoconus (KC). Methods: This single-center prospective case-control study included 97 eyes of 97 patients: 44 KC eyes, 14 SKC eyes, and [...] Read more.
Purpose: To evaluate the relationship between choroidal thickness (CT) and anterior scleral thickness (AST) in patients with subclinical keratoconus (SKC) and established keratoconus (KC). Methods: This single-center prospective case-control study included 97 eyes of 97 patients: 44 KC eyes, 14 SKC eyes, and 39 age- and axial length (AL)-matched healthy eyes. Using swept-source optical coherence tomography, the AST was manually measured in four directions and the CT was obtained automatically from the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. Principal component analysis (PCA) was used to linearly reduce the dimensionality of nine CT inputs to one significant component, CT1. A multivariate model was created to evaluate the association between CT1, AST, and several ocular parameters in SKC and KC patients. Partial correlation was then performed to adjust the confounding factors and to examine the effect of AST on CT1. Results: The PCA showed that CT1 accounts for 86.54% of the total variance in the nine original CTs of the ETDRS grid. The CT1 model was associated with age, AL, and AST in the superior meridian in SKC eyes, whereas in KC eyes, it was correlated with gender, age, AL, and AST in the inferior meridian (p < 0.001). The partial correlation between CT1 and AST in the superior zone was found to be significant, positive, and strong in SKC eyes (r = 0.79, p = 0.019), whereas a significant, positive, and moderate correlation between CT1 and AST at the inferior zone (r = 0.41, p = 0.017) was observed in KC eyes. Conclusions: Choroidal tissue was significantly correlated with the anterior sclera across the vertical meridian. This relationship was observed over the superior sclera in SKC eyes, whereas in established KC, it was over the inferior sclera. These results reveal new insights regarding the interactions between the anterior and posterior structures of the KC eyes and confirm the enigma of the pathophysiology of KC. Full article
(This article belongs to the Special Issue Screening and Diagnostic Testing of Keratoconus)
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