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Diagnostics
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Recent Advances in Malaria Diagnosis: 2nd Edition
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Recent Advances in Malaria Diagnosis: 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Diagnostic Microbiology and Infectious Disease".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 5496

Special Issue Editors

Dr. Maria Isabel Veiga

E-Mail Website
Guest Editor
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Interests: malaria; plasmodium falciparum; antimalarial drugs; resistance; epidemiology; diagnostics; molecular markers; hemozoin; drug transporters
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Weng Kung Peng

E-Mail Website
Guest Editor
Spin Dynamics in Health Engineering, Songshan Lake Materials Laboratory, Building A1, University Innovation Park, Songshan Lake, Dongguan 523808, China
Interests: precision medicine; NMR-based PoCT; machine learning
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

On behalf of Diagnostics, we invite you to submit a manuscript to our Special Issue entitled “Recent Advances in Malaria Diagnosis—Volume 2”.

Malaria is one of the deadliest infectious diseases and the COVID-19 pandemic has worsened the scenario. In addition to the enormous death toll, malaria also slows economic development and perpetuates the vicious cycle of poverty. Moreover, climate change is projected to result in malaria transmission in areas where it was not previously reported, calling for urgent action towards eliminating the disease. While the recently launched malaria vaccine provides a significant reduction in cases of deadly severe malaria, eliminating it requires prompt and accurate diagnosis allied with highly effective drug treatment. However, the challenges facing access to fast, reliable, and affordable diagnosis, and the ability to detect low-density infections form an immediate barrier to achieving the United Nations Sustainable Development Goals of ending malaria epidemics by the fast-approaching deadline of 2030.

It is generally accepted that an improved understanding of the parasite’s cell biology and pathogenesis combined with the advance in technology will support the development of innovative diagnostic tools to deliver highly sensitive and rapid field malaria detection.

This Special Issue discusses the recent advances of emerging technologies/methodologies in malaria diagnostics, the potentiality of moving beyond mere detection towards personalized malaria medicine, and envisioning point-of-care devices, enabling the approach towards the tantalizing notion of non-invasive, needle-free detection. Submissions can be original research articles, reviews, or commentaries/perspectives.

Dr. Maria Isabel Veiga
Prof. Dr. Weng Kung Peng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • malaria
  • diagnostic
  • low-density infection
  • sensitive
  • specific

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Related Special Issue

Published Papers (2 papers)

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Research

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10 pages, 963 KiB  
Article
Molecular Method Is Essential to Identify Asymptomatic Malaria Reservoirs: A Successful Experience in the Malaria Elimination Program in Iran
by Jebreil Shamseddin, Amin Ghanbarnejad, Abdoljabbar Zakeri, Farshid Abedi, Shaghayegh Khojasteh and Habibollah Turki
Diagnostics 2022, 12(12), 3025; https://doi.org/10.3390/diagnostics12123025 - 2 Dec 2022
Cited by 3 | Viewed by 2282
Abstract
Background: The accurate diagnosis of malaria cases, especially asymptotic and low-parasitemia patients, using robust molecular methods (nested-PCR) have been emphasized. The goal of this study was to detect active cases of malaria in areas with a history of local malaria transmission focusing on [...] Read more.
Background: The accurate diagnosis of malaria cases, especially asymptotic and low-parasitemia patients, using robust molecular methods (nested-PCR) have been emphasized. The goal of this study was to detect active cases of malaria in areas with a history of local malaria transmission focusing on the use of molecular tools to ensure that the malaria elimination program has been implemented successfully. Methods: In this cross-sectional study, 816 blood samples were taken from immigrants and local residents of malaria-endemic areas in Hormozgan province, Iran. In order to identify asymptomatic malaria parasite reservoirs, the samples were examined using microscopic, RDT, and nested-PCR techniques. Results: About twelve positive asymptomatic malaria cases were identified when the molecular method (nested-PCR) was used. The positivity rates among immigrants and local residents were 2.07% and 0.93%, respectively. No positive cases were detected using microscopic and RDT methods. Conclusions: The finding of the research emphasize that in addition to microscopy and RDTs methods, sensitive molecular tools as a standard and essential strategy are needed in the diagnosis and detection of asymptomatic parasite reservoir. Full article
(This article belongs to the Special Issue Recent Advances in Malaria Diagnosis: 2nd Edition)
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Review

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18 pages, 349 KiB  
Review
Urine and Saliva: Relevant Specimens for Malaria Diagnosis?
by Hwa Chia Chai and Kek Heng Chua
Diagnostics 2022, 12(12), 2989; https://doi.org/10.3390/diagnostics12122989 - 29 Nov 2022
Cited by 1 | Viewed by 2505
Abstract
Blood remains the specimen of preference for malaria diagnosis, whether it is for microscopic, nucleic acid-based or biomarker detection of Plasmodium present in a patient. However, concerning the disadvantages of blood drawing, specimens that can be non-invasively collected under non-hygienic settings would come [...] Read more.
Blood remains the specimen of preference for malaria diagnosis, whether it is for microscopic, nucleic acid-based or biomarker detection of Plasmodium present in a patient. However, concerning the disadvantages of blood drawing, specimens that can be non-invasively collected under non-hygienic settings would come in handy for malaria diagnosis in endemic areas with limited resources. Although the current approaches using saliva or urine might not be as sensitive and specific as using blood, the potential of these two specimens should not be underestimated and efforts in developing diagnostic methods for Plasmodium detection specifically in these two specimens should continue without giving up. This review not only compiles and summarizes the sensitivity and specificity achieved by various detection approaches when using these samples for malaria diagnosis, it also intends to enhance the possibility of using saliva and urine for diagnostic purposes by describing how Plasmodium nucleic acid and antigens may likely be present in these samples. This review may hopefully encourage and motivate researchers in developing saliva- and urine-based diagnostic methods for Plasmodium detection to facilitate the control and eradication of malaria. In summary, the presence of Plasmodium DNA and antigens in urine and saliva makes these two specimens relevant and useful for malaria diagnosis. Full article
(This article belongs to the Special Issue Recent Advances in Malaria Diagnosis: 2nd Edition)
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