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Diagnostics
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Diagnostic Imaging in Gastrointestinal and Liver Diseases
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Diagnostic Imaging in Gastrointestinal and Liver Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 2014

Special Issue Editors

Dr. Ruxandra Mare

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Guest Editor
1. Department of Internal Medicine II, Division of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
2. Advanced Regional Research Center in Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
Interests: liver diseases; portal hypertension; multiparametric ultrasound; elastography; contrast-enhanced ultrasound; endoscopic ultrasound
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ioan Sporea

E-Mail Website
Guest Editor
1. Advanced Regional Research Center in Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
2. Advanced Hepatology Research Center of the Medical Science Academy, 300223 Timisoara, Romania
Interests: liver cirrhosis; hepatitis; hepatocellular carcinoma; elastography; gastroenterology; liver diseases; viral hepatitis; ultrasound; hepatology; liver biopsy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to contribute to this Special Issue “Diagnostic Imaging in Gastrointestinal and Liver Diseases”.

Imaging is critical in the management of gastrointestinal and liver diseases because it allows for early detection, accurate diagnosis, and disease progression monitoring. A general approach for evaluating a patient with gastrointestinal or liver disease begins with either an endoscopy or an transabdominal ultrasound, followed by more sensitive imaging modalities used for the detection of structural changes, such as with endoscopic ultrasound, computer tomography, or MRI.

Over the last decade, we have witnessed an increase in non-invasive ultrasound techniques, such as contrast-enhanced ultrasound or elastography for evaluating the liver and advances in endoscopic ultrasound imaging (which have allowed us to better understand and diagnose gastrointestinal diseases).

This Special Issue, “Diagnostic Imaging in Gastrointestinal and Liver Diseases”, aims to include research that will advance current knowledge in this field. The papers should explore diagnostic challenges, present new challenges or validate existing ones, and provide new insights into how imaging can improve the health and quality of life in subjects with gastrointestinal and liver diseases.

In this Special Issue, original research articles, reviews, and case presentations are welcome.

We look forward to receiving your contributions.

Dr. Ruxandra Mare
Prof. Dr. Ioan Sporea
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ultrasonography
  • elastography
  • multiparametric ultrasound
  • contrast-enhanced ultrasound
  • endoscopic ultrasound
  • contrast-enhanced endoscopic ultrasound
  • computer tomography
  • magnetic resonance imaging, gastrointestinal diseases
  • diffuse liver disease
  • focal liver lesions

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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17 pages, 3140 KiB  
Article
Abbreviated Multiparametric MR Solution (the “Liver Triple Screen”), the Future of Non-Invasive MR Quantification of Liver Fat, Iron, and Fibrosis
by Gavin Low, Ryan K. W. Chee, Yu Jun Wong, Puneeta Tandon, Florin Manolea, Stephanie Locas, Craig Ferguson, Wendy Tu and Mitchell P. Wilson
Diagnostics 2024, 14(21), 2373; https://doi.org/10.3390/diagnostics14212373 - 24 Oct 2024
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Abstract
Background/Objectives: To review the findings of a multiparametric MRI (the “liver triple screen”) solution for the non-invasive assessment of liver fat, iron, and fibrosis in patients with chronic liver disease (CLD). Methods: A retrospective evaluation of all consecutive triple screen MRI cases was [...] Read more.
Background/Objectives: To review the findings of a multiparametric MRI (the “liver triple screen”) solution for the non-invasive assessment of liver fat, iron, and fibrosis in patients with chronic liver disease (CLD). Methods: A retrospective evaluation of all consecutive triple screen MRI cases was performed at our institution over the last 32 months. Relevant clinical, laboratory, and radiologic data were analyzed using descriptive statistics. Results: There were 268 patients, including 162 (60.4%) males and 106 (39.6%) females. The mean age was 54 ± 15.2 years (range 16 to 71 years). The most common cause of CLD was metabolic dysfunction-associated steatotic liver disease (MASLD) at 45.5%. The most common referring physician group was Gastroenterology at 62.7%. In 23.9% of cases, the reason for ordering the MRI was a pre-existing failed or unreliable US elastography. There were 17 cases (6.3%) of MRI technical failure. Our analysis revealed liver fibrosis in 66% of patients, steatosis in 68.3%, and iron overload in 22.1%. Combined fibrosis and steatosis were seen in 28.7%, steatosis and iron overload in 16.8%, fibrosis and iron overload in 6%, and combined fibrosis, steatosis, and iron overload in 4.1%. A positive MEFIB index, a predictor of liver-related outcomes, was found in 57 (27.5%) of 207 patients. Incidental findings were found in 14.9% of all MRIs. Conclusions: The liver triple screen MRI is an effective tool for evaluating liver fat, iron, and fibrosis in patients with CLD. It provides essential clinical information and can help identify MASLD patients at risk for liver-related outcomes. Full article
(This article belongs to the Special Issue Diagnostic Imaging in Gastrointestinal and Liver Diseases)
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5 pages, 3431 KiB  
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Atypical 18F-FDG PET-CT Findings in a Rare Case of Primary Hepatic Leiomyosarcoma
by Miju Cheon, Hyunkyung Yi, Joo Young Ha and Min A Kim
Diagnostics 2024, 14(14), 1502; https://doi.org/10.3390/diagnostics14141502 - 12 Jul 2024
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Abstract
The primary hepatic leiomyosarcoma is a rare malignant tumor arising from the smooth muscle cells in the hepatic vessels, bile ducts, and ligamentum teres. It is considered a subtype of hepatic sarcomas. We report awkward 18F-FDG PET-CT findings of a primary hepatic [...] Read more.
The primary hepatic leiomyosarcoma is a rare malignant tumor arising from the smooth muscle cells in the hepatic vessels, bile ducts, and ligamentum teres. It is considered a subtype of hepatic sarcomas. We report awkward 18F-FDG PET-CT findings of a primary hepatic leiomyosarcoma masquerading as a benign hepatic tumor, which were confirmed by histopathological and immunohistochemical examinations in a 78-year-old woman. Full article
(This article belongs to the Special Issue Diagnostic Imaging in Gastrointestinal and Liver Diseases)
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