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Diagnostics
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Gastroenterology and Hepatology: Diagnostics and Management
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Gastroenterology and Hepatology: Diagnostics and Management

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 4337

Special Issue Editor

Dr. Ishaan Vohra

E-Mail Website
Guest Editor
Department of Gastroenterology and Hepatology, University of Illinois College of Medicine, Peoria, IL 61637, USA
Interests: endoscopic retrograde cholangiopancreatography; endoscopic ultrasound; GI pathology national trends; third-space endoscopy; endoscopic suturing

Special Issue Information

Dear Colleagues,

We are excited to announce our upcoming Special Issue that aims to illuminate the ever-evolving landscape of interventional and general gastroenterology. This Issue will focus on key techniques, including Endoscopic Retrograde Cholangiopancreatography (ERCP), Endoscopic Ultrasound (EUS), Endoscopic Vacuum Therapy, Third-Space Endoscopy, and Endobariatric procedures, while also addressing nationwide trends in gastroenterology pathologies.

Our primary objective is to elevate patient care through pioneering research, innovative methodologies, and clinical insights that are reshaping the future of gastroenterological interventions. Contributions to this Special Issue will comprehensively delve into ERCP, spotlighting pioneering approaches for diagnosing and treating biliary and pancreatic disorders. EUS will take center stage, providing a platform to discuss refined techniques, procedural advancements, and emerging applications that directly impact patient outcomes. The exploration of Third-Space Endoscopy will unveil minimally invasive techniques for managing complex gastrointestinal conditions, emphasizing novel advancements and their potential to transform patient care.

Furthermore, the Special Issue will shed light on Endobariatric interventions, addressing the pressing need for effective weight management strategies. Cutting-edge research and clinical experiences will offer insights into the evolving landscape of endoscopic weight loss procedures.

This Special Issue will foster a collaborative environment for esteemed experts and researchers in the field of interventional gastroenterology. It serves as a vital platform for knowledge exchange, encouraging dialogue and collaborations that drive the field toward excellence.

We extend a warm invitation to authors from diverse disciplines within gastroenterology to contribute to this insightful and impactful Special Issue. Your contributions will enrich the discourse, advancing patient care and contributing to a healthier future. Together, let us embark on this journey of discovery and innovation in the realm of gastroenterology.

Dr. Ishaan Vohra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endoscopic retrograde cholangiopancreatography
  • endoscopic ultrasound
  • endo-bariatrics
  • national trends
  • third-space endoscopy

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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15 pages, 1304 KiB  
Article
Racial Disparities in Inpatient Hospital Outcomes of Primary Sclerosing Cholangitis in United States: Nationwide Analysis
by Ishaan Vohra, Harishankar Gopakumar, Dushyant Singh Dahiya, Michel Kahaleh and Neil Sharma
Diagnostics 2024, 14(22), 2493; https://doi.org/10.3390/diagnostics14222493 - 7 Nov 2024
Viewed by 494
Abstract
Background: Primary sclerosing cholangitis (PSC) is an idiopathic cholestatic liver disease that may lead to biliary strictures and destruction. It is associated with p-ANCA positivity and inflammatory bowel disease, typically ulcerative colitis. The aim of this study is to investigate the trends of [...] Read more.
Background: Primary sclerosing cholangitis (PSC) is an idiopathic cholestatic liver disease that may lead to biliary strictures and destruction. It is associated with p-ANCA positivity and inflammatory bowel disease, typically ulcerative colitis. The aim of this study is to investigate the trends of inpatient healthcare utilization and mortality from 2008 to 2017 in the United States. Methods: The Nationwide Inpatient Sample (NIS) was examined to identify adult patients diagnosed with PSC between 2008 and 2017. Data on patient demographics, resource utilization, mortality, and PSC-related complications were collected. STATA version 16.0 was employed to perform forward stepwise multivariate regression analysis, generating adjusted odds ratios for both primary and secondary outcomes. Primary outcomes included the inpatient mortality rate and healthcare resource utilization (length of stay, total charges, and trends over the study period). Secondary outcomes focused on trends in associated comorbidities and malignancies in patients with PSC. Results: The average total charge increased by 32.2% ± 2.12 from USD 61,873 ± 2567 in 2008 to USD 91,262 ± 2961 in 2017. Concurrently, the average length of stay declined from 8.07 ± 0.18 days in 2008 to 7.27 ± 0.13 days in 2017. The APR-DRG severity of illness and risk of death significantly increased (major or extreme) during the study period (2008 to 2017), with severity rising from 73.6% to 82.7% (coefficient: 0.21, 95% CI: 0.13–0.28) and risk of death from 45.3% to 60.9% (coefficient: 0.15, 95% CI: 0.08–0.23). The proportion of patients with HCC increased from 1.3% to 7.9% (coefficient: 2.13, 95% CI: 1.9–2.8). Conversely, the percentage of patients with cholangiocarcinoma (CCA) decreased from 5.1% to 2.8% (coefficient: −0.36, 95% CI: −0.25 to −0.46). Conclusions: There was rising mortality and healthcare resource utilization among patients with PSC from the years 2008 to 2017. These trends were paralleled by increasing rates of decompensated cirrhosis, HCC, and liver transplants. However, the incidence of CCA decreased during this time period. African American patients with PSC had worse inpatient mortality outcomes and healthcare utilization as compared to white patients. Further studies are warranted to investigate a possible causal link amongst these trends. Full article
(This article belongs to the Special Issue Gastroenterology and Hepatology: Diagnostics and Management)
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11 pages, 2092 KiB  
Article
A Simple Clinical Scoring System to Determine the Risk of Pancreatic Cancer in the General Population
by Dai Yoshimura, Mitsuharu Fukasawa, Yoshioki Yoda, Masahiko Ohtaka, Tadao Ooka, Shinichi Takano, Satoshi Kawakami, Yoshimitsu Fukasawa, Natsuhiko Kuratomi, Shota Harai, Naruki Shimamura, Hiroyuki Hasegawa, Naoto Imagawa, Yuichiro Suzuki, Takashi Yoshida, Shoji Kobayashi, Mitsuaki Sato, Tatsuya Yamaguchi, Shinya Maekawa and Nobuyuki Enomoto
Diagnostics 2024, 14(6), 651; https://doi.org/10.3390/diagnostics14060651 - 20 Mar 2024
Viewed by 1150
Abstract
This study aimed to develop and validate a simple scoring system to determine the high-risk group for pancreatic cancer (PC) in the asymptomatic general population. The scoring system was developed using data from PC cases and randomly selected non-PC cases undergoing annual medical [...] Read more.
This study aimed to develop and validate a simple scoring system to determine the high-risk group for pancreatic cancer (PC) in the asymptomatic general population. The scoring system was developed using data from PC cases and randomly selected non-PC cases undergoing annual medical checkups between 2008 and 2013. The performance of this score was validated for participants with medical checkups between 2014 and 2016. In the development set, 45 PC cases were diagnosed and 450 non-PC cases were identified. Multivariate analysis showed three changes in clinical data from 1 year before diagnosis as independent risk factors: ΔHbA1c ≥ 0.3%, ΔBMI ≤ −0.5, and ΔLDL ≤ −20 mg/dL. A simple scoring system, incorporating variables and abdominal ultrasound findings, was developed. In the validation set, 36 PC cases were diagnosed over a 3-year period from 32,877 participants. The AUROC curve of the scoring system was 0.925 (95%CI 0.877–0.973). The positive score of early-stage PC cases, including Stage 0 and I cases, was significantly higher than that of non-PC cases (80% vs. 6%, p = 0.001). The simple scoring system effectively narrows down high-risk PC cases in the general population and provides a reasonable approach for early detection of PC. Full article
(This article belongs to the Special Issue Gastroenterology and Hepatology: Diagnostics and Management)
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Review

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19 pages, 14763 KiB  
Review
Imaging of the Liver and Pancreas: The Added Value of MRI
by Giovanni Morana, Alessandro Beleù, Luca Geraci, Luisa Tomaiuolo and Silvia Venturini
Diagnostics 2024, 14(7), 693; https://doi.org/10.3390/diagnostics14070693 - 26 Mar 2024
Viewed by 2386
Abstract
MR is a powerful diagnostic tool in the diagnosis and management of most hepatic and pancreatic diseases. Thanks to its multiple sequences, the use of dedicated contrast media and special techniques, it allows a multiparametric approach able to provide both morphological and functional [...] Read more.
MR is a powerful diagnostic tool in the diagnosis and management of most hepatic and pancreatic diseases. Thanks to its multiple sequences, the use of dedicated contrast media and special techniques, it allows a multiparametric approach able to provide both morphological and functional information for many pathological conditions. The knowledge of correct technique is fundamental in order to obtain a correct diagnosis. In this paper, different MR sequences will be illustrated in the evaluation of liver and pancreatic diseases, especially those sequences which provide information not otherwise obtainable with other imaging techniques. Practical MR protocols with the most common indications of MR in the study of the liver and pancreas are provided. Full article
(This article belongs to the Special Issue Gastroenterology and Hepatology: Diagnostics and Management)
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