Vascular Diagnostic Imaging

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2515

Special Issue Editor


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Guest Editor
Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Seoul, Republic of Korea
Interests: heart failure; hypertension; myocarditis; wearable device; echocardiography

Special Issue Information

Dear Colleagues,

With the advancement of imaging tests, many vascular diagnostic imaging techniques are available for use clinically. Given this opportunity, I would like to discuss research on flow-mediated dilation (FMD) and intravascular ultrasound (IVUS)/optical coherence tomography (OCT). FMD is a noninvasive vascular function test that measures changes in artery diameter in response to reactive hyperemia. This indicates that endothelial function is a predictor of cardiovascular events such as cardiac death, myocardial infarction, and stroke. IVUS-guided PCI (percutaneous coronary intervention) and OCT-guided PCI are increasingly being implemented globally; this is an area in which many research results have been published recently. This Special Issue welcomes reviews of the research conducted so far on FMD and IVUS/OCT and studies which introduce new research in terms of these techniques.

Dr. Hyo-Suk Ahn
Guest Editor

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Keywords

  • flow-mediated dilation (FMD)
  • optical coherence tomography (OCT)
  • intravascular ultrasound (IVUS)

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Published Papers (3 papers)

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Research

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9 pages, 394 KiB  
Article
Concordance between Coronary Artery Computed Tomography and Invasive Coronary Angiography in a Real-World Population with Suspected Chronic Coronary Syndrome
by Lucia Barbieri, Gabriele Tumminello, Guido Pasero, Carlo Avallone, Andrea D’Errico, Luca Mircoli, Federico Colombo, Cecilia Gobbi, Nello Manuel Bellissimo, Massimiliano Ruscica and Stefano Carugo
Diagnostics 2024, 14(17), 1905; https://doi.org/10.3390/diagnostics14171905 - 29 Aug 2024
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Abstract
Background: Coronary computed tomographic angiography (CCTA) is a non-invasive imaging technique that possesses the ability to provide detailed anatomical information about coronary arteries, avoiding unnecessary invasive procedures. Our aim was to assess the ability of CCTA to identify coronary artery disease compared to [...] Read more.
Background: Coronary computed tomographic angiography (CCTA) is a non-invasive imaging technique that possesses the ability to provide detailed anatomical information about coronary arteries, avoiding unnecessary invasive procedures. Our aim was to assess the ability of CCTA to identify coronary artery disease compared to invasive coronary angiography (ICA) in a real-life setting. Methods: We examined 137 consecutive patients who underwent ICA after CCTA. The latter was conducted in various non-selected centers, and data regarding stenosis were taken from individual reports without further analysis. Results: A total of 60.5% of patients who underwent CCTA were found to have at least one critical stenosis, while the remaining 39.5% underwent ICA due to concurrent clinical or instrumental indications. Among these, 29.5% had angiographically critical pathology, 20.3% underwent a percutaneous coronary intervention (PCI), and 1.8% had coronary artery bypass grafting. Among the 83 patients with positive CCTA results, 34.9% had negative ICA findings. CCTA demonstrated low sensitivity (57.8%) and a positive predictive value of 42.6%. However, it retained high specificity (83.6%) and a negative predictive value of 90.4% for identifying critical stenosis. Among the 18.2% of patients who underwent CCTA without a specific indication, 60% had critical coronary lesions on their ICA and 86.6% of these subsequently underwent a PCI. Conclusions: CCTA performed in non-selective centers has a low concordance with ICA. Full article
(This article belongs to the Special Issue Vascular Diagnostic Imaging)
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Review

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15 pages, 1343 KiB  
Review
A Comprehensive Review of Clinical Studies Applying Flow-Mediated Dilation
by Yuran Ahn, Nay Aung and Hyo-Suk Ahn
Diagnostics 2024, 14(22), 2499; https://doi.org/10.3390/diagnostics14222499 - 8 Nov 2024
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Abstract
Flow-mediated dilation (FMD) is a noninvasive method to evaluate vascular endothelial function, which manifests the vascular inflammatory response, cell proliferation, and autoregulation. Since FMD is noninvasive and assesses commonly in the brachial artery by ultrasound, compared to other invasive methods such as optical [...] Read more.
Flow-mediated dilation (FMD) is a noninvasive method to evaluate vascular endothelial function, which manifests the vascular inflammatory response, cell proliferation, and autoregulation. Since FMD is noninvasive and assesses commonly in the brachial artery by ultrasound, compared to other invasive methods such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), it is widely used to evaluate endothelial function and allows serial assessment. In this review, we present the currently accepted mechanisms and methods of FMD measurement with the studies applied in the current clinical practice using FMD. After all, the association with cardiovascular diseases is of substance, and so we introduce clinical studies of FMD related to cardiovascular disease such as diabetes, hyperlipidemia, chronic kidney disease, coronary artery disease, and peripheral vascular disease. In addition, studies related to pregnancy and COVID-19 were also inspected. Yet, endothelial examination is not endorsed as a cardiovascular prevention measure, for the lack of a clear standardized value methodology. Still, many studies recommend practicable FMD and would be a better prognostic value in the cardiovascular prognosis in future clinical research. Full article
(This article belongs to the Special Issue Vascular Diagnostic Imaging)
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14 pages, 1277 KiB  
Review
Perivascular Fat: A Novel Risk Factor for Coronary Artery Disease
by Spyridon Simantiris, Aikaterini Pappa, Charalampos Papastamos, Panagiotis Korkonikitas, Charalambos Antoniades, Constantinos Tsioufis and Dimitris Tousoulis
Diagnostics 2024, 14(16), 1830; https://doi.org/10.3390/diagnostics14161830 - 22 Aug 2024
Viewed by 1331
Abstract
Perivascular adipose tissue (PVAT) interacts with the vascular wall and secretes bioactive factors which regulate vascular wall physiology. Vice versa, vascular wall inflammation affects the adjacent PVAT via paracrine signals, which induce cachexia-type morphological changes in perivascular fat. These changes can be quantified [...] Read more.
Perivascular adipose tissue (PVAT) interacts with the vascular wall and secretes bioactive factors which regulate vascular wall physiology. Vice versa, vascular wall inflammation affects the adjacent PVAT via paracrine signals, which induce cachexia-type morphological changes in perivascular fat. These changes can be quantified in pericoronary adipose tissue (PCAT), as an increase in PCAT attenuation in coronary computed tomography angiography images. Fat attenuation index (FAI), a novel imaging biomarker, measures PCAT attenuation around coronary artery segments and is associated with coronary artery disease presence, progression, and plaque instability. Beyond its diagnostic capacity, PCAT attenuation can also ameliorate cardiac risk stratification, thus representing an innovative prognostic biomarker of cardiovascular disease (CVD). However, technical, biological, and anatomical factors are weakly related to PCAT attenuation and cause variation in its measurement. Thus, to integrate FAI, a research tool, into clinical practice, a medical device has been designed to provide FAI values standardized for these factors. In this review, we discuss the interplay of PVAT with the vascular wall, the diagnostic and prognostic value of PCAT attenuation, and its integration as a CVD risk marker in clinical practice. Full article
(This article belongs to the Special Issue Vascular Diagnostic Imaging)
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