Biomarkers and Clinical Imaging for Diagnosis, Prevention and Management of Muscle Decay

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 2385

Special Issue Editors


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Guest Editor
School of Physical Medicine and Rehabilitation, Department of Neuroscience, University of Padova, Padua, Italy
Interests: genetic and acquired skeletal muscle disorders; mobility functional tests; skeletal muscle imaging; quantitative tissue densitometry by 3D and 2D color CT and MRI; blood and mouth fluid biomarkers; targeted management and follow-up in mobility medicine; functional electrical stimulation of denervated and reinnervating muscles; home full-body in-bed gym exercise; spa, thermal, and balneotherapy; hemi-fasting and other nutritional supplements of mobility medicine in aging
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Guest Editor
1. Department of Kinesitherapy, Medical University of Sofia, Sofia, Bulgaria
2. Faculty of Dental Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria
Interests: translational myologythis

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Guest Editor
International FES Centre®, Swiss Paraplegic Center, CH-6207 Nottwil, Switzerland
Interests: improvement of hand function, improvement of bowel management; secure skin integrity to prevent pressure injuries

Special Issue Information

Dear Colleagues,

The 2023 Padua Days of Muscle and Mobility Medicine (2023 PDM3), held from 29 March to 1 April 2023, was a meeting of scientists and clinicians from all over the world to share the state of the art in the development of rapid diagnostics in support of sustainable health in human and animal muscle or neuromuscular disorders. The event covered 40 hours of programming while allowing everyone worldwide to join freely for the ZOOM circulation of events from the Conference Halls of the Hotel Petrarca of the Thermae of Euganean Hills, Padua, Italy.

There were 13 Sessions during the 2023 PDM3:

  1. SESSION I: Adaptations to Physical Exercise in Aging: from Cell to Functioning;
  2. SESSION II: Skeletal Muscle Epigenetics and the Dark Side of the Genome;
  3. Session III: Adaptations in Aging: from Molecules to Functioning;
  4. Session IV: FES Managements of Acquired Muscle Diseases;
  5. SESSION V: Genetic Muscle Diseases;
  6. SESSION VI: Twenty Years of Italian Association of Myologists (AIM);
  7. SESSION VII: Senescence and Rejuvenation;
  8. Session VIII: Muscle Fascia, Biology and Pathology;
  9. SESSION IX: Non-invasive Assessments in Myology;
  10. SESSION X: Muscle Rehabilitation in Dentistry and Practical Course on Diagnosis and Functional Analysis of the Stomatognathic System;
  11. SESSION XI: LBI Workshop on Muscle Rehabilitation: from Mouse to Elderly;
  12. SESSION XII: AMB-REMOB: Results of an Early Outpatient Rehabilitation Program;
  13. SESSION XIII: European Medical Thermalism and the World Federation Hydrotherapy (FEMTEC).

More than 150 senior and young myologists attended invited lectures, seniors' oral presentations and young researchers’ short talks at the 2023 Padua Days of Muscle and Mobility Medicine.

I hope that many of them will submit their results, especially those relating to the diagnostic aspects of their research, to the 2023 and 2024 MDPI Diagnostics Special Issue on Biomarkers and Clinical Imaging for Diagnosis, Prevention and Management of Muscle Decay.

All accepted papers will soon be e-published and forwarded to PubMed.

Prof. Dr. Ugo Carraro
Dr. Jannis Papathanasiou
Dr. Ines Bersch
Guest Editors

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Published Papers (1 paper)

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Research

12 pages, 661 KiB  
Article
Reliability and Agreement Assessment of Sarcopenia Diagnosis through Comparison of Bioelectrical Impedance Analysis and Dual-Energy X-ray Absorptiometry
by Jung Hun Lee, Hee Jin Kim, Sanghun Han, Seong Jun Park, Myongheon Sim and Kang Hyun Lee
Diagnostics 2024, 14(9), 899; https://doi.org/10.3390/diagnostics14090899 - 25 Apr 2024
Viewed by 1746
Abstract
A unified diagnostic criterion has yet to be established for sarcopenia. Therefore, we analyzed the reliability and validity of sarcopenia diagnosis using bioelectrical impedance analysis (BIA) compared with the gold standard, dual-energy X-ray absorptiometry (DEXA), and evaluated the predictive accuracy of BIA for [...] Read more.
A unified diagnostic criterion has yet to be established for sarcopenia. Therefore, we analyzed the reliability and validity of sarcopenia diagnosis using bioelectrical impedance analysis (BIA) compared with the gold standard, dual-energy X-ray absorptiometry (DEXA), and evaluated the predictive accuracy of BIA for diagnosis. The clinical trial, involving a total of 239 participants, was conducted between December 2018 and September 2019 on healthy volunteers without significant medical histories. The participants underwent health assessments, followed by sequential DEXA and BIA measurements. In both the low and normal appendicular skeletal muscle (ASM) groups, there were significant differences in the right arm, left arm, right leg, left leg, ASM, and ASM index (ASMI) between DEXA and BIA across all age groups (p < 0.05). BIA tended to overestimate compared to DEXA, but ASMI values for males and females were consistent with the criteria for sarcopenia. Bland–Altman analysis showed that each segment in both the low and normal ASM groups fell within the limits of agreement (LOA). The diagnosis of sarcopenia using BIA was significantly different from that using DEXA. However, it exhibited a significantly high correlation, fell within the LOA, and demonstrated high predictive accuracy. BIA can be considered an effective tool for diagnosing sarcopenia. Full article
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