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Fermentation
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Production of Added-Value Products from Renewable Resources and Engineered Cell...
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Production of Added-Value Products from Renewable Resources and Engineered Cell Factories

A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Industrial Fermentation".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 10809

Special Issue Editor

Dr. Donatella Cimini

E-Mail Website
Guest Editor
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi, 43 81100 Caserta, Italy
Interests: metabolic engineering; microbial fermentation; microbial glycosaminoglycans (GAGs) and GAG-like polysaccharides; chondroitin; bioprocess development from lab to pilot scale; probiotics; organic acids; waste biomass valorization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The growing concerns about the depletion of fossil fuels and their impact on the environment, together with the affirmation of circular economy principles such as “zero waste”, currently place a considerable emphasis on the development of industrial processes that recover and recycle waste materials to be converted into high-added-value chemical and biological products. This is particularly valid for waste generated by the agricultural production and food processing industries, which can be used as raw material for the development of sustainable biotechnological processes to create real “biorefineries”.

Therefore, with the aim to support initiatives relating to the development of a circular economy, parallel actions are needed to establish competitive production pathways and which aim, on the one hand, to restructure the microbial metabolism and design metabolic pathways which maximize the production of high-added-value target molecules, and on the other hand, to invest in the study of more sustainable fermentation processes based on the use of renewable raw materials.

This Special Issue is open to manuscripts that embrace these themes.

Dr. Donatella Cimini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

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18 pages, 2864 KiB  
Article
Bioproduction of 2-Phenylethanol by Yarrowia lipolytica on Sugar Beet Molasses as a Low-Cost Substrate
by Sara Mitri, Nicolas Louka, Tristan Rossignol, Richard G. Maroun and Mohamed Koubaa
Fermentation 2024, 10(6), 290; https://doi.org/10.3390/fermentation10060290 - 30 May 2024
Cited by 1 | Viewed by 1191
Abstract
2-phenylethanol (2-PE) is a valuable aromatic alcohol with diverse applications in cosmetics, food, beverages, and pharmaceutical industries. Currently, 2-PE is produced either through chemical synthesis or by extraction from plant materials. However, both conventional production methods have their own limitations. Therefore, there is [...] Read more.
2-phenylethanol (2-PE) is a valuable aromatic alcohol with diverse applications in cosmetics, food, beverages, and pharmaceutical industries. Currently, 2-PE is produced either through chemical synthesis or by extraction from plant materials. However, both conventional production methods have their own limitations. Therefore, there is a need for more eco-friendly and cost-effective approaches to produce natural 2-PE. Biotechnological routes, particularly microbial fermentations, hold promise for natural 2-PE production, especially when using low-cost substrates. In this study, 2-PE was produced by de novo synthesis via the shikimate pathway, using the yeast Yarrowia lipolytica in a medium composed of sugar beet molasses (SBM) and yeast extract (YE) as carbon and nitrogen sources, respectively. A genetically engineered strain was generated, in which the SUC2 gene was transformed, expressing the invertase enzyme, enabling Y. lipolytica to efficiently utilize SBM as a cost-effective substrate. A central composite design allowed for the optimization of the concentrations of the carbon and nitrogen sources, resulting in approximately 0.71 g(2-PE)/L(culture medium). The results obtained highlight the potential of utilizing SBM as a low-cost substrate for 2-PE production, advancing biotechnological approaches in fragrance synthesis. Full article
(This article belongs to the Special Issue Production of Added-Value Products from Renewable Resources and Engineered Cell Factories)
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15 pages, 5154 KiB  
Article
Lactic Acid Production by Enterococcus durans Is Improved by Cell Recycling and pH Control
by Raissa Gabriela Martins Reis Barroso, Mônica Caramez Triches Damaso, Fabricio Machado and Sílvia Belém Gonçalves
Fermentation 2024, 10(3), 149; https://doi.org/10.3390/fermentation10030149 - 6 Mar 2024
Cited by 1 | Viewed by 1770
Abstract
Lactic acid bacteria are widely used because they produce lactic acid naturally, are resistant to acidic pH and a wide temperature range, and frequently produce lactic acid as a primary metabolite. In this study, Enterococcus durans isolated from buffalo milk was employed in [...] Read more.
Lactic acid bacteria are widely used because they produce lactic acid naturally, are resistant to acidic pH and a wide temperature range, and frequently produce lactic acid as a primary metabolite. In this study, Enterococcus durans isolated from buffalo milk was employed in lactic acid fermentation with the primary goal of obtaining fermentation parameters for an effective process enabling the use of lactose as an alternative carbon source. Fermentative parameters such as initial concentration of carbon source, dissolved oxygen concentration, cell recycling, and batch with pulse operation mode were studied to find the best conditions for L-(+)-lactic acid production. The association of 20 g·L−1 of lactose with 10 g·L−1 of glucose enabled the best bioconversion to lactic acid. Anaerobiosis did not contribute to increasing lactic acid production. Batch fermentation with cell recycling was the strategy that enhanced lactic acid production and lactose consumption, reaching 26.07 g·L−1, 0.36 g·L−1·h−1 of productivity and yielding about 0.86 g·g−1. It is fundamental to evaluate the parameters of lactic acid fermentation and provide efficient and sustainable production methods. Full article
(This article belongs to the Special Issue Production of Added-Value Products from Renewable Resources and Engineered Cell Factories)
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15 pages, 2812 KiB  
Article
Novel Technologies for Butyric Acid Fermentation: Use of Cellulosic Biomass, Rapid Bioreactor, and Efficient Product Recovery
by Nasib Qureshi, Richard D. Ashby, Nancy N. Nichols and Ronald Hector
Fermentation 2024, 10(3), 142; https://doi.org/10.3390/fermentation10030142 - 1 Mar 2024
Viewed by 1990
Abstract
Butyric acid, a four-carbon fatty acid, is an important industrial chemical and feedstock. To produce this chemical, a control fermentation was run with a 126.5 g.L−1 glucose concentration in the feed medium. In this medium, the strain produced 44.8 g.L−1 total [...] Read more.
Butyric acid, a four-carbon fatty acid, is an important industrial chemical and feedstock. To produce this chemical, a control fermentation was run with a 126.5 g.L−1 glucose concentration in the feed medium. In this medium, the strain produced 44.8 g.L−1 total acid with a productivity of 0.23 g.L−1h−1 and a yield of 0.41 g.g−1. The strain (Clostridium tyrobutyricum ATCC 25755) was also able to utilize glucose and xylose simultaneously with similar fermentation performance. The culture was also used to produce butyric acid from wheat straw hydrolysate (WSH) employing a hot water pretreatment. In a batch system, the strain resulted in a productivity and yield of 0.27 g.L−1h−1 and 0.44 g.g−1, respectively, which was an improvement over the use of glucose or xylose alone or mixtures of both. To improve reactor productivity, a membrane cell recycle bioreactor was used which resulted in a productivity of 1.89 g.L−1h−1. This productivity was 822% of that achieved in the glucose or xylose batch fermentation. Furthermore, a butyric acid recovery method was developed using XAD-4 adsorbent resin. In this system, up to 206.1 g.L−1 of butyric acid was used in the feed and, as a result of the quick adsorption, the residual butyric acid concentration was 29.5 g.L−1. In this experiment, the rate of acid removal of 1059.4 g.L−1h−1 was achieved. Full article
(This article belongs to the Special Issue Production of Added-Value Products from Renewable Resources and Engineered Cell Factories)
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Review

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31 pages, 9619 KiB  
Review
Bacterial Nanocellulose Produced by Cost-Effective and Sustainable Methods and Its Applications: A Review
by Siriporn Taokaew
Fermentation 2024, 10(6), 316; https://doi.org/10.3390/fermentation10060316 - 14 Jun 2024
Viewed by 2643
Abstract
This review discusses the recent advancements in cost-effective fermentation methods for producing bacterial nanocellulose (BC) from food and agro-industrial waste. Achieving economical cell culture media is crucial for large-scale BC production, requiring nutrient-rich media at low cost to maximize cellulose yield. Various pretreatment [...] Read more.
This review discusses the recent advancements in cost-effective fermentation methods for producing bacterial nanocellulose (BC) from food and agro-industrial waste. Achieving economical cell culture media is crucial for large-scale BC production, requiring nutrient-rich media at low cost to maximize cellulose yield. Various pretreatment methods, including chemical, physical, and biological approaches, are stated to break down waste into accessible molecules for cellulose-producing bacteria. Additionally, strategies such as dynamic bioreactors and genetic engineering methods are investigated to enhance BC production. This review also focuses on the environmental impact assessment and updated application challenges of BC such as medical applications, energy storage/electronics, filtration membranes, and food packaging. By providing insights from the recent literature findings, this review highlights the innovative potential and challenges in economically and efficiently producing BC from waste streams. Full article
(This article belongs to the Special Issue Production of Added-Value Products from Renewable Resources and Engineered Cell Factories)
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22 pages, 713 KiB  
Review
Unlocking the Potential of Mannosylerythritol Lipids: Properties and Industrial Applications
by Joana Dias de Almeida, Miguel Figueiredo Nascimento, Petar Keković, Frederico Castelo Ferreira and Nuno Torres Faria
Fermentation 2024, 10(5), 246; https://doi.org/10.3390/fermentation10050246 - 9 May 2024
Cited by 3 | Viewed by 2501
Abstract
Mannosylerythritol lipids (MELs), one of the most promising biosurfactants (BS), are glycolipids produced by yeasts or fungi, which have great environmental performance and high compatibility with the human body. MELs, besides working as typical surfactants, can form diverse structures when at or above [...] Read more.
Mannosylerythritol lipids (MELs), one of the most promising biosurfactants (BS), are glycolipids produced by yeasts or fungi, which have great environmental performance and high compatibility with the human body. MELs, besides working as typical surfactants, can form diverse structures when at or above the critical aggregation concentration (CAC), reduce the surface tension of water and other solutions, and be stable over a wide range of conditions. Among others, MELs present antimicrobial, antitumor, antioxidant and anti-inflammatory activities and skin and hair repair capacity, which opens possibilities for their use in applications from cosmetics and pharmaceutics to bioremediation and agriculture. However, their market share is still low when compared to other glycolipids, due to their less developed production process and higher production cost. This review gathers information on the potential applications of MELs mentioned in the literature since 1993. Furthermore, it also explores the current strategies being developed to enhance the market presence of MELs, in parallel with the ones developed for rhamnolipids and sophorolipids. Full article
(This article belongs to the Special Issue Production of Added-Value Products from Renewable Resources and Engineered Cell Factories)
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