Specialized Metabolites from Actinomycetes: From Gene to Product and Back
A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Microbial Metabolism, Physiology & Genetics".
Deadline for manuscript submissions: closed (31 January 2016) | Viewed by 5532
Special Issue Editor
Interests: actinomycetes; natural products; antibiotics; resistome; glycopeptides; lantibiotics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Among living organisms, filamentous actinomycetes still represent one of the most interesting sources for the discovery of novel, bioactive microbial products, also known as secondary or specialized metabolites. It is estimated that two-thirds of currently used antibiotics originate from the Streptomyces genus, and 45% of described specialized metabolites are produced by filamentous actinomycetes, including increasing numbers of bioactive glycopeptides, lantibiotics, and polketides, which are produced by uncommon genera of non-streptomyces actinomycetes. The ever-increasing number of sequenced microbial genomes, which unveil the distribution and diversity of gene clusters that encode the novel biosynthetic pathways (or interesting variants of those already described) that produce bioactive microbial products, confirm the primary role of this bacterial group in the discovery and development of novel drugs. A parallel in-depth understanding of the tight regulatory networks that control specialized metabolite production in these organisms (in response to diverse environmental and intracellular signals) is triggering the development of novel fermentation processes and strain improvement approaches, which can complement and/or replace the traditional ones currently in use in industrial environments. In this Special Issue, we invite authors to submit original research and review articles that address our understanding of, and eventually address, the current bottlenecks in the process of fermentation and the strain improvement of novel and old specialized metabolites from actinomycetes.
Prof. Dr. Flavia Marinelli
Guest Editor
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Keywords
- actinomycetes
- fermentation
- strain improvement
- recombinant engineering
- specialized metabolites
- antibiotics
- elicitors
- heterologus expression
- genome mining
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