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Gastroenterology Insights
Special Issues
Feature Papers in Celiac Disease
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Feature Papers in Celiac Disease

A special issue of Gastroenterology Insights (ISSN 2036-7422). This special issue belongs to the section "Gastrointestinal Disease".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 3875

Special Issue Editor

Dr. Alessandro Granito

E-Mail Website1 Website2
Guest Editor
1. Associate Professor, Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
2. Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Interests: hepatocellular carcinoma; liver cancer; autoimmune hepatitis; primary biliary cholangitis; primary sclerosing cholangitis; celiac disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Celiac disease has seen several developments over the past 10 years that deserve a timely review. The key issues are (1) the increasing prevalence of the disease and new epidemiological data; (2) recent developments related to the introduction of non-biopsy diagnostic strategy; (3) the impact of the extraintestinal and non-classical clinical manifestations of celiac disease; (4) the difficulties in adhering to the gluten-free diet, with potential problems related to patients' social life and quality of life; (5) disease complications and their risk factors; (6) new treatment approaches.

This Special Issue on celiac disease accepts articles from basic and preclinical research, clinical research, case series or case reports of clinical impact, short communications, and review articles.

This Special Issue welcomes but is not limited to the following topics:

  • Epidemiology of celiac disease;
  • Non-biopsy diagnosis of celiac disease;
  • Extraintestinal manifestations of celiac disease;
  • Celiac disease-associated diseases;
  • Dietary issues for 21st century patients;
  • Neoplastic and non-neoplastic complications;
  • New therapies: Drugs and vaccines.

Dr. Alessandro Granito
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gastroenterology Insights is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • celiac disease
  • gluten-free diet
  • serological markers
  • autoantibodies
  • non-biopsy diagnosis
  • complications

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

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9 pages, 258 KiB  
Article
The Effect of Body Composition on Osteoporosis Risk in Adults with Celiac Disease
by Kinga Skoracka, Michał Michalak, Alicja Ewa Ratajczak-Pawłowska, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska and Iwona Krela-Kaźmierczak
Gastroenterol. Insights 2024, 15(4), 895-903; https://doi.org/10.3390/gastroent15040062 - 4 Oct 2024
Viewed by 690
Abstract
Background: Celiac disease (CD) has been linked with increased susceptibility to osteoporosis; therefore, we aimed to explore whether, in a group of patients with CD, body composition parameters impact bone parameters. Methods: This study covered 56 adults—47 women and 9 men—with CD, and [...] Read more.
Background: Celiac disease (CD) has been linked with increased susceptibility to osteoporosis; therefore, we aimed to explore whether, in a group of patients with CD, body composition parameters impact bone parameters. Methods: This study covered 56 adults—47 women and 9 men—with CD, and 20 healthy controls—16 women and 4 men. Densitometry of the lumbar spine (L1–L4) and femoral neck (FN) was conducted using dual-energy X-ray absorptiometry (DXA). Body mass was measured by bioimpedance method. Furthermore, serum 25(OH)D and ionized calcium concentration were determined. Results: We found osteopenia in the FN in 19.65% of patients and in L1–L4 in 26.79% of the patients. One patient displayed evidence of osteoporosis in the L1–L4 region, while two patients (3.57%) exhibited similar findings in the FN. Significant positive correlations were observed between bone mineral density (BMD) and body mass, fat-free mass (FFM), muscle mass, and basal metabolic rate (BMR) for both L1–L4 and the FN, and body mass index (BMI) of L1–L4. Conclusions: In conclusion, people with CD are at an increased risk of decreased BMD. Patients with lower body mass, FFM, muscle mass, BMI, and BMR more often present with osteopenia and osteoporosis. Full article
(This article belongs to the Special Issue Feature Papers in Celiac Disease)

Review

Jump to: Research

17 pages, 1053 KiB  
Review
Nutritional Consequences of Celiac Disease and Gluten-Free Diet
by Paola Ilaria Bianchi, Nicola Aronico, Giovanni Santacroce, Giacomo Broglio, Marco Vincenzo Lenti and Antonio Di Sabatino
Gastroenterol. Insights 2024, 15(4), 878-894; https://doi.org/10.3390/gastroent15040061 - 27 Sep 2024
Viewed by 2749
Abstract
Celiac disease is an immune-mediated condition triggered by gluten ingestion in genetically predisposed individuals. The global prevalence of celiac disease is significant, affecting approximately 1.4% of women and 0.7% of men, with incidence rates of 17.4 and 7.8 per 100,000 person-years, respectively. The [...] Read more.
Celiac disease is an immune-mediated condition triggered by gluten ingestion in genetically predisposed individuals. The global prevalence of celiac disease is significant, affecting approximately 1.4% of women and 0.7% of men, with incidence rates of 17.4 and 7.8 per 100,000 person-years, respectively. The clinical presentation of celiac disease may range from overt diarrhea and malabsorption to more subtle features such as nutritional deficiencies and extraintestinal manifestations. It is the most common cause of global malabsorption in Western countries. A life-long gluten-free diet is the only available treatment for celiac disease. Moreover, a gluten-free diet is often adopted by individuals without celiac disease, either to address non-celiac gluten sensitivity or for other reasons. This review aims to explore the current understandings of the nutritional consequences of untreated celiac disease and the impact of the gluten-free diet itself. Physicians and dietitians specializing in celiac disease should focus on providing a well-rounded nutritional scheme to address deficiencies caused by the disease and prevent the instauration of new nutritional imbalances. Full article
(This article belongs to the Special Issue Feature Papers in Celiac Disease)
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