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Gels
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Bioprinting Hydrogels
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Bioprinting Hydrogels

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 14616

Special Issue Editors

Dr. Jason L. Guo

E-Mail Website
Guest Editor
Department of Surgery, Stanford University, Stanford, CA 94305, USA
Interests: fibrosis; wound healing; bioinformatics; machine learning; 3D printing; bioprinting
Prof. Dr. Michael T. Longaker

E-Mail Website
Guest Editor
Department of Surgery, Stanford University, Stanford, CA 94305, USA
Interests: fibrosis; wound healing; skeletal development; stem cell biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Three-dimensional (3D) printing technologies have empowered hydrogel and scaffold fabrication, supporting research in tissue engineering, regenerative medicine, drug delivery, and more. Bioprinting, a subset of 3D printing, utilizes biomaterials, cells, and/or physiologically relevant factors to produce user-defined biological constructs. Compared to traditional hydrogel fabrication techniques, bioprinting offers exceptionally greater control over physical structure and spatial patterning of hydrogel components. Ultimately, the emergence of bioprinting has empowered material scientists, tissue engineers, clinicians, and others to develop hydrogels with significantly greater biomedical utility.

This Special Issue on “Bioprinting Hydrogels” is dedicated to recent advances in the development, characterization, and biological applications of 3D printed hydrogels.

The Guest Editors of this Special Issue welcome submissions that encompass the breadth and depth of research on hydrogel bioprinting. Original research articles, methods articles, and review papers will be considered for publication. The areas of interest include, but are not limited to:

  • Bioprinting of complex structures;
  • Bioprinting of multiple materials and composites;
  • Spatial patterning of ligands;
  • Controlled release from 3D printed gels;
  • Stimuli-responsive hydrogels;
  • Computational modeling of 3D printed gels;
  • In vitro and in vivo characterization of 3D printed gels.

Dr. Jason L. Guo
Prof. Dr. Michael T. Longaker
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioprinting
  • hydrogels
  • composite
  • spatial patterning
  • controlled release
  • stimuli-responsive
  • computational modeling

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Published Papers (3 papers)

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Research

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12 pages, 1786 KiB  
Article
Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy
by Kelsey H. Collins, Lara Pferdehirt, Leila S. Saleh, Alireza Savadipour, Luke E. Springer, Kristin L. Lenz, Dominic M. Thompson, Jr., Sara J. Oswald, Christine T. N. Pham and Farshid Guilak
Gels 2023, 9(2), 169; https://doi.org/10.3390/gels9020169 - 20 Feb 2023
Cited by 8 | Viewed by 4461
Abstract
Biologic therapies have revolutionized treatment options for rheumatoid arthritis (RA) but their continuous administration at high doses may lead to adverse events. Thus, the development of improved drug delivery systems that can sense and respond commensurately to disease flares represents an unmet medical [...] Read more.
Biologic therapies have revolutionized treatment options for rheumatoid arthritis (RA) but their continuous administration at high doses may lead to adverse events. Thus, the development of improved drug delivery systems that can sense and respond commensurately to disease flares represents an unmet medical need. Toward this end, we generated induced pluripotent stem cells (iPSCs) that express interleukin-1 receptor antagonist (IL-1Ra, an inhibitor of IL-1) in a feedback-controlled manner driven by the macrophage chemoattractant protein-1 (Ccl2) promoter. Cells were seeded in agarose hydrogel constructs made from 3D printed molds that can be injected subcutaneously via a blunt needle, thus simplifying implantation of the constructs, and the translational potential. We demonstrated that the subcutaneously injected agarose hydrogels containing genome-edited Ccl2-IL1Ra iPSCs showed significant therapeutic efficacy in the K/BxN model of inflammatory arthritis, with nearly complete abolishment of disease severity in the front paws. These implants also exhibited improved implant longevity as compared to the previous studies using 3D woven scaffolds, which require surgical implantation. This minimally invasive cell-based drug delivery strategy may be adapted for the treatment of other autoimmune or chronic diseases, potentially accelerating translation to the clinic. Full article
(This article belongs to the Special Issue Bioprinting Hydrogels)
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Review

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30 pages, 4361 KiB  
Review
Nanocomposite Bioprinting for Tissue Engineering Applications
by Konstantinos Loukelis, Zina A. Helal, Antonios G. Mikos and Maria Chatzinikolaidou
Gels 2023, 9(2), 103; https://doi.org/10.3390/gels9020103 - 24 Jan 2023
Cited by 26 | Viewed by 5323
Abstract
Bioprinting aims to provide new avenues for regenerating damaged human tissues through the controlled printing of live cells and biocompatible materials that can function therapeutically. Polymeric hydrogels are commonly investigated ink materials for 3D and 4D bioprinting applications, as they can contain intrinsic [...] Read more.
Bioprinting aims to provide new avenues for regenerating damaged human tissues through the controlled printing of live cells and biocompatible materials that can function therapeutically. Polymeric hydrogels are commonly investigated ink materials for 3D and 4D bioprinting applications, as they can contain intrinsic properties relative to those of the native tissue extracellular matrix and can be printed to produce scaffolds of hierarchical organization. The incorporation of nanoscale material additives, such as nanoparticles, to the bulk of inks, has allowed for significant tunability of the mechanical, biological, structural, and physicochemical material properties during and after printing. The modulatory and biological effects of nanoparticles as bioink additives can derive from their shape, size, surface chemistry, concentration, and/or material source, making many configurations of nanoparticle additives of high interest to be thoroughly investigated for the improved design of bioactive tissue engineering constructs. This paper aims to review the incorporation of nanoparticles, as well as other nanoscale additive materials, to printable bioinks for tissue engineering applications, specifically bone, cartilage, dental, and cardiovascular tissues. An overview of the various bioinks and their classifications will be discussed with emphasis on cellular and mechanical material interactions, as well the various bioink formulation methodologies for 3D and 4D bioprinting techniques. The current advances and limitations within the field will be highlighted. Full article
(This article belongs to the Special Issue Bioprinting Hydrogels)
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13 pages, 2071 KiB  
Review
Bioprinted Hydrogels for Fibrosis and Wound Healing: Treatment and Modeling
by Jason L. Guo and Michael T. Longaker
Gels 2023, 9(1), 19; https://doi.org/10.3390/gels9010019 - 27 Dec 2022
Cited by 11 | Viewed by 4111
Abstract
Three-dimensional (3D) printing has been used to fabricate biomaterial scaffolds with finely controlled physical architecture and user-defined patterning of biological ligands. Excitingly, recent advances in bioprinting have enabled the development of highly biomimetic hydrogels for the treatment of fibrosis and the promotion of [...] Read more.
Three-dimensional (3D) printing has been used to fabricate biomaterial scaffolds with finely controlled physical architecture and user-defined patterning of biological ligands. Excitingly, recent advances in bioprinting have enabled the development of highly biomimetic hydrogels for the treatment of fibrosis and the promotion of wound healing. Bioprinted hydrogels offer more accurate spatial recapitulation of the biochemical and biophysical cues that inhibit fibrosis and promote tissue regeneration, augmenting the therapeutic potential of hydrogel-based therapies. Accordingly, bioprinted hydrogels have been used for the treatment of fibrosis in a diverse array of tissues and organs, including the skin, heart, and endometrium. Furthermore, bioprinted hydrogels have been utilized for the healing of both acute and chronic wounds, which present unique biological microenvironments. In addition to these therapeutic applications, hydrogel bioprinting has been used to generate in vitro models of fibrosis in a variety of soft tissues such as the skin, heart, and liver, enabling high-throughput drug screening and tissue analysis at relatively low cost. As biological research begins to uncover the spatial biological features that underlie fibrosis and wound healing, bioprinting offers a powerful toolkit to recapitulate spatially defined pro-regenerative and anti-fibrotic cues for an array of translational applications. Full article
(This article belongs to the Special Issue Bioprinting Hydrogels)
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