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Gels
Special Issues
Advanced Gel Materials for Bioengineering
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Advanced Gel Materials for Bioengineering

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 2145

Special Issue Editors

Dr. Shuhui Yang

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
Interests: hydrogels; biomaterials; tissue engineering; regenerative medicine
Dr. Haibo Mu

E-Mail Website
Guest Editor
College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, China
Interests: drug delivery; biomedical hydrogels; bacterial infection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce this Special Issue on “Advanced Gel Materials for Bioengineering”, which aims to showcase the latest advancements and breakthroughs in the field of gel materials and their applications in biomedical engineering.

Gel materials have gained significant attention in recent years due to their unique properties and versatile applications in the biomedical field. These materials, characterized by their ability to swell and retain large amounts of water within their network, offer numerous advantages for various bioengineering applications, including drug delivery, tissue engineering, regenerative medicine, and biosensing.

This Special Issue provides an excellent platform to present and discuss the design, synthesis, characterization, and utilization of gel materials for various bioengineering applications. We invite researchers and experts to contribute original research articles and comprehensive reviews that focus on the development and application of innovative gel-based materials in the field of bioengineering.

Topics of interest include but are not limited to:

  1. Novel synthesis methods for gel materials;
  2. Functionalization and surface modification of gel materials;
  3. Controlled drug delivery systems using gel materials;
  4. Gel-based scaffolds for tissue engineering and regenerative medicine;
  5. Responsive and stimuli-sensitive gel materials;
  6. Gel materials for biosensing and diagnostic applications;
  7. Biocompatibility and biodegradability of gel materials;
  8. Translational studies and clinical applications of gel materials.

We look forward to receiving your contributions and believe that this Special Issue will contribute significantly to the advancement of gel materials in bioengineering and foster collaborations within the scientific community.

Dr. Shuhui Yang
Dr. Haibo Mu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gel material
  • synthesis and characterization
  • bioengineering
  • tissue engineering
  • drug delivery
  • biosensing
  • diagnosis

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Published Papers (2 papers)

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19 pages, 5230 KiB  
Article
Development and Characterization of Niaprazine-Loaded Xanthan Gum-Based Gel for Oral Administration
by Elena Giuliano, Emanuela Longo, Agnese Gagliardi, Silvia Costa, Federica Squillace, Silvia Voci, Mario Verdiglione and Donato Cosco
Gels 2025, 11(2), 101; https://doi.org/10.3390/gels11020101 - 1 Feb 2025
Viewed by 217
Abstract
Niaprazine is a sedative-hypnotic drug initially developed as an antihistamine and used for its notable sedative effects, particularly in children. Following its withdrawal from the market by the producer, the drug has been administered as magistral formulations available in syrup form, but there [...] Read more.
Niaprazine is a sedative-hypnotic drug initially developed as an antihistamine and used for its notable sedative effects, particularly in children. Following its withdrawal from the market by the producer, the drug has been administered as magistral formulations available in syrup form, but there are several important disadvantages to this, including instability, taste issues, lack of controlled release, and the potential for unreliable dosing due to incomplete swallowing. There is also an increased risk of dental caries, as well as the fact that these formulations are not suitable for children who suffer from diabetes. The purpose of the current investigation is to prepare and characterize xanthan gum-based gels for the oral administration of niaprazine. Niaprazine gels appear as transparent-whiteish, non-sticky substances, with the drug uniformly dispersed throughout the systems. They are also stable over time. Dynamic rheology revealed their advantageous shear-thinning properties, which enable the formulation to be flexibly dosed orally through administration via syringe. During experimentation, the evaluation of the mucoadhesion features and the in vitro drug release profile were also performed. The results demonstrate that the formulation may represent an alternative to niaprazine syrup, allowing easy preparation, administration, and increased compliance in various categories of patients, including pediatric. Full article
(This article belongs to the Special Issue Advanced Gel Materials for Bioengineering)
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Review

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14 pages, 632 KiB  
Review
Hydrogel-Based Vascularized Organ Tissue Engineering: A Systematized Review on Abdominal Organs
by Filippos F. Karageorgos, Maria Alexiou, Georgios Tsoulfas and Aleck H. Alexopoulos
Gels 2024, 10(10), 653; https://doi.org/10.3390/gels10100653 - 12 Oct 2024
Cited by 1 | Viewed by 1480
Abstract
Background: Biomedical engineering, especially tissue engineering, is trying to provide an alternative solution to generate functional organs/tissues for use in various applications. These include beyond the final goal of transplantation, disease modeling and drug discovery as well. The aim of this study is [...] Read more.
Background: Biomedical engineering, especially tissue engineering, is trying to provide an alternative solution to generate functional organs/tissues for use in various applications. These include beyond the final goal of transplantation, disease modeling and drug discovery as well. The aim of this study is to comprehensively review the existing literature on hydrogel-based vascularized organ (i.e., liver, pancreas, kidneys, intestine, stomach and spleen) tissue engineering of the abdominal organs. Methods: A comprehensive literature search was conducted on the Scopus database (latest search 1 September 2024). The research studies including hydrogel-based vascularized organ tissue engineering in the organs examined here were eligible for the review. Results: Herein, 18 studies were included. Specifically, 10 studies included the liver or hepatic tissue, 5 studies included the pancreas or pancreatic islet tissue, 3 studies included the kidney or renal tissue, 1 study included the intestine or intestinal or bowel tissue, 1 study included the stomach or gastric tissue, and 0 studies included spleen tissue. Conclusion: Hydrogels are biocompatible materials with ideal characteristics for use as scaffolds. Even though organ tissue engineering is a rapidly growing field, there are still many obstacles to overcome to create a fully functional and long-lasting organ. Full article
(This article belongs to the Special Issue Advanced Gel Materials for Bioengineering)
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