The Impact of Epigenetics on Development, Regeneration and Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (15 April 2021) | Viewed by 21512
Special Issue Editors
Interests: DNA methylation; epigenetic damage; transposons; regeneration; cancer; liver; zebrafish
Special Issue Information
Dear Colleagues,
The epigenome is implicated in nearly every aspect of cell behavior and identity. Both local and genome-wide alterations to the epigenome contribute to processes as diverse as development and cancer. A combinatorial code of epigenetic modifications regulates gene expression and provides a map for genome organization and nuclear structure. Integration of these regulatory functions of the epigenome is important for forming new cells in embryos and during tissue regeneration. These same features dramatically change in cancer cells. The functional impact of epigenetic modifications and widespread reshaping of the epigenome is critical for development, regeneration, and during carcinogenesis, and, in many cases, the same factors regulate all three of these processes.
This Issue will highlight novel insights regulating developmental and regenerative processes and cover fundamental aspects of epigenetic regulation that contribute to development and cancer. The articles will showcase the range of model systems that have been used to generate our current understanding of the epigenetic impact on development, regeneration, and cancer.
The epigenome has traditionally been studied in the context of cell identity, and in recent years, the role of epigenetic patterns in dictating regenerative capacity, regulating the cell cycle, and suppressing transposable elements during development, regeneration, and cancer have been a focus. There is an emerging understanding of how a combination of epigenetic modifications shape genome organization, and serve as central to the mechanisms by which epigenetic changes contribute to cancer.
Integrated genomics approaches combined with advanced imaging provide a global view of the epigenome in developmental systems, during regeneration and in cancer. This Special Issue will cover recent discoveries that integrate genomics, novel model organisms, and imaging approaches to uncover how the epigenome is patterned in developing and regenerating cells and how this pattern becomes co-opted by cancer cells to advance malignancy. Implications for developing therapeutics that target the epigenome will be reviewed. Reviews and short communications are encouraged.
Prof. Dr. Kirsten Sadler Edepli
Prof. Dr. Elena Ezhkova
Guest Editors
Manuscript Submission Information
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Keywords
- epigenetics
- chromatin
- stem cells
- regeneration
- cancer
- model organisms
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