Novel Insights in the Pathophysiology and Management of Diabetes-Related Complications
A special issue of Healthcare (ISSN 2227-9032).
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 2242
Special Issue Editor
Interests: diabetes mellitus; obesity; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic surgery; body composition; cardiovascular disease; insulin resistance; mitochondrial function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diabetes mellitus represents a complex multifactorial syndrome characterized by abnormalities in every single aspect of cellular energy metabolism. Over its natural course, it can be complicated by serious comorbidities which affect multiple organs and systems such as the cardiovascular, nervous and gastrointestinal systems, kidneys, skin, mental and psychological health and others. According to recent data from the International Diabetes Federation, an estimated 463 million adults are currently living with diabetes globally. If current trends continue, this number is projected to nearly double by the year 2030, making diabetes the contemporary metabolic pandemic. Type 1 diabetes mellitus (T1DM), associated with reduced endogenous insulin secretion as a result of autoimmune destruction of insulin-producing pancreatic β-cells, is currently experiencing an increase in its incidence, possibly due to the elevated childhood obesity rates. Type 2 diabetes mellitus (T2DM), associated with the combined presence of both insulin resistance and defective insulin secretion, makes up about 85-90% of all cases, and the alarming increase in its global prevalence relates to the aging population and the increasing rates of obesity and sedentary lifestyle. Diabetes-related multifaceted complications represent one of the leading causes of morbidity and mortality worldwide and limit diabetic patients’ life expectancy. Cardiorenal complications in particular are the leading cause of death among patients with diabetes.
Typical complications of T1DM and T2DM comprise microvascular complications such as retinopathy, nephropathy and neuropathy, and macrovascular complications including stroke, ischemic heart disease and peripheral artery disease. Beyond these classical vascular complications, diabetes has been further associated with a large number of other clinically relevant complications such as non-alcoholic fatty liver disease and especially non-alcoholic steatohepatitis (NASH), depression, cognitive impairment in the form of either vascular dementia or Alzheimer’s disease, hypoglycemia as a result of antidiabetic treatment, increased susceptibility to infections (including COVID-19 disease) and malignancies. These complications may significantly disrupt patients’ quality of life and pose a substantial burden for patients, societies and healthcare systems. The major pathophysiological mechanisms underlying diabetes-related complications involve insulin resistance, gluco- and lipotoxicity, accumulation of advanced glycation end products (AGEs), impaired mitochondrial function in several tissues, subclinical inflammation, oxidative stress, endothelial dysfunction and cellular senescence pathways.
This Special Issue invites the submission of original research and review articles related to any of the diabetes-related complications mentioned above, both in terms of pathophysiological mechanisms and current treatment approaches. The broad scope of this Special Issue reflects the broad spectrum of diabetes-related complications and gives a great opportunity to generate an updated article collection providing an overview of the most recent developments in understanding the major pathophysiological traits implicated in diabetes-related complications, and recent breakthroughs in treatment options for these potentially life-threatening diabetes-related health risks.
Dr. Chrysi Koliaki
Guest Editor
Manuscript Submission Information
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Keywords
- type 1 diabetes mellitus
- type 2 diabetes mellitus
- complications
- microvascular complications
- macrovascular complications
- non-alcoholic steatohepatitis
- cardiovascular disease
- insulin resistance
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