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Editorial Board Members' Collection Series: Age-Related Cognitive Decline and Neurodegenerative...
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Editorial Board Members' Collection Series: Age-Related Cognitive Decline and Neurodegenerative Disorders

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Aging".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 3755

Special Issue Editors

Dr. Giuseppe Lanza

E-Mail Website
Guest Editor
1. Clinical Neurophysiology Research Unit, Oasi Research Institute-IRCCS, Troina, Italy
2. Department of Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy
Interests: cerebrovascular diseases; cognitive impairment and dementia; neuropsychiatric disorders; sleep disorders; gluten-related neuropathology; clinical neurophysiology; transcranial magnetic stimulation; neurosonology; neuroplasticity; translational neurosciences
Special Issues, Collections and Topics in MDPI journals
Dr. Rónán O’Caoimh

E-Mail Website
Guest Editor
Department of Geriatric Medicine, Mercy University Hospital, Grenville Place, T12 WE28 Cork, Ireland
Interests: mild cognitive impairment; Alzheimer’s disease; dementia; geriatric medicine; frailty
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dementia is a leading cause of death worldwide. Associated with aging, its prevalence is expected to grow in line with global demographic trends. Alzheimer’s disease and Parkinson’s disease are the most common neurodegenerative diseases. Disorders such as these are strongly associated with cognitive symptoms, which vary according to the stage of the disease. Increasingly, prodromal stages are recognized, such as mild cognitive impairment. In addition to increased healthcare needs, physical decline, frailty and higher economic costs, persons experiencing symptoms of cognitive impairment have a lower quality of life. These conditions also impact negatively upon the lives of their family and friends, who often experience significant strain providing care and support. It is increasingly recognized that the causes of neurodegenerative disorders are multi-factorial, such that a person’s genes, lifestyle and environment all contribute to their risk of developing cognitive impairment and neurodegenerative disease, as well as the risk of progression. Despite a greater understanding of these conditions over recent years, scientists still have a lot of work to do to better prevent, assess, diagnose and treat these aged-related disorders.

We are pleased to announce this Collection, titled “Editorial Board Members' Collection Series: Age-Related Cognitive Decline and Neurodegenerative Disorders”. This Issue will be a collection of papers from researchers invited by the Editorial Board Members. The aim is to provide a venue for networking and communication between IJERPH and scholars in the field of age-related cognitive decline and neurodegenerative disorders. All papers will be published with full open access after peer review.

Dr. Giuseppe Lanza
Dr. Rónán O’Caoimh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • cognitive decline
  • neurodegenerative disorder
  • Alzheimer’s disease
  • Parkinson's disease
  • dementia
  • mild cognitive impairment
  • neurogenetics
  • cerebrovascular disease
  • prevention
  • drugs
  • nutraceuticals
  • non-pharmacological interventions
  • caregiver burden, cognitive frailty

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Published Papers (2 papers)

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Research

14 pages, 1115 KiB  
Article
Validation of a Harmonised, Three-Item Cognitive Screening Instrument for the Survey of Health, Ageing and Retirement in Europe (SHARE-Cog)
by Mark R. O’Donovan, Nicola Cornally and Rónán O’Caoimh
Int. J. Environ. Res. Public Health 2023, 20(19), 6869; https://doi.org/10.3390/ijerph20196869 - 30 Sep 2023
Cited by 1 | Viewed by 1717
Abstract
More accurate and standardised screening and assessment instruments are needed for studies to better understand the epidemiology of mild cognitive impairment (MCI) and dementia in Europe. The Survey of Health, Ageing and Retirement in Europe (SHARE) does not have a harmonised multi-domain cognitive [...] Read more.
More accurate and standardised screening and assessment instruments are needed for studies to better understand the epidemiology of mild cognitive impairment (MCI) and dementia in Europe. The Survey of Health, Ageing and Retirement in Europe (SHARE) does not have a harmonised multi-domain cognitive test available. The current study proposes and validates a new instrument, the SHARE cognitive instrument (SHARE-Cog), for this large European longitudinal cohort. Three cognitive domains/sub-tests were available across all main waves of the SHARE and incorporated into SHARE-Cog; these included 10-word registration, verbal fluency (animal naming) and 10-word recall. Subtests were weighted using regression analysis. Diagnostic accuracy was assessed from the area under the curve (AUC) of receiver operating characteristic curves. Diagnostic categories included normal cognition (NC), subjective memory complaints (SMC), MCI and dementia. A total of 20,752 participants were included from wave 8, with a mean age of 75 years; 55% were female. A 45-point SHARE-Cog was developed and validated and had excellent diagnostic accuracy for identifying dementia (AUC = 0.91); very good diagnostic accuracy for cognitive impairment (MCI + dementia), (AUC = 0.81); and good diagnostic accuracy for distinguishing MCI from dementia (AUC = 0.76) and MCI from SMC + NC (AUC = 0.77). SHARE-Cog is a new, short cognitive screening instrument developed and validated to assess cognition in the SHARE. In this cross-sectional analysis, it has good–excellent diagnostic accuracy for identifying cognitive impairment in this wave of SHARE, but further study is required to confirm this in previous waves and over time. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Age-Related Cognitive Decline and Neurodegenerative Disorders)
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10 pages, 342 KiB  
Article
Spatio-Temporal Gait Parameters of Hospitalized Older Patients: Comparison of Fallers and Non-Fallers
by Emilie Bourgarel, Clémence Risser, Frederic Blanc, Thomas Vogel, Georges Kaltenbach, Maxence Meyer and Elise Schmitt
Int. J. Environ. Res. Public Health 2023, 20(5), 4563; https://doi.org/10.3390/ijerph20054563 - 4 Mar 2023
Cited by 2 | Viewed by 1376
Abstract
Gait disorders are predisposing factors for falls. They are accessible to rehabilitation and can be analyzed using tools that collect spatio-temporal parameters of walking, such as the GAITRite® mat. The objective of this retrospective study was to find differences between the spatio-temporal [...] Read more.
Gait disorders are predisposing factors for falls. They are accessible to rehabilitation and can be analyzed using tools that collect spatio-temporal parameters of walking, such as the GAITRite® mat. The objective of this retrospective study was to find differences between the spatio-temporal parameters in patients who had fallen compared to patients who did not fall in a population of older patients hospitalized in acute geriatrics department. Patients over 75 years were included. For each patient, spatio-temporal parameters were collected using the GAITRite® mat. The patients were divided into two groups according to whether they had a history of fall. The spatio-temporal parameters were compared between the two groups and in relation to the general population. Sixty-seven patients, with an average age of 85.9 ± 6 years, were included. The patients had comorbidities, cognitive impairment and were polymedicated. The mean walking speed was 51.4 cm/s in non-fallers group and 47.3 cm/s in fallers group (p = 0.539), indicating pathological walking in comparison with the general population of the same age (average 100 cm/s). No association was found between the spatio-temporal parameters and fall, probably linked to many confounding factors such as the pathogenicity of walking of our patients and their comorbidities. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Age-Related Cognitive Decline and Neurodegenerative Disorders)
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