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Diabetes Mellitus and Frailty
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Diabetes Mellitus and Frailty

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 10853

Special Issue Editors

Dr. Aaron Liew

E-Mail Website
Guest Editor
Department of Medicine, University of Galway, Galway, Ireland
Interests: angiology; vascular medicine; diabetes; internal medicine; frailty
Special Issues, Collections and Topics in MDPI journals
Dr. Rónán O'Caoimh

E-Mail Website
Guest Editor
Mercy University Hospital, Grenville Place, Cork City T12 WE28, Ireland
Interests: frailty; cognitive impairment and diabetes in later life
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetes mellitus (DM) is a disabling, chronic cardiovascular and medical condition which represents a tremendous health, social, and economic challenge for our ageing societies. Frailty, a complex multidimensional health state of increased vulnerability to stressors with an attenuated capacity to maintain homeostasis, is increasingly recognised as an important predictor of disability, mortality and institutionalisation among older adults with DM. Frailty can progress but can sometimes improve over time. DM often coexists with frailty increasing the risk-adverse health and social care outcomes, while increasing costs and reducing quality of life.

This special collection will bring together papers that focus on the current epidemiology of DM and frailty, the relationship between DM and frailty and their impact on morbidity and mortality. It will also examine models of care and potential approaches to prevent or reverse frailty in people with DM. 

Dr. Aaron Liew
Dr. Rónán O'Caoimh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Diabetes mellitus
  • Frailty
  • Epidemiology
  • Model of care
  • Quality of life

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Published Papers (2 papers)

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17 pages, 2466 KiB  
Article
The Impact of and Interaction between Diabetes and Frailty on Psychosocial Wellbeing and Mortality in Ireland
by Mark O’Donovan, Duygu Sezgin, Rónán O’Caoimh and Aaron Liew
Int. J. Environ. Res. Public Health 2020, 17(24), 9535; https://doi.org/10.3390/ijerph17249535 - 19 Dec 2020
Cited by 6 | Viewed by 3176
Abstract
Frailty in middle-aged and older adults is associated with diabetes-related complications. The impact of and interaction between diabetes and frailty on psychosocial wellbeing and mortality in Ireland for adults aged ≥50 years were assessed using data from the Survey of Health, Ageing and [...] Read more.
Frailty in middle-aged and older adults is associated with diabetes-related complications. The impact of and interaction between diabetes and frailty on psychosocial wellbeing and mortality in Ireland for adults aged ≥50 years were assessed using data from the Survey of Health, Ageing and Retirement in Europe. Measures included diabetes status (self-reported), frailty phenotype (≥3/5 criteria), low self-rated health (“fair” or “poor”), depression screening (EURO-D index score ≥4), and low quality of life (QoL) (CASP-12 index score < 35). Among the 970 participants, those with diabetes (n = 87) were more likely to be frail (23% vs. 8%; p < 0.001), have low self-rated health (46% vs. 19%; p < 0.001), depression (25% vs. 17%; p = 0.070), and low QoL (25% vs. 18%, p = 0.085). Adjusting for diabetes, age and sex, frailty independently predicted low self-rated health (OR: 9.79 (5.85–16.36)), depression (9.82 (5.93–16.25)), and low QoL (8.52 (5.19–13.97)). Adjusting for frailty, age and sex, diabetes independently predicted low self-rated health (2.70 (1.63–4.47)). The age-sex adjusted mortality hazard ratio was highest for frailty with diabetes (4.67 (1.08–20.15)), followed by frailty without diabetes (2.86 (1.17–6.99)) and being non-frail with diabetes (1.76 (0.59–5.22)). Frailty independently predicts lower self-reported wellbeing and is associated with reduced survival, underpinning its role as an integral part of holistic diabetes care. Full article
(This article belongs to the Special Issue Diabetes Mellitus and Frailty)
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17 pages, 338 KiB  
Review
Chronic Lower Extremity Ischemia and Its Association with the Frailty Syndrome in Patients with Diabetes
by Grzegorz K. Jakubiak, Natalia Pawlas, Grzegorz Cieślar and Agata Stanek
Int. J. Environ. Res. Public Health 2020, 17(24), 9339; https://doi.org/10.3390/ijerph17249339 - 14 Dec 2020
Cited by 34 | Viewed by 6323
Abstract
Diabetes mellitus is an important risk factor for the development of cardiovascular diseases. Peripheral arterial disease affecting lower limb arteries is one of the clinical manifestations of atherosclerosis. The frailty syndrome (Frailty) is a problem associated with diminution of physiological reserves. The ankle-brachial [...] Read more.
Diabetes mellitus is an important risk factor for the development of cardiovascular diseases. Peripheral arterial disease affecting lower limb arteries is one of the clinical manifestations of atherosclerosis. The frailty syndrome (Frailty) is a problem associated with diminution of physiological reserves. The ankle-brachial index is a commonly used tool for diagnosing peripheral arterial disease (PAD). The usefulness of the ankle-brachial index (ABI) is limited in people with diabetes because of calcification of the middle layer of arteries. In this population, toe-brachial index should be measured. Frailty may be associated with worse prognosis for patients undergoing revascularization. Amputation may be an important factor leading to the development of Frailty. The risk of amputation and the prognosis after revascularization may be modified by some medications and blood glucose levels. The purpose of this paper is to review the literature about the association between PAD, especially in patients living with diabetes and Frailty. Full article
(This article belongs to the Special Issue Diabetes Mellitus and Frailty)
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