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Osteoporosis and Other Bone Tissue Disorders
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Osteoporosis and Other Bone Tissue Disorders

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (11 July 2023) | Viewed by 8194

Special Issue Editors

Dr. Agnieszka Matuszewska

E-Mail Website
Guest Editor
Department of Pharmacology, Wroclaw Medical University, 50-345 Wrocław, Poland
Interests: bones; osteoporosis; pharmacology; rheumatology
Dr. Benita Wiatrak

E-Mail Website
Guest Editor
Department of Pharmacology, Wroclaw Medical University, 50-368 Wroclaw, Poland
Interests: regenerative medicine; neurodegeneration; neuroregeneration; Alzheimer’s disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone tissue undergoes continuous remodeling processes. Osteoblasts, osteoclasts and osteocytes, among others, are involved in bone metabolism. The activity of these cells is regulated by many various factors. The imbalance between the enhancement of bone tissue formation and resorption processes can lead to many pathologies. One of them is osteoporosis.

Osteoporosis is a common health problem worldwide. It is characterized by a generalized low bone mass, disturbed bone microarchitecture, and an increased risk of bone fractures. Low-energy fractures occurring in its course may cause disability and even increased mortality.

In this Special Issue, we will focus on original and review papers on the pathogenesis and treatment of primary and secondary osteoporosis as well as other bone tissue disorders (including bone fractures and bone tissue regeneration).

Dr. Agnieszka Matuszewska
Dr. Benita Wiatrak
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoporosis
  • bones
  • osteoblasts
  • osteoclasts
  • vitamin D
  • adverse effects
  • fractures
  • bone tissue regeneration

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Published Papers (3 papers)

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Research

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12 pages, 1122 KiB  
Article
Spine Fragility Fracture Prediction Using TBS and BMD in Postmenopausal Women: A Bayesian Approach
by Claudio Ripamonti, Lucia Lisi, Jacopo Ciaffi, Angela Buffa, Renata Caudarella and Francesco Ursini
Int. J. Environ. Res. Public Health 2022, 19(21), 14315; https://doi.org/10.3390/ijerph192114315 - 2 Nov 2022
Cited by 1 | Viewed by 2081
Abstract
The trabecular bone score (TBS) estimates bone microarchitecture and can be used to evaluate the risk of osteoporotic fractures independently of bone mineral density (BMD). In this retrospective case-control study, we tested and compared the ability of TBS and lumbar spine BMD (LS-BMD) [...] Read more.
The trabecular bone score (TBS) estimates bone microarchitecture and can be used to evaluate the risk of osteoporotic fractures independently of bone mineral density (BMD). In this retrospective case-control study, we tested and compared the ability of TBS and lumbar spine BMD (LS-BMD) to predict vertebral fragility fractures. The inclusion criteria were female sex, age range 50–90 years, menopause, and clinical risk factors for osteoporosis. Patients with secondary osteoporosis were excluded. LS-BMD and TBS were measured at the L1–L4 vertebral level. The ability of the two diagnostic systems in predicting vertebral fragility fractures was assessed by combining LS-BMD and TBS according to the Bayesian “OR rule” (the diagnosis is negative only for those negative for both tests, and it is positive for those who were positive for at least one test) or to the “AND rule” (the diagnosis is positive only for those positive to both tests and is negative for those negative for at least one test). Of the 992 postmenopausal women included, 86 had a documented vertebral fragility fracture. At the cutoff value used in the present study, the TBS and LS-BMD showed a similar diagnostic ability to predict vertebral fragility fractures, having positive predictive values (PPV) of, respectively, 13.19% and 13.24%. Negative predictive values (NPV) were, respectively, 95.40% and 94.95%. Compared to that of each single diagnostic system, the “OR-rule” significantly increased the NPV to 97.89%, while no statistically significant differences were found by using the “AND-rule”. In conclusion, the present study highlights the possibility that combining LS-BMD and TBS could improve their predictive ability in diagnosing vertebral fragility fractures, and that there is a significant probability of absence of fractures in women who test negative to both diagnostic systems. Full article
(This article belongs to the Special Issue Osteoporosis and Other Bone Tissue Disorders)
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Review

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10 pages, 1362 KiB  
Review
Increased Risk of Fractures and Use of Proton Pump Inhibitors in Menopausal Women: A Systematic Review and Meta-Analysis
by Thuila Ferreira da Maia, Bruna Gafo de Camargo, Meire Ellen Pereira, Cláudia Sirlene de Oliveira and Izonete Cristina Guiloski
Int. J. Environ. Res. Public Health 2022, 19(20), 13501; https://doi.org/10.3390/ijerph192013501 - 19 Oct 2022
Cited by 9 | Viewed by 3163
Abstract
Proton pump inhibitors (PPIs) can directly interfere with osteoclastic function, induce hypergastrinemia, and inhibit calcium absorption, leading to reduced bone mineral density (BMD), a measure of bone metabolism that may be associated with the risk of fractures. The current study involves a systematic [...] Read more.
Proton pump inhibitors (PPIs) can directly interfere with osteoclastic function, induce hypergastrinemia, and inhibit calcium absorption, leading to reduced bone mineral density (BMD), a measure of bone metabolism that may be associated with the risk of fractures. The current study involves a systematic review and meta-analysis aimed at assessing the relationship between prolonged use of PPI drugs and fractures in menopausal women. A systematic search and meta-analysis were performed on PubMed, Scopus, and Science Direct databases according to PRISMA guidelines. Two independent reviewers analyzed the articles. The five articles found in the databases, which met the eligibility criteria, covered participants who were menopausal women aged between 56 and 78.5 years, using or not using a PPI for a minimum of 12 months. All studies showed an increase in the rate of fractures related to using PPIs, as an outcome. Prolonged use of PPIs in menopausal women can affect bone metabolism and cause fractures. However, other factors, such as the use of other classes of drugs, obesity, low weight, poor diet, replacement hormones, and comorbidities, should also be considered for assessing the risk of fractures. Full article
(This article belongs to the Special Issue Osteoporosis and Other Bone Tissue Disorders)
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Other

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8 pages, 942 KiB  
Case Report
Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature
by Katarzyna Wojciechowska-Durczynska, Arkadiusz Zygmunt, Marta Mikulak, Marta Ludwisiak and Andrzej Lewinski
Int. J. Environ. Res. Public Health 2022, 19(18), 11692; https://doi.org/10.3390/ijerph191811692 - 16 Sep 2022
Cited by 4 | Viewed by 2364
Abstract
Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-effects. We report a [...] Read more.
Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-effects. We report a 42-year-old female with GSD manifested in multifocal osteolysis and chronic chylothorax and ascites. The combined treatment with sirolimus and zoledronic acid due to its synergism of action was introduced. To our knowledge, this is the first Polish case report of adult patients with Gorham-Stout disease. Full article
(This article belongs to the Special Issue Osteoporosis and Other Bone Tissue Disorders)
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