Modern/Advanced Methods of Analysis of Xenobiotic Compounds—Xenobiotics Exposure, Human Health and Ecological Impacts

Dear Colleagues,

In their daily life, humans constantly encounter a huge amount of different substances, including xenobiotics, which are typically synthetic chemicals that are foreign to the body and/or to an ecological system. Xenobiotics can exert adverse effects on human health and increase the incidence of chronic diseases, including cancer, Parkinson’s, Alzheimer’s, multiple sclerosis, diabetes, cardiovascular, chronic kidney disease, and others. As a consequence, the development and validation of analytical methods for xenobiotics has become essential.

Further, in recent years, endocrine disrupting compounds (EDCs) have become the chemical group of special concern due to their ability to interfere with the hormonal system. Bisphenol A (BPA) and its analogs (such as bisphenol S (BPS), bisphenol F (BPF), bisphenol B (BPB), bisphenol C (BPC), bisphenol E (BPE), bisphenol M (BPM), bisphenol P (BPP), bisphenol Z (BPZ), bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol BP (BPBP), bisphenol FL (BPFL), dihydroxydiphenyl ether (DHDPE), and bisphenol A diglycidyl ether (BADGE)) have become the focus of strong concern because of their endocrine-disrupting effects and their widespread occurrence. As indicated in numerous research studies, bisphenols may be washed off the material surface and transferred to food or individual elements of the environment due to the interaction with food ingredients or the influence of external factors.

Moreover, many of these xenobiotics are characterized by lipophilicity; therefore, they are able to easily pass through biological membranes and penetrate living cells and thus be subject to bioaccumulation in various kinds of tissue and organs.

The most efficient approach to xenobiotic analysis involves the use of chromatographic methods. The following chromatographic methods are most frequently applied in environmental/biological samples and food analysis: high-performance liquid chromatography (HPLC), ultrahigh-performance liquid chromatography (UPLC), and gas chromatography (GC).

At present, chromatographic techniques coupled with modern detection techniques can find broad applications in the separation, identification, and quantification of xenobiotics (drugs and veterinary drugs, vitamins, dyes, mycotoxins, bisphenols, environmental bioindicators, allergens, and others) in different samples.

This Special Issue will present, in a structured manner, state-of-the-art information on the very important field of analytical methods such as high-performance chromatographic techniques coupled with modern detection techniques (e.g., DAD, FLD, mass spectrometry (MS) or tandem mass spectrometry (MS/MS)), biosensors, chips and others applied to analysis of xenobiotics (immuno- and bio- methods).

We are especially interested in research that has practical applications in understanding the nature and role played by xenobiotics in the development of human diseases, influence of xenobiotics on human health, preventive measures, prevention of intensification of disease, biomarkers of different diseases, xenobiotic exposure, the impact of xenobiotics on humans’ environment and their ecological impacts, environmental fate and transport of xenobiotics, and also green chemistry.

We welcome original research papers, critical reviews and short communications. There is no restriction on the length of the papers.

I warmly invite colleagues to submit their original contributions to this Special Issue, which will be of interest to a wide range of readers.

I would be delighted if you could respond and upload papers by 30 November 2022 (deadline). In cases of review articles, an additional brief (1–2 pages) description of the topic including a draft index is required. This preliminary step is essential to avoid overlapping of topics. The degree of novelty and the significance of the research will be scrutinized prior to the peer-reviewing process.

Topics of research of Special Issue:

• Xenobiotic exposure, human health, and ecological impacts;
• Analysis of xenobiotics in food, environmental, and biological samples;
• Analysis of xenobiotics in natural medicines and dietary supplements;
• Analysis of xenobiotics in other natural products and boosters;
• Analysis of xenobiotics in highly processed products and toys;
• Clinical, toxicological, and forensic analytics;
• Industrial analytics with synthesis.

Prof. Dr. Tomasz Tuzimski
Guest Editor

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• Xenobiotics (drugs and veterinary drugs, vitamins, dyes, mycotoxins, environmental bioindicators, allergens, bisphenols, pesticides, and others)
• Extraction techniques (QuEChERS/d-SPE, SPE, SPME, SBSE, HFLPME, DLLME, FUSLE, and others)
• Chromatographic methods (HPLC, UPLC, GC, GC x GC, and others)
• Detection techniques (DAD, FLD, MS, MS/MS, and others)
• Other analytical methods
• Environmental bioindicators
• Immuno- and bio-(analytical) methods, biosensors, chips and others applied to analysis of xenobiotics