Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 2724
Special Issue Editor
2. Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital–Research Institute, Lodz, Poland
Interests: short stature in children; growth hormone deficiency (GHD); primary and secondary insulin-like growth factor-1 (IGF-1) deficiency; GH therapy; long-acting GH (LAGH); transition phase in GHD patients from pediatric to adult services; disorders of GH-IGF-1 axis signaling pathways; GH secretagogues; ghrelin; sirtuins
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Special Issue Information
Dear Colleagues,
Treatment with recombinant human growth hormone (rhGH) in children and in adults with growth hormone deficiency (GHD) has been used for many years and has an established position when it comes to the principles of introducing therapy, its monitoring, dosage, safety, as well as the effectiveness and benefits of treatment. There are also known retesting principles during the process of transitioning children with GHD treated for growth promotion to the care of endocrinologists for adults who treat GHD patients to ensure the metabolic effects of GH.
Recently, however, GH treatment has become a hot topic again due to the emergence of long-acting GH (LAGH) preparations that can be used less frequently, e.g., once a week instead of the treatment used so far, which is once a day. The principles of LAGH treatment are still under analysis, and it is necessary to share the results of studies of individual research groups so that endocrinologists can gain experience in this field.
On the other hand, there are increasing amounts of reports on molecular mechanisms and their disorders involved in the transmission of signaling pathways in the GH-IGF-1 axis, both in the CNS, in the pituitary, in hepatocytes, or in the growth plate, which change and modify the secretion of GH and IGF-1.
New findings in this field allow us to define more precisely the type of mechanisms responsible for growth hormone deficiency, helping to identify further diagnostic and therapeutic areas in patients with GH and IGF-1 deficiency.
Therefore, researchers are invited to submit their reviews or original research on the discussed issues or other topics—related to various aspects of GHD—to this Special Issue of the International Journal of Molecular Sciences, titled “Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies” in order to create a collection of exciting papers that will be of interest to scientists and clinicians dealing with the treatment of GHD in children and adults.
Dr. Renata Stawerska
Guest Editor
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Keywords
- growth hormone (GH)
- growth hormone deficiency (GHD)
- growth hormone therapy
- long-acting growth hormone (LAGH)
- insulin-like growth factor-1 (IGF-1)
- growth hormone secretagogues
- signaling pathways of the GH-IGF-1 axis
- transition phase
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