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The Effect of Food-Derived Compounds on Brown Fat Cell Function
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The Effect of Food-Derived Compounds on Brown Fat Cell Function

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 2301

Special Issue Editor

Prof. Dr. Nobuyuki Takahashi

E-Mail Website
Guest Editor
Laboratory of Physiology and Metabolism, Department of Food Safety and Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan
Interests: nutrition; phytochemicals; lipids; nuclear receptors; lipid metabolisms; inflammation; insulin resistance; hyperlipidemia; adipocytes; hepatocytes; enterocytes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The biology of brown and beige adipocytes has advanced rapidly in recent years. These types of adipocytes have the ability to convert lipids accumulated by themselves and by white adipocytes into heat. This function of brown and beige adipocytes to consume accumulated lipids is expected to have various effects, including anti-obesity and anti-diabetic effects. However, their cell biological origin is still unknown. In addition, brown and beige adipocytes interact with various other cell types, including immune system cells such as macrophages, and the thermogenic function is regulated by these interactions. Furthermore, it has been shown that various food-derived components can exert anti-obesity effects by modulating the functions of these adipocytes. Therefore, this Special Issue welcomes a wide range of original and review articles focused on the latest developments in the molecular and cellular biology of various nutrients and compounds that regulate the function of brown and/or beige adipocytes.

Prof. Dr. Nobuyuki Takahashi
Guest Editor

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Keywords

  • brown adipocyte
  • beige adipocyte
  • nutrients
  • food-derived components
  • thermogenesis
  • energy homeostasis
  • inflammation
  • obesity
  • diabetes
  • insulin resistance
  • metabolic syndrome
  • adipokines
  • lipid and carbohydrate metabolism

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Published Papers (1 paper)

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Research

15 pages, 3596 KiB  
Article
The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and Cynara cardunculus L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice
by Saverio Nucera, Federica Scarano, Roberta Macrì, Rocco Mollace, Micaela Gliozzi, Cristina Carresi, Stefano Ruga, Maria Serra, Annamaria Tavernese, Rosamaria Caminiti, Annarita Coppoletta, Antonio Cardamone, Tiziana Montalcini, Arturo Pujia, Ernesto Palma, Carolina Muscoli, Francesco Barillà, Vincenzo Musolino and Vincenzo Mollace
Int. J. Mol. Sci. 2024, 25(1), 191; https://doi.org/10.3390/ijms25010191 - 22 Dec 2023
Cited by 5 | Viewed by 1801
Abstract
Obesity is one of the world’s most serious public health issues, with a high risk of developing a wide range of diseases. As a result, focusing on adipose tissue dysfunction may help to prevent the metabolic disturbances commonly associated with obesity. Nutraceutical supplementation [...] Read more.
Obesity is one of the world’s most serious public health issues, with a high risk of developing a wide range of diseases. As a result, focusing on adipose tissue dysfunction may help to prevent the metabolic disturbances commonly associated with obesity. Nutraceutical supplementation may be a crucial strategy for improving WAT inflammation and obesity and accelerating the browning process. The aim of this study was to perform a preclinical “proof of concept” study on Bergacyn®, an innovative formulation originating from a combination of bergamot polyphenolic fraction (BPF) and Cynara cardunculus (CyC), for the treatment of adipose tissue dysfunction. In particular, Bergacyn® supplementation in WD/SW-fed mice at doses of 50 mg/kg given orally for 12 weeks, was able to reduce body weight and total fat mass in the WD/SW mice, in association with an improvement in plasma biochemical parameters, including glycemia, total cholesterol, and LDL levels. In addition, a significant reduction in serum ALT levels was highlighted. The decreased WAT levels corresponded to an increased weight of BAT tissue, which was associated with a downregulation of PPARγ as compared to the vehicle group. Bergacyn® was able to restore PPARγ levels and prevent NF-kB overexpression in the WAT of mice fed a WD/SW diet, suggesting an improved oxidative metabolism and inflammatory status. These results were associated with a significant potentiation of the total antioxidant status in WD/SW mice. Finally, our data show, for the first time, that Bergacyn® supplementation may be a valuable approach to counteract adipose tissue dysfunction and obesity-associated effects on cardiometabolic risk. Full article
(This article belongs to the Special Issue The Effect of Food-Derived Compounds on Brown Fat Cell Function)
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