Histone Chaperones and Chromatin Remodelers: Mechanisms of Action and Regulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 2224
Special Issue Editor
2. Fox Chase Cancer Center, Philadelphia, PA 19111-2497, USA
Interests: mechanisms of transcription and replication in chromatin; mechanisms of histone chaperone action in chromatin
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chromatin is a highly dynamic structure that is extensively and reversibly modified by various factors, including enzymes running DNA transactions, chromatin remodelers, histone and DNA modifications, and other factors to ensure the development and survival of a cell. Chromatin remodelers participate in nearly every DNA transaction in the cell nuclei, including DNA replication, transcription, and repair. Chromatin remodelers include histone chaperones, histone-modifying enzymes and ATP-dependent chromatin remodeling complexes. Chromatin remodelers facilitate various transitions in chromatin structure, including nucleosome sliding, assembly, and disassembly, changes in the nucleosome structure, and histone variant exchange. They also participate in histone transport, deposition, eviction, and storage. However, their mechanisms of action, interacting partners, and their roles in the regulation of cellular metabolism and development of human diseases remain to be further established.
We invite researchers to present their studies of the mechanisms of action and regulation of histone chaperones and chromatin remodelers and their complexes with proteins and other biological molecules, and to discuss their data and opinions on the pages of the International Journal of Molecular Sciences.
Prof. Dr. Vasily M. Studitsky
Guest Editor
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Keywords
- histone chaperones
- chromatin remodelers
- chromatin
- mechanism
- structure
- regulation
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