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Advances in Pathogenesis, Molecular Mechanisms, and Therapeutic Strategies for Neurodegenerative Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 1501

Special Issue Editor

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS), pose a significant and escalating public health challenge globally. The complexity of these conditions necessitates a thorough understanding of their pathogenesis and molecular mechanisms to develop effective therapeutic strategies. Recent advancements in biomedical research have significantly deepened our understandings of the pathogenesis of these diseases, revealing intricate molecular pathways and identifying novel therapeutic targets.

This Special Issue seeks to highlight cutting-edge research and comprehensive reviews that explore the latest developments in the pathogenesis, molecular mechanisms, and therapeutic strategies of neurodegenerative diseases. We invite submissions that delve into the multifaceted interplay of genetic, environmental, and lifestyle factors that contribute to these disorders. Key areas of interest include the roles of protein misfolding and aggregation, mitochondrial dysfunction, oxidative stress, neuroinflammation, and impaired protein quality control systems in disease progression.

In addition to studies elucidating disease mechanisms, we encourage submissions focusing on innovative therapeutic approaches. This includes gene therapy, RNA-based therapies, small molecule inhibitors, and immunotherapies targeting pathogenic proteins such as amyloid β, tau, and α-synuclein. We are particularly interested in research exploring the potential of stem cell-based regenerative therapies and neuroprotective strategies aimed at mitigating oxidative stress and mitochondrial dysfunction.

By bringing together diverse perspectives and cutting-edge research, this Special Issue aims to foster a deeper understanding of neurodegenerative diseases and pave the way for more effective, personalized therapeutic interventions. We look forward to your contributions that will advance the field and improve patient outcomes and quality of life.

Dr. Abdullah Sheikh
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • neurodegeneration
  • molecular pathways
  • protein aggregation
  • gene therapy
  • neuroprotection

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Published Papers (1 paper)

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Research

17 pages, 2126 KiB  
Article
The Impact of High-Dose Fish Oil Supplementation on Mfsd2a, Aqp4, and Amyloid-β Expression in Retinal Blood Vessels of 5xFAD Alzheimer’s Mouse Model
by Irena Jovanovic Macura, Desanka Milanovic, Vesna Tesic, Tamara Major, Milka Perovic, Miroslav Adzic and Sanja Ivkovic
Int. J. Mol. Sci. 2024, 25(17), 9400; https://doi.org/10.3390/ijms25179400 - 29 Aug 2024
Viewed by 1285
Abstract
In patients with Alzheimer’s disease (AD) and in animal models, the increased accumulation of amyloid β (Aβ) in retinal blood vessels strongly correlates with brain amyloid deposits and cognitive decline. The accumulation of Aβ in blood vessels may result from impaired transcytosis and [...] Read more.
In patients with Alzheimer’s disease (AD) and in animal models, the increased accumulation of amyloid β (Aβ) in retinal blood vessels strongly correlates with brain amyloid deposits and cognitive decline. The accumulation of Aβ in blood vessels may result from impaired transcytosis and a dysfunctional ocular glymphatic system in AD. High-dose fish oil (FO) supplementation has been shown to significantly change the expression of major facilitator superfamily domain-containing protein 2a (Mfsd2a), a key regulator of transcytosis, and Aquaporin 4 (Aqp4), an essential component of the glymphatic system in the retinas of WT mice. We examined the expression of Mfsd2a and Aqp4 in the retinas of 4-month-old 5xFAD female mice supplemented with high-dose FO for three weeks. There was a significant increase in Mfsd2a expression in 5xFAD retinas supplemented with FO compared to control 5xFAD mice. Additionally, the increase in Aqp4 expression observed in 4-month-old 5xFAD retinas, indicative of an impaired glymphatic system, was significantly decreased. Simultaneously, Aβ accumulation in 5xFAD retinal blood vessels was reduced following FO supplementation. These findings suggest that high-dose FO supplementation could serve as an adjunct in developing new treatments aimed at improving the regulation of transcytosis or the function of the glymphatic system in the AD retina. Full article
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