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Key Advances in Cardiovascular Diseases
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Key Advances in Cardiovascular Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (10 May 2024) | Viewed by 8037

Special Issue Editor

Dr. Chayakrit Krittanawong

E-Mail Website
Guest Editor
NYU Grossman School of Medicine, New York, NY 10016, USA
Interests: AI; precision medicine; integrative omics; bioinformatics; big data analytics; multi-omics; digital health; wearable technology; preventive medicine; cardiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to provide a summary of the molecular basis of and key advances in clinical cardiology and particularly preventive and interventional cardiology as well as future directions and should be of interest to both practicing clinicians and scientists.

First, this Special Issue summarizes the pillars of preventive cardiology and the molecular mechanisms associated with them, which include the primary and secondary prevention of cardiovascular diseases such as smoking cessation or avoidance, a prudent diet, weight management, regular exercise, stress management, and regular blood sugar, cholesterol, and pressure checks.

Second, the development of stem cell biology has enabled cell-based therapy as a promising approach to promote the repair of injured tissue and replenish new and functional cells.

This Special Issue will also highlight reviews or recent advances in existing technology and the development of new technology in all interventional subspecialities including coronary, peripheral, structural, and congenital heart disease (e.g., intracoronary laser therapy, drug-coated balloon, ultra-high-pressure balloon angioplasty).

The more important aim is to provide researchers with an opportunity to publish both original research and review articles related to recent advances in coronary artery disease and heart failure, pre-clinical or pure model submissions detailing biomolecular experiments are welcome.

Dr. Chayakrit Krittanawong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • preventive cardiology
  • interventional cardiology

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Published Papers (2 papers)

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Review

24 pages, 1389 KiB  
Review
The Role of Furin and Its Therapeutic Potential in Cardiovascular Disease Risk
by Hannah Fry, Mohsen Mazidi, Christiana Kartsonaki, Robert Clarke, Robin G. Walters, Zhengming Chen and Iona Y. Millwood
Int. J. Mol. Sci. 2024, 25(17), 9237; https://doi.org/10.3390/ijms25179237 - 26 Aug 2024
Viewed by 1453
Abstract
Furin is an important proteolytic enzyme, converting several proteins from inactive precursors to their active forms. Recently, proteo-genomic analyses in European and East Asian populations suggested a causal association of furin with ischaemic heart disease, and there is growing interest in its role [...] Read more.
Furin is an important proteolytic enzyme, converting several proteins from inactive precursors to their active forms. Recently, proteo-genomic analyses in European and East Asian populations suggested a causal association of furin with ischaemic heart disease, and there is growing interest in its role in cardiovascular disease (CVD) aetiology. In this narrative review, we present a critical appraisal of evidence from population studies to assess furin’s role in CVD risk and potential as a drug target for CVD. Whilst most observational studies report positive associations between furin expression and CVD risk, some studies report opposing effects, which may reflect the complex biological roles of furin and its substrates. Genetic variation in FURIN is also associated with CVD and its risk factors. We found no evidence of current clinical development of furin as a drug target for CVD, although several phase 1 and 2 clinical trials of furin inhibitors as a type of cancer immunotherapy have been completed. The growing field of proteo-genomics in large-scale population studies may inform the future development of furin and other potential drug targets to improve the treatment and prevention of CVD. Full article
(This article belongs to the Special Issue Key Advances in Cardiovascular Diseases)
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12 pages, 856 KiB  
Review
Celiac Disease and the Risk of Cardiovascular Diseases
by Yichen Wang, Bing Chen, Edward J. Ciaccio, Hani Jneid, Salim S. Virani, Carl J. Lavie, Jessica Lebovits, Peter H. R. Green and Chayakrit Krittanawong
Int. J. Mol. Sci. 2023, 24(12), 9974; https://doi.org/10.3390/ijms24129974 - 9 Jun 2023
Cited by 15 | Viewed by 5967
Abstract
Celiac disease (CD) is a chronic autoimmune disorder that affects the small intestine in genetically predisposed individuals. Previous studies have investigated the potential link between CD and cardiovascular disease (CVD); however, the findings have been inconsistent. We aimed to provide an updated review [...] Read more.
Celiac disease (CD) is a chronic autoimmune disorder that affects the small intestine in genetically predisposed individuals. Previous studies have investigated the potential link between CD and cardiovascular disease (CVD); however, the findings have been inconsistent. We aimed to provide an updated review of the literature on the association between CD and CVD. PubMed was searched from inception to January 2023 using keywords including CD, cardiovascular disease, coronary artery disease, cardiac arrhythmia, heart failure, cardiomyopathy, and myocarditis. We summarized the results of the studies, including meta-analyses and original investigations, and presented them according to the different forms of CVD. Meta-analyses published in 2015 provided mixed results regarding the relationship between CD and CVD. However, subsequent original investigations have shed new light on this association. Recent studies indicate that individuals with CD are at a higher risk of developing overall CVD, including an increased risk of myocardial infarction and atrial fibrillation. However, the link between CD and stroke is less established. Further research is needed to determine the link between CD and other cardiac arrhythmias, such as ventricular arrhythmia. Moreover, the relationship between CD and cardiomyopathy or heart failure, as well as myopericarditis, remains ambiguous. CD patients have a lower prevalence of traditional cardiac risk factors, such as smoking, hypertension, hyperlipidemia, and obesity. Therefore, it is important to discover strategies to identify patients at risk and reduce the risk of CVD in CD populations. Lastly, it is unclear whether adherence to a gluten-free diet can diminish or increase the risk of CVD among individuals with CD, necessitating further research in this area. To fully comprehend the correlation between CD and CVD and to determine the optimal prevention strategies for CVD in individuals with CD, additional research is necessary. Full article
(This article belongs to the Special Issue Key Advances in Cardiovascular Diseases)
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