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Molecular Advances in Parvovirus

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1488

Special Issue Editor


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Guest Editor
Stem Cells and Therapeutic Applications Laboratory (LCSAT), UMR-1184, IMVA-HB (Immunology of Viral, Autoimmune, Hematopoietic and Bacteriological Diseases), IDMIT (Infectious Diseases Models for Innovative Therapies) Center, CEA, INSERM, Paris-Saclay University, F-92265 Fontenay-aux-Roses, France
Interests: parvovirus B19; erythroid tropism; transcription factors; signaling pathways; erythropoiesis

Special Issue Information

Dear Colleagues,

The evolution of research on the molecular mechanisms of parvoviruses represents a fascinating journey in our understanding of the interactions between these viruses and their hosts. From the initial discoveries of parvoviruses to the present day, there have been technological advancements and breakthroughs in molecular virology, which have significantly enriched our knowledge.

Early studies on parvoviruses primarily focused on their structure and classification. Over time, research shifted towards understanding the molecular mechanisms underlying parvovirus infection. More recently, advances in sequencing and genomics technologies have revolutionized our ability to study parvoviruses at the molecular level. Concurrently, the use of cellular and animal models has characterized the molecular mechanisms of parvovirus pathogenesis. Overall, the evolution of research on the molecular mechanisms of parvoviruses reflects the ongoing commitment of researchers to understand these complex pathogens. As new technologies emerge and new scientific questions arise, research on parvoviruses continues to advance, offering new perspectives on viral biology and opening new avenues for the development of antiviral therapies and vaccines.

This Special Issue invites original research and review articles, covering a diverse array of topics. Research areas of interest encompass an intricate interplay between cells and parvoviruses during viral replication, gene expression, latent or lytic infection, and viral structural protein and enzyme dynamics. Additionally, investigations into virus assembly, cell signaling pathways, post-translational modifications, and host factors are encouraged. Contributions exploring virus immune evasion, host immune responses, viral tumorigenesis or disease mechanisms, as well as developments in antiviral medications, vaccines, animal models, and gene therapy, are highly valued. Be inspired by this fascinating topic on the molecular mechanisms of parvoviruses.

Dr. Zahra Kadri
Guest Editor

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Keywords

  • parvovirus structure
  • parvovirus replication
  • parvovirus proteome
  • cell signaling pathways
  • transcription, translation and post-translational modification
  • host restriction factor
  • host/parvovirus interaction
  • recombinant virus and VLP
  • immune evasion and/or activation
  • host tropism (cell type and species)
  • new experimental models and approaches

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Published Papers (1 paper)

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Research

24 pages, 5330 KiB  
Article
Molecular Epidemiology and Phyloevolutionary Analysis of Porcine Parvoviruses (PPV1 through PPV7) Detected in Replacement Gilts from Colombia
by Diana S. Vargas-Bermudez, Bruno Aschidamini Prandi, Ueric José Borges de Souza, Ricardo Durães-Carvalho, José Darío Mogollón, Fabrício Souza Campos, Paulo Michel Roehe and Jairo Jaime
Int. J. Mol. Sci. 2024, 25(19), 10354; https://doi.org/10.3390/ijms251910354 - 26 Sep 2024
Viewed by 1262
Abstract
Eight porcine parvovirus (PPV) species, designated as PPV1 through PPV8, have been identified in swine. Despite their similarities, knowledge about their distribution and genetic differences remains limited, resulting in a gap in the genetic classification of these viruses. In this study, we conducted [...] Read more.
Eight porcine parvovirus (PPV) species, designated as PPV1 through PPV8, have been identified in swine. Despite their similarities, knowledge about their distribution and genetic differences remains limited, resulting in a gap in the genetic classification of these viruses. In this study, we conducted a comprehensive analysis using PPV1 to PPV7 genome sequences from Colombia and others available in the GenBank database to propose a classification scheme for all PPVs. Sera from 234 gilts aged 180 to 200 days were collected from 40 herds in Colombia. Individual detection of each PPV (PPV1 through PPV7) was performed using end-point PCR. Complete nucleotide (nt) sequencing was performed on the PPV1 viral protein (VP), and near-complete genome (NCG) sequencing was carried out for novel porcine parvoviruses (nPPVs) (PPV2 through PPV7). Phylogenetic analyses were conducted by comparing PPV1-VP sequences to 94 available sequences and nPPVs with 565 NCG, 846 nPPV-VP, and 667 nPPV–nonstructural protein (NS) sequences. Bayesian phylogenetic analysis was used to estimate substitution rates and the time to the most recent common ancestor for each PPV. The highest prevalence was detected for PPV3 (40.1%), followed by PPV5 (20.5%), PPV6 (17%), PPV1 (14.5%), PPV2 (9.8%), PPV4 (4.2%), and PPV7 (1.3%). Notably, all tested sera were negative for PPV8 genomes. An analysis of the PPV1-VP sequences revealed two main clades (PPV1-I and PPV1-II), with the sequences recovered in this study grouped in the PPV1-II clade. Comparative analysis showed significant genetic distances for PPV2 to PPV7 at the NCG (>6.5%), NS (>6.3%), and VP (>7.5%) regions, particularly when compared to equivalent regions of PPV genomes recovered worldwide. This study highlights the endemic circulation of nPPVs in Colombian pig herds, specifically among gilts. Additionally, it contributes to the phylogenetic classification and evolutionary studies of these viruses. The proposed method aims to categorize and divide subtypes based on current knowledge and the genomes available in databanks. Full article
(This article belongs to the Special Issue Molecular Advances in Parvovirus)
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