Molecular Research on Sjögren’s Syndrome: From Pathogenesis to Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 630
Special Issue Editor
Interests: inflammatory rheumatic diseases (especially Sjögren's syndrome and systemic sclerosis); intracellular signaling pathways; micro- and macrovascular involvement in inflammatory rheumatic diseases; nailfold capillaroscopy in inflammatory rheumatic diseases; atherosclerosis associated with inflammatory rheumatic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sjögren’s syndrome (SS) represents a systemic rheumatic disorder with autoimmune pathogenesis characterized by the sicca complex (xerostomia and xerophthalmia). It can be primary SS (pSS), appearing alone, or secondary SS (sSS), associated with another autoimmune disease (especially systemic lupus erythematosus and rheumatoid arthritis). The interaction between the genetic predisposition and the intervention of some environmental factors activates the immune system (innate and adaptive immunity), leading to chronic inflammation and the destruction of glandular parenchyma, which is responsible for the manifestations of this condition. The molecular mechanisms involved in salivary gland dysfunction, extraglandular manifestations and the development of complications have not been completely known until now. The identification of the molecular mechanisms that underlie the clinical manifestations and complications of this disorder may contribute to the discovery of novel therapeutic strategies. In this Special Issue titled “Molecular Research on Sjögren's Syndrome, from Pathogenesis to Therapy”, we aim to publish articles related to molecular mechanisms involved in the appearance of this disorder and its complications. Articles related to the involvement of T and B cells, macrophage, dendritic cells, salivary gland epithelial cells, inflammatory mediators (cytokines, chemokines, antibodies), and intracellular signaling pathways (IFN, TLR, BAFF/BAFF-R, PI3K/Akt/mTOR) are invited. By identifying the molecular mechanisms underlying this disorder, new biomarkers, diagnostic tools, and treatment options can be found.
Dr. Alexandru Emil Caraba
Guest Editor
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Keywords
- Sjögren's syndrome
- salivary glands
- lacrimal glands
- T and B cells
- macrophage, dendritic cells, salivary gland epithelial cells
- inflammatory mediators (cytokines, chemokines, antibodies)
- intracellular signaling pathways (IFN, TLR, BAFF/BAFF-R, PI3K/Akt/mTOR)
- atherosclerosis
- lymphoma
- novel therapeutic strategies
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