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Recent Advances in Molecular Materials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 4554

Special Issue Editor

Dr. Jiangmin Jiang

E-Mail Website
Guest Editor
School of Materials Science and Physics, China University of Mining and Technology, Xuzhou, China
Interests: development and application of new materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue highlights the growing interest in recent advances in molecular materials and biomedicine. Biomedicine is an important engineering field related to improving the level of medical diagnosis and human health, and is the base of academic research and innovation of biomedical information, gene chip, nanotechnology, new materials, and other technologies. With the development of materials science and molecular technology, various molecular materials have received more and more attention in biomedical fields such as biosensing, medical imaging, tissue engineering, regenerative medicine, and targeted drug delivery, including quantum dots, carbon nanotubes, protein nanostructures, gold nanoshells, various inorganic/organic materials, liposomes, and molecular structure composite materials. Although molecular materials have made great progress in the field of biomedicine, further in-depth and comprehensive exploration is still needed, such as natural biological materials (such as cells, viruses, exosomes, protein molecules and other organisms; or shells, coral, bones, insect wings and other natural mineralized materials), a variety of synthetic molecular materials and so on. We welcome the submission of original article, review, and communication.

This Special issue is supervised by Dr. Shijing Wang, who is assisted by our Topical Advisory Panel Member <[email protected]> (Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China).

Dr. Jiangmin Jiang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biomaterials
  • structural/functional/sensor materials
  • self-assembly/macromolecular materials
  • optoelectronic/magnetic materials
  • soft materials
  • molecular diagnostic techniques/methods
  • potential molecular targets
  • functional biological macromolecules
  • biotechnology macromolecules

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

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Research

37 pages, 3031 KiB  
Article
Structure and Properties of Poly(Ethylene-Co-Vinyl Acetate) Nanocomposites with Dual-Functionalized Dolomite Nanoparticles
by Asfa Amalia Ahmad Fauzi, Azlin Fazlina Osman, Eid M. Alosime, Khairul Anwar Abdul Halim and Mohd Aidil Adhha Abdullah
Int. J. Mol. Sci. 2024, 25(23), 12519; https://doi.org/10.3390/ijms252312519 - 21 Nov 2024
Viewed by 218
Abstract
Poly(ethylene-co-vinyl acetate) (PEVAc) is a copolymer that consists of non-polar polyethylene (PE) and a polar polyvinyl acetate (PVAc) monomer. PEVAc has high elasticity and is resilient, making it suitable for a variety of applications. However, the tensile strength of this copolymer needs to [...] Read more.
Poly(ethylene-co-vinyl acetate) (PEVAc) is a copolymer that consists of non-polar polyethylene (PE) and a polar polyvinyl acetate (PVAc) monomer. PEVAc has high elasticity and is resilient, making it suitable for a variety of applications. However, the tensile strength of this copolymer needs to be improved for specific applications that require enough strength to tolerate high external tension or stress. This study proposed the use of dual-functionalized dolomite nanoparticles (DF-DNPs) composed of polar and non-polar nano-dolomite (P-DNPs and NP-DNPs) as nanofillers to reinforce the PEVAc. PEVAc/DF-DNP film appears to have a more homogeneous mixture, which is better for forming an optimal nanocomposite material. It also exhibits the highest tensile strength (10.48 MPa), elongation at break (1175.73%), and tensile toughness (62.12 MPa), which are higher by increments of 46.8%, 9.4%, and 20.3%, respectively, as compared to the neat PEVAc. The result proved that using DF-DNPs as a nanofiller can improve the strength of PEVAc while maintaining its flexibility to avoid brittleness of the nanocomposite film. Furthermore, its thermal characteristics were also successfully enhanced. A biostability assessment showed that the use of DF-DNPs as nanofiller caused the PEVAc copolymer to achieve the best water resistance, as it only exhibited a 2.63% weight increase, the lowest reduction in tensile properties among the studied fillers, and the best retention in surface degradation upon 3-month exposure to the in vitro environment. These findings indicate that the DF-DNPs help in developing a homogeneous nanocomposite by interacting with PE and PVAc. Full article
(This article belongs to the Special Issue Recent Advances in Molecular Materials)
12 pages, 6148 KiB  
Article
Preparation of Conductive Cellulose Coated with Conductive Polymer and Its Application in the Detection of pH and Characteristic Substances in Sweat
by Yujia Wu, Defa Hou, Yunwu Zheng, Xu Lin, Fulin Yang, Can Liu and Hao Sun
Int. J. Mol. Sci. 2024, 25(12), 6393; https://doi.org/10.3390/ijms25126393 - 10 Jun 2024
Viewed by 993
Abstract
Rich biological information in sweat provides great potential for health monitoring and management. However, due to the complexity of sweat, the development of environmentally friendly green electronic products is of great significance to the construction of ecological civilization. This study utilized a simple [...] Read more.
Rich biological information in sweat provides great potential for health monitoring and management. However, due to the complexity of sweat, the development of environmentally friendly green electronic products is of great significance to the construction of ecological civilization. This study utilized a simple combination of polystyrene sulfonate sodium (PSS) and filter paper (FP) to prepare cellulose materials coated with conductive polymers, developing an electrochemical sensor based on the modified materials. The mechanical and electrochemical properties of the fabricated PSS/FP membrane were optimized by adjusting the feeding dosage of PSS. The realized PSS/FP composite containing 7% PSS displayed good conductivity (9.1 × 10−2 S/m), reducing electric resistance by 99.2% compared with the original FP membrane (6.7 × 10−4 S/m). The stable current of the membrane in simulated sweat under different pH environments is highly correlated with the pH values. Additionally, when the membrane is exposed to simulated sweat with varying ion concentrations, the current signal changes in real time with the concentration variations. The response time averages around 0.3 s. Full article
(This article belongs to the Special Issue Recent Advances in Molecular Materials)
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14 pages, 2096 KiB  
Article
Profiling of Early Immune Responses to Vaccination Using THP-1-Derived Dendritic Cells
by Lei Ye, Ping Li, Mingzhe Wang, Feng Wu, Sanyang Han and Lan Ma
Int. J. Mol. Sci. 2024, 25(10), 5509; https://doi.org/10.3390/ijms25105509 - 18 May 2024
Cited by 1 | Viewed by 1451
Abstract
The COVID-19 pandemic has made assessing vaccine efficacy more challenging. Besides neutralizing antibody assays, systems vaccinology studies use omics technology to reveal immune response mechanisms and identify gene signatures in human peripheral blood mononuclear cells (PBMCs). However, due to their low proportion in [...] Read more.
The COVID-19 pandemic has made assessing vaccine efficacy more challenging. Besides neutralizing antibody assays, systems vaccinology studies use omics technology to reveal immune response mechanisms and identify gene signatures in human peripheral blood mononuclear cells (PBMCs). However, due to their low proportion in PBMCs, profiling the immune response signatures of dendritic cells (DCs) is difficult. Here, we develop a predictive model for evaluating early immune responses in dendritic cells. We establish a THP-1-derived dendritic cell (TDDC) model and stimulate their maturation in vitro with an optimal dose of attenuated yellow fever 17D (YF-17D). Transcriptomic analysis reveals that type I interferon (IFN-I)-induced immunity plays a key role in dendritic cells. IFN-I regulatory biomarkers (IRF7, SIGLEC1) and IFN-I-inducible biomarkers (IFI27, IFI44, IFIT1, IFIT3, ISG15, MX1, OAS2, OAS3) are identified and validated in vitro and in vivo. Furthermore, we apply this TDDC approach to various types of vaccines, providing novel insights into their early immune response signatures and their heterogeneity in vaccine recipients. Our findings suggest that a standardizable TDDC model is a promising predictive approach to assessing early immunity in DCs. Further research into vaccine efficacy assessment approaches on various types of immune cells could lead to a systemic regimen for vaccine development in the future. Full article
(This article belongs to the Special Issue Recent Advances in Molecular Materials)
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12 pages, 5176 KiB  
Article
Development of Detection Antibody Targeting the Linear Epitope in SARS-CoV-2 Nucleocapsid Protein with Ultra-High Sensitivity
by Feng Wu, Yike Jiang, Hongtian Yang and Lan Ma
Int. J. Mol. Sci. 2024, 25(8), 4436; https://doi.org/10.3390/ijms25084436 - 18 Apr 2024
Cited by 2 | Viewed by 1103
Abstract
The COVID-19 pandemic caused by SARS-CoV-2 highlighted the importance of reliable detection methods for disease control and surveillance. Optimizing detection antibodies by rational screening antigens would improve the sensitivity and specificity of antibody-based detection methods such as colloidal gold immunochromatography. In this study, [...] Read more.
The COVID-19 pandemic caused by SARS-CoV-2 highlighted the importance of reliable detection methods for disease control and surveillance. Optimizing detection antibodies by rational screening antigens would improve the sensitivity and specificity of antibody-based detection methods such as colloidal gold immunochromatography. In this study, we screened three peptide antigens with conserved sequences in the N protein of SARS-CoV-2 using bioinformatical and structural biological analyses. Antibodies that specifically recognize these peptides were prepared. The epitope of the peptide that had the highest binding affinity with its antibody was located on the surface of the N protein, which was favorable for antibody binding. Using the optimal antibody that can recognize this epitope, we developed colloidal gold immunochromatography, which can detect the N protein at 10 pg/mL. Importantly, this antibody could effectively recognize both the natural peptide antigen and mutated peptide antigen in the N protein, showing the feasibility of being applied in the large-scale population testing of SARS-CoV-2. Our study provides a platform with reference significance for the rational screening of detection antibodies with high sensitivity, specificity, and reliability for SARS-CoV-2 and other pathogens. Full article
(This article belongs to the Special Issue Recent Advances in Molecular Materials)
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