Myeloid-Derived Suppressor Cells in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 2073
Special Issue Editor
Special Issue Information
Dear Colleagues,
During their development and progression, tumors acquire specific properties that enable them to evade immune responses, creating conditions that suppress the antitumor immune response. Over the past decade, the generation and expansion of myeloid-derived suppressor cells (MDSCs) have emerged as a critical mechanism for cancer-induced immunosuppression. MDSCs are a heterogeneous group of immature myeloid cells that induce potent immunosuppression by producing various immune-inhibitory cytokines, enzymes, and chemically reactive molecules containing oxygen and nitrogen. Extensive clinical and experimental studies have shown that MDSC levels correlate with tumor burden, stage, and short-term survival. Consequently, MDSCs are now considered major challenges in cancer immunotherapies, and targeting them could be a highly valuable strategy to enhance the effectiveness of chemotherapeutic and immunotherapeutic approaches.
Experimental tumor models have contributed significantly to a better understanding of the underlying mechanisms involved in the development, homing, and functionality of MDSCs in tumors. They have also been instrumental in testing anti-MDSC therapies in vivo. However, the precise role of tumor cells, host cells, and microbiota in generating and expanding these cells remains elusive.
Furthermore, information obtained from experimental tumors cannot be directly applied to patients with cancer because of the substantial heterogeneity of MDSCs across different cancer types. Additionally, the lack of specific biomarkers and a straightforward separation/characterization technique for human MDSCs has resulted in limited knowledge about tumor-infiltrating MDSCs in human cancers and their roles in tumor progression and metastasis.
This Special Issue, entitled "Myeloid-Derived Suppressor Cells in Cancer" aims to consider papers for publication that address the aforementioned challenges related to MDSCs in different cancers, as well as those exploring the biology of MDSCs and novel modalities that target these cells in cancer.
Dr. Manuchehr Abedi-Valugerdi
Guest Editor
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Keywords
- cancer
- tumor
- myeloid-derived suppressor cells (MDSCs)
- immunosuppression
- immune escape
- myelopoiesis
- G-MDSCs
- M-MDSCs
- biomarkers
- tumor models
- extramedullary hematopoiesis
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