Mechanisms of Vascular Calcification 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3942
Special Issue Editors
Interests: vascular calcification; vascular smooth muscle cells; phosphate homeostasis; chronic kidney disease; vascular stiffness and fibrosis; cardiac remodeling
Special Issues, Collections and Topics in MDPI journals
Interests: vascular calcification; vascular senescence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ectopic calcification in cardiovascular tissue is a common phenomenon closely connected with cardiovascular mortality. However, the underlying mechanisms are complex and currently no widely available treatment is available to prevent the development and progression of ectopic calcifications.
Under physiological conditions, the ectopic deposition of calcium and phosphate is regulated by a fine-tuned system of local and circulating calcification inhibitors. Various pathological conditions can shift this balance, thereby resulting in “mineral stress”, ultimately leading to ectopic calcifications as a consequence of active mineralization processes. Various stimuli may induce the reprogramming of vascular smooth muscle cells, fibroblast-like cells, endothelial cells, and other cell types into cells with pro-calcific properties. These “transdifferentiated” cells can augment ectopic mineralization using various mechanisms such as the release of calcifying vesicles, an impairment of calcification inhibitors or matrix remodelling. Inflammatory mediators are recognized for activating intracellular pathways, which promote calcific processes. However, the complex and diverse mechanisms participating in various forms of ectopic calcification are still not completely understood. Advancing research in this field is needed to establish new therapeutic concepts.
After a successful first Special Issue of IJMS, we cordially invite you again to submit research works on “Mechanisms of Cardiovascular Calcification". This call is aimed to encourage submissions of focused reviews and original work of relevant pre-clinical and clinical studies regarding the development, progression and consequences of ectopic cardiovascular calcifications as well as novel methodological approaches.
Prof. Dr. Jakob Voelkl
Dr. Mirjam Schuchardt
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- vascular calcification
- valvular calcification
- vascular smooth muscle cells
- endothelial cells
- procalcific signaling molecules
- calcification inhibitors
- phosphate/calcium homeostasis
- pro-/anticalcific signaling pathways
- regulation of calcium–phosphate deposition
- consequences of cardiovascular calcification
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
