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Molecular Insights into Reproductive Biology and Related Diseases

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Guest Editor
Department of Animal Production, Veterinary Faculty, Complutense University of Madrid, 28040 Madrid, Spain
Interests: animal reproduction; spermatology; molecular reproduction; farm animals; wildlife

Special Issue Information

Dear Colleagues,

Reproduction is determined by a series of cellular and molecular events to guarantee a spermatozoon’s ability to reach and fertilize the oocyte. Fine-tune regulation at the molecular level of sperm motility, sperm capacitation, or oocyte maturation allows fertilization. Once the zygote is formed, the success of embryo development is regulated by complex molecular mechanisms. However, misregulation at the molecular level can lead to reproductive diseases such as infertility or loss of embryos. Thus, it is crucial to understand the molecular regulation of both male and female gametes, as well as embryo development, to deepen our knowledge in reproductive biology and its related diseases.

The goal of this Special Issue is to cover new advances in molecular reproduction and reproductive diseases in domestic, laboratory, and wild animals, as well as in human research. All formats of scientific work (original articles, reviews, and short communications) will be accepted in this Special Issue.

Dr. Alejandro Vicente-Carrillo
Guest Editor

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Keywords

  • spermatozoa
  • oocyte
  • molecular reproduction
  • infertility

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Published Papers (1 paper)

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Review

19 pages, 2328 KiB  
Review
The Intricate Functional Networks of Pre-mRNA Alternative Splicing in Mammalian Spermatogenesis
by Nan Jiang, Yi Li, Lisha Yin, Shuiqiao Yuan and Fengli Wang
Int. J. Mol. Sci. 2024, 25(22), 12074; https://doi.org/10.3390/ijms252212074 - 10 Nov 2024
Viewed by 592
Abstract
Spermatogenesis is a highly coordinated process that requires the precise expression of specific subsets of genes in different types of germ cells, controlled both temporally and spatially. Among these genes, those that can exert an indispensable influence in spermatogenesis via participating in alternative [...] Read more.
Spermatogenesis is a highly coordinated process that requires the precise expression of specific subsets of genes in different types of germ cells, controlled both temporally and spatially. Among these genes, those that can exert an indispensable influence in spermatogenesis via participating in alternative splicing make up the overwhelming majority. mRNA alternative-splicing (AS) events can generate various isoforms with distinct functions from a single DNA sequence, based on specific AS codes. In addition to enhancing the finite diversity of the genome, AS can also regulate the transcription and translation of certain genes by directly binding to their cis-elements or by recruiting trans-elements that interact with consensus motifs. The testis, being one of the most complex tissue transcriptomes, undergoes unparalleled transcriptional and translational activity, supporting the dramatic and dynamic transitions that occur during spermatogenesis. Consequently, AS plays a vital role in producing an extensive array of transcripts and coordinating significant changes throughout this process. In this review, we summarize the intricate functional network of alternative splicing in spermatogenesis based on the integration of current research findings. Full article
(This article belongs to the Special Issue Molecular Insights into Reproductive Biology and Related Diseases)
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